During the monocytic differentiation of HL60 cells miR-16 expression showed a time-dependent increase but myeloblastosis oncogene (MYB) expression gradually decreased.
Results demonstrated that MYB is aberrantly overexpressed in salivary adenoid cystic carcinoma (SACC) tissues and promotes SACC cell proliferation and metastasis.
Collectively our data showed that ZFAS1 contributed to the development of AML by sequestering miR-150 from Myb or Sp1 elucidating the central roles of ZFAS1/miR-150/Myb and ZFAS1/miR-150/Sp1 pathways in the tumorigenesis of AML and deepening our understanding on the etiology of leukemia.
These results indicated that low expression of Mda-7/IL-24 along with high expression of C-myb are predictors for poor prognosis of Burkitt lymphoma patients; this outcome suggests that Mda-7/IL-24 and C-myb might be potential targets for clinical treatment of Burkitt lymphoma.
In the present study MYB or MYBL1 locus rearrangement was detected in nearly all adenoid cystic carcinoma cases and therefore it would be a good diagnostic marker for adenoid cystic carcinoma.
Salivary gland ACC cases expressing the MYB-NFIB chimeric gene showed significantly higher blood vessels density compared to non-expressing cases and suggested that higher VEGF production capability in the former cases may be the cause. The findings also suggested that MYB-NFIB chimeric gene expression may be related to the onset age of ACC.
The coexpression of GATA3 and MYB might be helpful in the distinction of primary cutaneous adnexal carcinoma versus metastatic breast salivary gland or urothelial carcinoma
A genome-wide association study (GWAS) identified loci associated with the plasma triglyceride (TG) response to omega-3 fatty acid (FA) supplementation in IQCJ NXPH1 PHF17 and MYB.
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