Nesprin-1alpha recruits Akap450 to the nuclear envelope (NE)independently of kinesin and that Akap450 but not other centrosomal proteins is required for microtubule nucleation from the NE.
AKAP9 and by inference the regulation of the microtubule network are critical for blood-testis barrier function and subsequent germ cell development during spermatogenesis
We postulate that this novel interaction linking MVI with the PKA pathway could be important for targeting AKAP9-PKA complex within cells and/or providing PKA to phosphorylate MVI tail domain.
Overexpression of an AKAP450 fragment containing the CK1delta-binding site inhibits Golgi-derived microtubule nucleation Golgi distribution of intraflagellar transport protein 20 homologue and ciliogenesis.
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