Q6ZPV3 · Q6ZPV3_MOUSE
- ProteinArylsulfatase
- GeneSulf2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids948 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- an aryl sulfate + H2O = a phenol + H+ + sulfate
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 125 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 126 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 161 | Nucleophile | ||||
Sequence: C | ||||||
Binding site | 161 | Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine | ||||
Sequence: C | ||||||
Binding site | 390 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 391 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi stack | |
Molecular Function | calcium ion binding | |
Molecular Function | sulfuric ester hydrolase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArylsulfatase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ6ZPV3
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 161 | 3-oxoalanine (Cys) | ||||
Sequence: C |
Post-translational modification
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic residues | ||||
Sequence: VRPGPARVRARRRERG | ||||||
Region | 1-54 | Disordered | ||||
Sequence: VRPGPARVRARRRERGRPPARQAAGREPPGLRAGARGGRGGGDPEGRGEGIPSS | ||||||
Domain | 117-447 | Sulfatase N-terminal | ||||
Sequence: PNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSTDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYDMLVETGELDNTYILYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGSLNPHIVLNIDLAPTILDIAG | ||||||
Domain | 606-742 | Extracellular sulfatase C-terminal | ||||
Sequence: KTSYARNRSIRSVAIEVDGEIYHVGLDTVPQPRNLSKPHWPGAPEDQDDKDGGSFSGTGGLPDYSAPNPIKVTHRCYILENDTVQCDLDLYKSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHK | ||||||
Region | 633-669 | Disordered | ||||
Sequence: TVPQPRNLSKPHWPGAPEDQDDKDGGSFSGTGGLPDY | ||||||
Coiled coil | 706-733 | |||||
Sequence: KLHIDHEIETLQNKIKNLREVRGHLKKK |
Sequence similarities
Belongs to the sulfatase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length948
- Mass (Da)108,157
- Last updated2004-07-05 v1
- Checksum225A03A4D3630255
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V | ||||||
Compositional bias | 1-16 | Basic residues | ||||
Sequence: VRPGPARVRARRRERG |