Q727C6 · RPOC_NITV2

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site75Zn2+ 1 (UniProtKB | ChEBI)
Binding site77Zn2+ 1 (UniProtKB | ChEBI)
Binding site90Zn2+ 1 (UniProtKB | ChEBI)
Binding site93Zn2+ 1 (UniProtKB | ChEBI)
Binding site466Mg2+ (UniProtKB | ChEBI)
Binding site468Mg2+ (UniProtKB | ChEBI)
Binding site470Mg2+ (UniProtKB | ChEBI)
Binding site809Zn2+ 2 (UniProtKB | ChEBI)
Binding site883Zn2+ 2 (UniProtKB | ChEBI)
Binding site890Zn2+ 2 (UniProtKB | ChEBI)
Binding site893Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentDNA-directed RNA polymerase complex
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular Functionmagnesium ion binding
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed RNA polymerase subunit beta'
  • EC number
  • Short names
    RNAP subunit beta'
  • Alternative names
    • RNA polymerase subunit beta'
    • Transcriptase subunit beta'

Gene names

    • Name
      rpoC
    • Ordered locus names
      DVU_2929

Organism names

Accessions

  • Primary accession
    Q727C6

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002255321-1385DNA-directed RNA polymerase subunit beta'

Proteomic databases

Interaction

Subunit

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q727C6rpoB Q727C74EBI-10065699, EBI-10066295

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the RNA polymerase beta' chain family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,385
  • Mass (Da)
    154,813
  • Last updated
    2004-07-05 v1
  • Checksum
    1B7C3027F1EF7907
MTLDDLFTVRGSAANIANIRNLKAIQITIASPENIREWSYGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECNCGKYKRMKHRGIVCEKCGVEVIASKVRRERMGHIELAAPVAHIWFLKTLPSKIGTLLDMTMADLEKVLYFDSYIVLDPGSTNLTKMQVISEDQYLQVIDHYGEDALTVGMGAEAVRSLLEELNLEELRVQLREESQATKSQTKKKKLTKRLKIVEAFLESNNKPEWMVMEVIPVIPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLMELGAPDIIIRNEKRMLQEAVDALFDNGRRGRAITGTNGRPLKSLSDMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKLHQCGLPKKMALELFKPFIYSELEKRGLASTIKSAKKMVEREELVVWDILEEVVREYPIMLNRAPTLHRLGIQSFEPLLVEGKAIQLHPLVCSAYNADFDGDQMAVHVPLSVEAQIECRVLMMSTNNILSPANGSPVIVPSQDIVLGLYYMTVDRSFEKGENMSFCAPWEVVAAYDAGVVALHARINVRMEDGKVVRTTVGRILVWELLPHCVPFSMVNTTLTKKNIARLVSTAYRDAGTKATVILCDRLKDVGYEYATRAGVTIAVKDLTIPSTKKGLIETAQNEVDDIERQYRDGIITRTEKYNKVVDVWTKATQDVSNEMIREISSDIVEDPRTGAKEANSSFNSIYMMSTSGARGNQDQMRQLAGMRGLMAKPSGEIIETPITSSFREGLSVLQYFTSTHGARKGLADTALKTANSGYLTRRLVDVVQDVIVSEHDCGTVDGIELTHIKEGGEIKIPLADRALGRVLLYPVYDPETRDLLFPENTLVDENVAKVLVEREVSSVMIRSALTCQSDRGICTLCYGRDLARGHIVNIGETVGIIAAQSIGEPGTQLTMRTFHIGGTASREIERSSFEAQHPGRVILSRVKAVRNRDGQYMVMGKSGQLAIVDDQGREREKYTLPNGSRLLVTEGEEIRKGQILAEWDPFNEPFVSEVDGVIRFSDIVEGKTFQEKMDEATRMTTQTIIEYRTTNFRPSISICDEHGEVKMRGNNIPATYSLPVGAIIMVKNGQDLQAGDIIARKPRETSKTKDIVGGLPRVAELFEVRKPKDMAVVSEIAGIVTYAGETKGKRKLVVTPEIGEAKEYLVPKGKHITVTDGDFVEAGDLLTEGHPELHDILRTRGEKYLARYLTDEIQEVYRFQGVAIDDKHIEVIVRQMLKKVTVLDPGGTTFLVGEQVDKGEFRVENTRAMGEGRTPATAEPLVLGITQASLTTSSFISAASFQETTKVLTEASLRGKMDYLRGLKENVIVGRLIPAGTGYREYVNTDILVPEQRERPDKFLEDLEENPLLVDIY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017285
EMBL· GenBank· DDBJ
AAS97401.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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