Q6ZPK0 · PF21A_MOUSE

  • Protein
    PHD finger protein 21A
  • Gene
    Phf21a
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (By similarity).

Features

Showing features for dna binding.

168850100150200250300350400450500550600650
TypeIDPosition(s)Description
DNA binding434-446A.T hook

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentDNA repair complex
Cellular Componenthistone deacetylase complex
Molecular Functionchromatin binding
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Biological Processchromatin organization
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processsuckling behavior

Keywords

Enzyme and pathway databases

Community curation (1)

May be implicated in the neuronal function. Required for neonatal viability.

Names & Taxonomy

Protein names

  • Recommended name
    PHD finger protein 21A
  • Alternative names
    • BHC80a
    • BRAF35-HDAC complex protein BHC80 (mBHC80)

Gene names

    • Name
      Phf21a
    • Synonyms
      Bhc80, Kiaa1696, Pftf1
Community curation (1)

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N-3
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6ZPK0
  • Secondary accessions
    • A2AHG2
    • Q6XVG0
    • Q80Z33
    • Q8CAZ4
    • Q8VEC8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, cross-link, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002267681-688PHD finger protein 21A
Cross-link65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue453Phosphothreonine
Modified residue456Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the brain and testis. Weakly or not expressed in other tissues tested. Localized throughout the central nervous system (CNS) in brain, including the cerebellum, hippocampus, and cortex. Notably present in neuronal cells of granular cell layer and dentate gyrus in cerebellum and hippocampus, respectively. In the seminiferous tubules, the signals it is present strongly in spermatocytes, and weakly in spermatogonia and round spermatids. In some cases, it is also observed solely in spermatocytes (at protein level).

Interaction

Subunit

Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, it interacts directly with HDAC1, HDAC2, HMG20B/BRAF35, KDM1A and RCOR1/CoREST (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, zinc finger, coiled coil.

TypeIDPosition(s)Description
Region78-127Disordered
Region327-373Disordered
Compositional bias340-354Basic and acidic residues
Region449-471Disordered
Zinc finger497-544PHD-type
Coiled coil571-609
Region650-688Disordered
Compositional bias668-688Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (9)
  • Sequence status
    Complete

This entry describes 9 isoforms produced by Alternative splicing.

Q6ZPK0-10

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    688
  • Mass (Da)
    75,597
  • Last updated
    2019-05-08 v3
  • Checksum
    187A2BC69E7E2A5C
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLSQSENKLQTAQQQPLQPLQQQQPQQPQQQQQQQQQHAQQSAAAPPSLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHPEAEEKQAESRTVTPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPPSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLEPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKELSSSISKCMEMKSSILARQKEMRSSLDKVKRLIRLVHGVDLCRPVDSEATAGALSNGPDCTPPANAASTPAPSPSSQSCTANCNQGEETK

Q6ZPK0-2

Q6ZPK0-3

Q6ZPK0-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 129-213: Missing
    • 438-492: GRPPKYNAVLGFGALTPTSPPSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTD → ANEEHWPK

Q6ZPK0-5

  • Name
    5
  • Synonyms
    BHC80-1(AIF1+3)
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q6ZPK0-6

  • Name
    6
  • Synonyms
    BHC80-4(AIF2+3)
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q6ZPK0-7

  • Name
    7
  • Synonyms
    BHC80-2(AIF1+4)
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q6ZPK0-8

  • Name
    8
  • Synonyms
    BHC80-5(AIF2+4)
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q6ZPK0-9

Computationally mapped potential isoform sequences

There are 13 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A2AHG3A2AHG3_MOUSEPhf21a556
A2AHG4A2AHG4_MOUSEPhf21a641
F6URE6F6URE6_MOUSEPhf21a575
D3Z764D3Z764_MOUSEPhf21a604
A0A498WGG5A0A498WGG5_MOUSEPhf21a688
F6U6L3F6U6L3_MOUSEPhf21a185
A0A1C7ZN07A0A1C7ZN07_MOUSEPhf21a9
A0A1C7ZN08A0A1C7ZN08_MOUSEPhf21a10
E0CZ79E0CZ79_MOUSEPhf21a27
E0CZ36E0CZ36_MOUSEPhf21a14
E0CYN5E0CYN5_MOUSEPhf21a71
F6TL54F6TL54_MOUSEPhf21a189
F6TKP4F6TKP4_MOUSEPhf21a231

Sequence caution

The sequence BAC98234.1 differs from that shown. Reason: Frameshift

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_060158129in isoform 3, isoform 6 and isoform 8
Alternative sequenceVSP_060157129-212in isoform 2
Alternative sequenceVSP_060156129-213in isoform 4, isoform 5, isoform 7 and isoform 9
Sequence conflict325in Ref. 1; BAC65327 and 3; BAC29735
Compositional bias340-354Basic and acidic residues
Sequence conflict341in Ref. 2; BAC98234
Alternative sequenceVSP_060159341-381in isoform 3, isoform 5, isoform 6, isoform 7, isoform 9 and isoform 8
Alternative sequenceVSP_060161438-481in isoform 7 and isoform 8
Alternative sequenceVSP_060160438-492in isoform 6, isoform 5 and isoform 4
Compositional bias668-688Polar residues
Sequence conflict669in Ref. 1; BAC65327

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB105178
EMBL· GenBank· DDBJ
BAC65327.1
EMBL· GenBank· DDBJ
mRNA
AK129424
EMBL· GenBank· DDBJ
BAC98234.1
EMBL· GenBank· DDBJ
Transcribed RNA Frameshift
AK037174
EMBL· GenBank· DDBJ
BAC29735.1
EMBL· GenBank· DDBJ
mRNA
AL691462
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL731709
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL732484
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC019181
EMBL· GenBank· DDBJ
AAH19181.1
EMBL· GenBank· DDBJ
mRNA
AY206982
EMBL· GenBank· DDBJ
AAP43962.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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