Q70KF0 · DOIAD_MICEC
- Protein2-deoxy-scyllo-inosamine dehydrogenase
- GenegacH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids340 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD+ or NADP+, forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI).
Catalytic activity
- 2-deoxy-scyllo-inosamine + NADP+ = 3-amino-2,3-dideoxy-scyllo-inosose + NADPH + H+
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Pathway
Metabolic intermediate biosynthesis; 2-deoxystreptamine biosynthesis; 2-deoxystreptamine from D-glucose 6-phosphate: step 3/4.
Antibiotic biosynthesis; gentamicin biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 41 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 63 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 92 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 95 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 98 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 106 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 147 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-deoxy-scyllo-inosamine dehydrogenase
- EC number
- Short namesDOIA dehydrogenase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillati > Actinomycetota > Actinomycetes > Micromonosporales > Micromonosporaceae > Micromonospora
Accessions
- Primary accessionQ70KF0
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000234042 | 1-340 | 2-deoxy-scyllo-inosamine dehydrogenase | ||
Structure
Family & Domains
Sequence similarities
Belongs to the zinc-containing alcohol dehydrogenase family. DOIA dehydrogenase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length340
- Mass (Da)36,023
- Last updated2004-07-05 v1
- MD5 ChecksumB35E290D2F54391B1928D3E19887EB9F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY524043 EMBL· GenBank· DDBJ | AAR98562.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ575934 EMBL· GenBank· DDBJ | CAF34032.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ628149 EMBL· GenBank· DDBJ | CAF31445.1 EMBL· GenBank· DDBJ | Genomic DNA |