Q71VM4 · IMA1A_ORYSJ
- ProteinImportin subunit alpha-1a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids526 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Functions in nuclear protein import. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | perinuclear region of cytoplasm | |
Molecular Function | nuclear import signal receptor activity | |
Molecular Function | nuclear localization sequence binding | |
Biological Process | NLS-bearing protein import into nucleus |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameImportin subunit alpha-1a
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ71VM4
- Secondary accessions
Proteomes
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000120740 | 1-526 | UniProt | Importin subunit alpha-1a | |||
Sequence: MSLRPSERVEVRRNRYKVAVDAEEGRRRREDNMVEIRKSRREESLLKKRREGLQAQAPVPASAATGVDKKLESLPAMIGGVYSDDNNLQLEATTQFRKLLSIERSPPIEEVIQSGVVPRFVQFLTREDFPQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCRDLVLANGALLPLLAQLNEHTKLSMLRNATWTLSNFCRGKPQPSFEQTRPALPALARLIHSNDEEVLTDACWALSYLSDGTNDKIQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVTGDDAQTQCIIDHQALPCLLSLLTQNLKKSIKKEACWTISNITAGNKDQIQAVINAGIIGPLVNLLQTAEFDIKKEAAWAISNATSGGSHDQIKYLVSEGCIKPLCDLLICPDIRIVTVCLEGLENILKVGETDKTLAAGDVNVFSQMIDEAEGLEKIENLQSHDNNEIYEKAVKILEAYWMDEEDDTMGATTVAAPQGATFDFGQGGGAAQFK | |||||||
Modified residue (large scale data) | 105 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 189 | PTMeXchange | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Tissue specificity
Highly expressed in callus, followed by root and etiolated leaf. Low expression in green leaf.
Induction
In both etiolated and green leaves, down-regulated by light. In green leaf, increased by dark treatment.
Gene expression databases
Interaction
Subunit
Forms a complex with importin subunit beta-1. The whole complex, most stable and composed of importin alpha, importin beta and NLS substrate, is referred to as PTAC or pore targeting complex. Interacts with mungbean yellow mosaic virus capsid protein.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-58 | IBB | ||||
Sequence: MSLRPSERVEVRRNRYKVAVDAEEGRRRREDNMVEIRKSRREESLLKKRREGLQAQAP | ||||||
Repeat | 105-145 | ARM 1 | ||||
Sequence: SPPIEEVIQSGVVPRFVQFLTREDFPQLQFEAAWALTNIAS | ||||||
Repeat | 148-187 | ARM 2 | ||||
Sequence: SENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAG | ||||||
Repeat | 190-230 | ARM 3 | ||||
Sequence: PKCRDLVLANGALLPLLAQLNEHTKLSMLRNATWTLSNFCR | ||||||
Repeat | 232-271 | ARM 4 | ||||
Sequence: KPQPSFEQTRPALPALARLIHSNDEEVLTDACWALSYLSD | ||||||
Repeat | 274-313 | ARM 5 | ||||
Sequence: NDKIQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVT | ||||||
Repeat | 316-356 | ARM 6 | ||||
Sequence: DAQTQCIIDHQALPCLLSLLTQNLKKSIKKEACWTISNITA | ||||||
Repeat | 359-398 | ARM 7 | ||||
Sequence: KDQIQAVINAGIIGPLVNLLQTAEFDIKKEAAWAISNATS | ||||||
Repeat | 402-441 | ARM 8 | ||||
Sequence: HDQIKYLVSEGCIKPLCDLLICPDIRIVTVCLEGLENILK |
Sequence similarities
Belongs to the importin alpha family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length526
- Mass (Da)57,571
- Last updated2005-04-26 v2
- Checksum7A7DA264968FC983
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 473-474 | in Ref. 2; AAQ13406 | ||||
Sequence: LQ → FE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB004660 EMBL· GenBank· DDBJ | BAA31165.1 EMBL· GenBank· DDBJ | mRNA | ||
AF005265 EMBL· GenBank· DDBJ | AAQ13406.1 EMBL· GenBank· DDBJ | mRNA | ||
AB004814 EMBL· GenBank· DDBJ | BAA31166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP000816 EMBL· GenBank· DDBJ | BAA87855.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014957 EMBL· GenBank· DDBJ | BAS71366.1 EMBL· GenBank· DDBJ | Genomic DNA |