Q6ZPV3 · Q6ZPV3_MOUSE

  • Protein
    Arylsulfatase
  • Gene
    Sulf2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site125Ca2+ (UniProtKB | ChEBI)
Binding site126Ca2+ (UniProtKB | ChEBI)
Active site161Nucleophile
Binding site161Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine
Binding site390Ca2+ (UniProtKB | ChEBI)
Binding site391Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi stack
Molecular Functioncalcium ion binding
Molecular Functionsulfuric ester hydrolase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Arylsulfatase
  • EC number
  • Alternative names
    • N-acetylglucosamine-6-sulfatase

Gene names

    • Name
      Sulf2
    • Synonyms
      mKIAA1247

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6ZPV3

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue1613-oxoalanine (Cys)

Post-translational modification

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

Keywords

Proteomic databases

Family & Domains

Features

Showing features for compositional bias, region, domain, coiled coil.

TypeIDPosition(s)Description
Compositional bias1-16Basic residues
Region1-54Disordered
Domain117-447Sulfatase N-terminal
Domain606-742Extracellular sulfatase C-terminal
Region633-669Disordered
Coiled coil706-733

Sequence similarities

Belongs to the sulfatase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    948
  • Mass (Da)
    108,157
  • Last updated
    2004-07-05 v1
  • Checksum
    225A03A4D3630255
VRPGPARVRARRRERGRPPARQAAGREPPGLRAGARGGRGGGDPEGRGEGIPSSRHHLGLCIQEEAKDQQATPMAPPGLPLWLLSTALLSLLAGSSAFLSHPRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSTDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYDMLVETGELDNTYILYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGSLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDSERPVNRFHLKKKLRVWRDSFLVERGKLLHKREGDKVNAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDASGTLKLHKCKGPMRFGGGGGGRALSNLVPKYDGQSSEACSCDSGGGGDYKLGLAGRRKLFKKKYKTSYARNRSIRSVAIEVDGEIYHVGLDTVPQPRNLSKPHWPGAPEDQDDKDGGSFSGTGGLPDYSAPNPIKVTHRCYILENDTVQCDLDLYKSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHKISYHSQHKGRLKHKGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNHHWQTAPLWTLGPFCACTSANNNTYWCLRTINETHNFLFCEFATGFIEYFDLSTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLRDGGSYEQYRQFQRRKWPEMKRPSSKSLGQLWEGWEG

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias1-16Basic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK129316
EMBL· GenBank· DDBJ
BAC98126.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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