Q6ZQ06 · CE162_MOUSE
- ProteinCentrosomal protein of 162 kDa
- GeneCep162
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1403 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axonemal microtubule | |
Cellular Component | centriolar satellite | |
Cellular Component | centriole | |
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Cellular Component | spindle | |
Biological Process | cilium assembly |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCentrosomal protein of 162 kDa
- Short namesCep162
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ6ZQ06
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to spindle microtubules during mitosis (By similarity).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000295629 | 1-1403 | Centrosomal protein of 162 kDa | ||
Modified residue | 160 | Phosphoserine | |||
Modified residue | 163 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 20-46 | Disordered | |||
Region | 169-243 | Disordered | |||
Compositional bias | 182-210 | Acidic residues | |||
Compositional bias | 211-235 | Basic and acidic residues | |||
Region | 256-292 | Disordered | |||
Region | 306-348 | Disordered | |||
Compositional bias | 453-472 | Polar residues | |||
Region | 453-606 | Disordered | |||
Compositional bias | 504-528 | Polar residues | |||
Compositional bias | 537-553 | Polar residues | |||
Coiled coil | 614-1124 | ||||
Compositional bias | 1126-1146 | Basic and acidic residues | |||
Region | 1126-1147 | Disordered | |||
Coiled coil | 1174-1386 | ||||
Sequence similarities
Belongs to the CEP162 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,403
- Mass (Da)160,855
- Last updated2007-07-24 v2
- ChecksumAA1363D5407D7FFF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 182-210 | Acidic residues | |||
Compositional bias | 211-235 | Basic and acidic residues | |||
Compositional bias | 453-472 | Polar residues | |||
Compositional bias | 504-528 | Polar residues | |||
Compositional bias | 537-553 | Polar residues | |||
Compositional bias | 1126-1146 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC125370 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC150998 EMBL· GenBank· DDBJ | AAI50999.1 EMBL· GenBank· DDBJ | mRNA | ||
BC151006 EMBL· GenBank· DDBJ | AAI51007.1 EMBL· GenBank· DDBJ | mRNA | ||
AK129260 EMBL· GenBank· DDBJ | BAC98070.1 EMBL· GenBank· DDBJ | mRNA |