Q6ZQ06 · CE162_MOUSE

  • Protein
    Centrosomal protein of 162 kDa
  • Gene
    Cep162
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxonemal microtubule
Cellular Componentcentriolar satellite
Cellular Componentcentriole
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentspindle
Biological Processcilium assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Centrosomal protein of 162 kDa
  • Short names
    Cep162
  • Alternative names
    • Protein QN1 homolog

Gene names

    • Name
      Cep162
    • Synonyms
      Kiaa1009, Qn1

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • OF1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6ZQ06
  • Secondary accessions
    • B9EKN3
    • Q6P262

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Note: Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to spindle microtubules during mitosis (By similarity).

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00002956291-1403Centrosomal protein of 162 kDa
Modified residue160Phosphoserine
Modified residue163Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with CPNE4 (PubMed:12522145).
Interacts with alpha-tubulin. Interacts with CEP290 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, coiled coil.

Type
IDPosition(s)Description
Region20-46Disordered
Region169-243Disordered
Compositional bias182-210Acidic residues
Compositional bias211-235Basic and acidic residues
Region256-292Disordered
Region306-348Disordered
Compositional bias453-472Polar residues
Region453-606Disordered
Compositional bias504-528Polar residues
Compositional bias537-553Polar residues
Coiled coil614-1124
Compositional bias1126-1146Basic and acidic residues
Region1126-1147Disordered
Coiled coil1174-1386

Sequence similarities

Belongs to the CEP162 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,403
  • Mass (Da)
    160,855
  • Last updated
    2007-07-24 v2
  • Checksum
    AA1363D5407D7FFF
MAHYFKVDLDEEFERFMKELSDDSFENSNKTPRQPNEDNKEMKKKDPVPWWIAEDDFEDDGLLGTNVSYLKTKKTYQPVMDTEEESAEKVQFLKSSGTSILSVDSLEANELVVSEPHHSTLGLGLDTLEEQEEKEQFFARLEKGLTSSIDYSKLNQELDSDDSAQLKALHRYPRNTEPAEDGCENESEQEELPETYSDDFEDAEDADDPLITKDEETHPKENSESGKDSFPKQEEEKTGMLANVVLLDSFDSVEDVGLSSQEKATPKAKAPPEITDDGPAETGVPYGQSSGDTEALHQAYCHVAHSLGDTGEPRIEASTVQTVRSSIKDGLQENEESSKNVSTTESDLPTVEELMQPIRIDSYGIRAFDLQPISLKKATDSKEAESVGSLPLKTNTNTVSQDTRHAIQFPHKHDESVVLHRTADEGMGSSCPATEEHLDKMYLEILKKKTSVNPSLLPQDDKMNQTSRSQLGAGEEVPVIGKQVPCKKARSTPSLPKRKPQSGLYASARSSGYGKPSSPLQLFSALEKKTSKDNTKTKSVRSIPTSNQFRKREILSGTKLIKPAASNKPSPHREGSPATPKRPEDPSDDSFVQLQTEPLGSYGGNREKELLMLKRAQDAEEKWTGAQALMEQMKMTFCEKEKELENTVESLKRQQERELFRLNQENYILQAKLSSFEETSRKQRWLQFGETSDPLTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQNLFSELASLKEQMHKNHFLSQAVENTEPTKNQSFTDLLAELRAAQKEKNHLMEDIKRLKQDKQALEVDLEKVKRERDQAKDQIAYATGEKLYEIKILEETHKQEVSRLQKRLQWYAENQELLDRDAARLREANEETEKLRLEIEKLKTESGSPATQQRLRSKERALDAKRIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDSVDRNTVEFMERRIKKLEADLEGKDEEAKKSLRTMEQQFQKMKIQYEQRLEEQEQLLAHRQKEAPQSQRNSSSRLKALETELGDIKEAHQITVRKLEAEIDVLKHQNADLEHKKNDKGDQGLQSIEFQVEQAQARAKLARLNEELAAKGREIQDLTKTVERLQKERRMMLSRQIPRSREETAAKRLKKDPNRGHGNAFPETLDGKLYHPHTFTDSHISEVLEENYRLRSELEGLILERSKLKMESEAAVCQLENSMKRVKDDAAAHIASLKASHEREIEKLLCQNAIENSSSKVAELNRKIATQEVLLKHFQGQVNELQGKQESLAVSQVREEILQKQITKLLEELKEAKENHTPEMKHFMGLERKIKQMEMRHRQREQELQQIIQQTRQVVETEQNKEVEKWKRLAQLKNRELDKFRTELDSILDVLRELHRQGVVVPMALAGEENTAEF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias182-210Acidic residues
Compositional bias211-235Basic and acidic residues
Compositional bias453-472Polar residues
Compositional bias504-528Polar residues
Compositional bias537-553Polar residues
Compositional bias1126-1146Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC125370
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC150998
EMBL· GenBank· DDBJ
AAI50999.1
EMBL· GenBank· DDBJ
mRNA
BC151006
EMBL· GenBank· DDBJ
AAI51007.1
EMBL· GenBank· DDBJ
mRNA
AK129260
EMBL· GenBank· DDBJ
BAC98070.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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