Q6ZPK0 · PF21A_MOUSE
- ProteinPHD finger protein 21A
- GenePhf21a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids688 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (By similarity).
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 434-446 | A.T hook | ||||
Sequence: TRKRGRPPKYNAV |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | DNA repair complex | |
Cellular Component | histone deacetylase complex | |
Molecular Function | chromatin binding | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Biological Process | chromatin organization | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | suckling behavior |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
May be implicated in the neuronal function. Required for neonatal viability.
Names & Taxonomy
Protein names
- Recommended namePHD finger protein 21A
- Alternative names
Gene names
- Community suggested namesBHC80
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ6ZPK0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, cross-link, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000226768 | 1-688 | PHD finger protein 21A | |||
Sequence: MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLSQSENKLQTAQQQPLQPLQQQQPQQPQQQQQQQQQHAQQSAAAPPSLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHPEAEEKQAESRTVTPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPPSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLEPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKELSSSISKCMEMKSSILARQKEMRSSLDKVKRLIRLVHGVDLCRPVDSEATAGALSNGPDCTPPANAASTPAPSPSSQSCTANCNQGEETK | ||||||
Cross-link | 65 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 453 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 456 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the brain and testis. Weakly or not expressed in other tissues tested. Localized throughout the central nervous system (CNS) in brain, including the cerebellum, hippocampus, and cortex. Notably present in neuronal cells of granular cell layer and dentate gyrus in cerebellum and hippocampus, respectively. In the seminiferous tubules, the signals it is present strongly in spermatocytes, and weakly in spermatogonia and round spermatids. In some cases, it is also observed solely in spermatocytes (at protein level).
Interaction
Subunit
Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, it interacts directly with HDAC1, HDAC2, HMG20B/BRAF35, KDM1A and RCOR1/CoREST (By similarity).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 78-127 | Disordered | ||||
Sequence: SQSENKLQTAQQQPLQPLQQQQPQQPQQQQQQQQQHAQQSAAAPPSLTAS | ||||||
Region | 327-373 | Disordered | ||||
Sequence: PQTVQLSKPSLEKQTVKSHPEAEEKQAESRTVTPPAAPKPKREENPQ | ||||||
Compositional bias | 340-354 | Basic and acidic residues | ||||
Sequence: QTVKSHPEAEEKQAE | ||||||
Region | 449-471 | Disordered | ||||
Sequence: FGALTPTSPPSSHPDSPENEKTE | ||||||
Zinc finger | 497-544 | PHD-type | ||||
Sequence: EDFCSVCRKSGQLLMCDTCSRVYHLDCLEPPLKTIPKGMWICPRCQDQ | ||||||
Coiled coil | 571-609 | |||||
Sequence: KEEEKQKLLKWSSDLKQEREQLEQKVKELSSSISKCMEM | ||||||
Region | 650-688 | Disordered | ||||
Sequence: GALSNGPDCTPPANAASTPAPSPSSQSCTANCNQGEETK | ||||||
Compositional bias | 668-688 | Polar residues | ||||
Sequence: PAPSPSSQSCTANCNQGEETK |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 9 isoforms produced by Alternative splicing.
Q6ZPK0-10
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length688
- Mass (Da)75,597
- Last updated2019-05-08 v3
- Checksum187A2BC69E7E2A5C
Q6ZPK0-2
- Name2
- Differences from canonical
- 129-212: Missing
Q6ZPK0-3
- Name3
- SynonymsBHC80-6(AIF2+5)
Q6ZPK0-4
- Name4
Q6ZPK0-5
- Name5
- SynonymsBHC80-1(AIF1+3)
Q6ZPK0-6
- Name6
- SynonymsBHC80-4(AIF2+3)
Q6ZPK0-7
- Name7
- SynonymsBHC80-2(AIF1+4)
Q6ZPK0-8
- Name8
- SynonymsBHC80-5(AIF2+4)
Q6ZPK0-9
- Name9
- SynonymsBHC80-3(AIF1+5)
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A2AHG3 | A2AHG3_MOUSE | Phf21a | 556 | ||
A2AHG4 | A2AHG4_MOUSE | Phf21a | 641 | ||
F6URE6 | F6URE6_MOUSE | Phf21a | 575 | ||
D3Z764 | D3Z764_MOUSE | Phf21a | 604 | ||
A0A498WGG5 | A0A498WGG5_MOUSE | Phf21a | 688 | ||
F6U6L3 | F6U6L3_MOUSE | Phf21a | 185 | ||
A0A1C7ZN07 | A0A1C7ZN07_MOUSE | Phf21a | 9 | ||
A0A1C7ZN08 | A0A1C7ZN08_MOUSE | Phf21a | 10 | ||
E0CZ79 | E0CZ79_MOUSE | Phf21a | 27 | ||
E0CZ36 | E0CZ36_MOUSE | Phf21a | 14 | ||
E0CYN5 | E0CYN5_MOUSE | Phf21a | 71 | ||
F6TL54 | F6TL54_MOUSE | Phf21a | 189 | ||
F6TKP4 | F6TKP4_MOUSE | Phf21a | 231 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_060158 | 129 | in isoform 3, isoform 6 and isoform 8 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_060157 | 129-212 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_060156 | 129-213 | in isoform 4, isoform 5, isoform 7 and isoform 9 | |||
Sequence: Missing | ||||||
Sequence conflict | 325 | in Ref. 1; BAC65327 and 3; BAC29735 | ||||
Sequence: A → P | ||||||
Compositional bias | 340-354 | Basic and acidic residues | ||||
Sequence: QTVKSHPEAEEKQAE | ||||||
Sequence conflict | 341 | in Ref. 2; BAC98234 | ||||
Sequence: Missing | ||||||
Alternative sequence | VSP_060159 | 341-381 | in isoform 3, isoform 5, isoform 6, isoform 7, isoform 9 and isoform 8 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_060161 | 438-481 | in isoform 7 and isoform 8 | |||
Sequence: GRPPKYNAVLGFGALTPTSPPSSHPDSPENEKTETTFTFPAPVQ → ANEEHWPK | ||||||
Alternative sequence | VSP_060160 | 438-492 | in isoform 6, isoform 5 and isoform 4 | |||
Sequence: GRPPKYNAVLGFGALTPTSPPSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTD → ANEEHWPK | ||||||
Compositional bias | 668-688 | Polar residues | ||||
Sequence: PAPSPSSQSCTANCNQGEETK | ||||||
Sequence conflict | 669 | in Ref. 1; BAC65327 | ||||
Sequence: A → T |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB105178 EMBL· GenBank· DDBJ | BAC65327.1 EMBL· GenBank· DDBJ | mRNA | ||
AK129424 EMBL· GenBank· DDBJ | BAC98234.1 EMBL· GenBank· DDBJ | Transcribed RNA | Frameshift | |
AK037174 EMBL· GenBank· DDBJ | BAC29735.1 EMBL· GenBank· DDBJ | mRNA | ||
AL691462 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL731709 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL732484 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC019181 EMBL· GenBank· DDBJ | AAH19181.1 EMBL· GenBank· DDBJ | mRNA | ||
AY206982 EMBL· GenBank· DDBJ | AAP43962.1 EMBL· GenBank· DDBJ | mRNA |