Uncoupling the Folding and Binding of an Intrinsically Disordered Protein.
- AnnotationData observe that increasing and decreasing the helical stability of c-Myb over a broad range has a small effect on the binding affinity to KIX domain of CREB binding protein. To reduce the binding affinity by more than 1 kcal/mol it was necessary to introduce glycine or proline in the middle of the c-Myb helix.
- CategoriesFamily & Domains, Disease & Variants, Structure
- SourceGeneRif: 4602