Q70KF0 · DOIAD_MICEC

Function

function

Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD+ or NADP+, forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 2-deoxystreptamine biosynthesis; 2-deoxystreptamine from D-glucose 6-phosphate: step 3/4.
Antibiotic biosynthesis; gentamicin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site41Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site63Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site92Zn2+ 2 (UniProtKB | ChEBI)
Binding site95Zn2+ 2 (UniProtKB | ChEBI)
Binding site98Zn2+ 2 (UniProtKB | ChEBI)
Binding site106Zn2+ 2 (UniProtKB | ChEBI)
Binding site147Zn2+ 1 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-deoxy-scyllo-inosamine dehydrogenase
  • EC number
  • Short names
    DOIA dehydrogenase

Gene names

    • Name
      gacH
    • Synonyms
      genE, gntP

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 15835 / DSM 43036 / BCRC 11561 / JCM 3074 / NBRC 12575 / NCIMB 12882 / NRRL 2953
  • Taxonomic lineage
    Bacteria > Bacillati > Actinomycetota > Actinomycetes > Micromonosporales > Micromonosporaceae > Micromonospora

Accessions

  • Primary accession
    Q70KF0

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002340421-3402-deoxy-scyllo-inosamine dehydrogenase

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    340
  • Mass (Da)
    36,023
  • Last updated
    2004-07-05 v1
  • MD5 Checksum
    B35E290D2F54391B1928D3E19887EB9F
MGGRMRALQFHGGHKAQIIDTPRPEAPPGWAVVKVHYCCLCGSDLWLYRGKWHGNRYPIVPGHEWAGVVDSAPEGYESWVGRPVTGDLIVGCQGCGPCRDGLPVMCENLIEIGFTVDGGCAGYVAVPITNLYLLPEGMDLAAASQTEPLAVALHAVDRINLRPAERVAVLGAGGIGQLILQSARATGATVTLATDLVAERRKIAEESGAAAAVHPSELPELTSYADKVDVVFEASGDPESVVRALDLVRPGGRVCLVGYQVGAEHALETARLPLSYASLVGVMGPGGKYREAVDLLANGAIDTQPILTDIVTLDDYAPAIDRAINRTDGTVRVVFDLRNE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY524043
EMBL· GenBank· DDBJ
AAR98562.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ575934
EMBL· GenBank· DDBJ
CAF34032.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ628149
EMBL· GenBank· DDBJ
CAF31445.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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