Q70Z16 · NAP1D_TOBAC
- ProteinNucleosome assembly protein 1;4
- GeneNAP1;4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids356 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May modulate chromatin structure by regulation of nucleosome assembly/disassembly (By similarity).
Could function together with B-type cyclins in the regulation of microtubule dynamics
Could function together with B-type cyclins in the regulation of microtubule dynamics
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Molecular Function | histone binding | |
Biological Process | double-strand break repair via homologous recombination | |
Biological Process | nucleosome assembly |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameNucleosome assembly protein 1;4
- Short namesNtNAP1;4
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Solanales > Solanaceae > Nicotianoideae > Nicotianeae > Nicotiana
Accessions
- Primary accessionQ70Z16
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000423701 | 1-356 | Nucleosome assembly protein 1;4 | |||
Sequence: MSNSNKDHFDMSDLGASLPAAAAALSAEDRAGLVNALKNKLQNLAGQHSDILETLTPQVRKRVDVLRELQSQHDELESHFFEERAALEAKYQKLYEPLYTKRYEIVNGVVEVEGVNEAPMNQEEDKEAGNEKGVPNFWLTAMKTNEILAEEISERDEEALKYLKDIKWCKIDDRKGFKLEFFFDTNPFFTNSVLTKTYHMIDDDDPILEKAIGTKIDWCPGKCLTQKILKKKPKKGSKNAKPIIKTETCESFFNFFKPPQVPEDDDDDDIDEDAAEELQNLMEQDYDIGSTIRDKIIPHAVSWFTGEAAEGDEFEDIEDDDDDDDDDDDEDDEDEEDEDDEEEEKSKKKSSALKVE |
Proteomic databases
Expression
Developmental stage
Highly expressed at the G1/S transition.
Interaction
Subunit
Can form homomeric and heteromeric protein complexes with NAP1;3. Binds histones H2A and H2B in vivo. Also able to bind histones H1 and H4 in vitro. Interacts with CYCB1;1 and with alpha tubulin.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, motif, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 34-88 | |||||
Sequence: VNALKNKLQNLAGQHSDILETLTPQVRKRVDVLRELQSQHDELESHFFEERAALE | ||||||
Motif | 55-70 | Nuclear export signal | ||||
Sequence: LTPQVRKRVDVLRELQ | ||||||
Motif | 230-235 | Nuclear localization signal | ||||
Sequence: KKKPKK | ||||||
Region | 304-356 | Disordered | ||||
Sequence: FTGEAAEGDEFEDIEDDDDDDDDDDDEDDEDEEDEDDEEEEKSKKKSSALKVE | ||||||
Compositional bias | 309-342 | Acidic residues | ||||
Sequence: AEGDEFEDIEDDDDDDDDDDDEDDEDEEDEDDEE |
Domain
The acidic domain is probably involved in the interaction with histones.
Sequence similarities
Belongs to the nucleosome assembly protein (NAP) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length356
- Mass (Da)40,727
- Last updated2004-07-05 v1
- Checksum26AFA3CA6F2D6016
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 309-342 | Acidic residues | ||||
Sequence: AEGDEFEDIEDDDDDDDDDDDEDDEDEEDEDDEE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ438616 EMBL· GenBank· DDBJ | CAD27463.1 EMBL· GenBank· DDBJ | mRNA |