Q6ZMY6 · WDR88_HUMAN
- ProteinWD repeat-containing protein 88
- GeneWDR88
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids472 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameWD repeat-containing protein 88
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6ZMY6
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_035892 | 166 | in a breast cancer sample; somatic mutation | |||
Sequence: D → H | ||||||
Natural variant | VAR_032030 | 310 | in dbSNP:rs11881580 | |||
Sequence: C → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 537 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000285630 | 1-472 | WD repeat-containing protein 88 | |||
Sequence: MASPPRCSPTAHDRECKLPPPSAPASEYCPGKLSWGTMARALGRFKLSIPHTHLLATLDPLALDREPPPHLLPEKHQVPEKLIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAVGLKLKQCERCDRPFSIFKSDTSSEMFTQCVFCRIDTRGLPADTSSSSSSSERENSPPPRGSKDD |
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q6ZMY6-2 | FOS P01100 | 3 | EBI-25857007, EBI-852851 | |
BINARY | Q6ZMY6-2 | GATM P50440 | 3 | EBI-25857007, EBI-2552594 | |
BINARY | Q6ZMY6-2 | HSF1 Q00613 | 3 | EBI-25857007, EBI-719620 | |
BINARY | Q6ZMY6-2 | TYR P14679-2 | 3 | EBI-25857007, EBI-25894402 | |
BINARY | Q6ZMY6-2 | UQCRC1 P31930 | 3 | EBI-25857007, EBI-1052596 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, repeat, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-22 | Disordered | ||||
Sequence: MASPPRCSPTAHDRECKLPPPS | ||||||
Repeat | 100-139 | WD 1 | ||||
Sequence: GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRD | ||||||
Repeat | 143-182 | WD 2 | ||||
Sequence: RPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWK | ||||||
Repeat | 184-224 | WD 3 | ||||
Sequence: RYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSV | ||||||
Repeat | 228-267 | WD 4 | ||||
Sequence: HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLT | ||||||
Repeat | 271-310 | WD 5 | ||||
Sequence: AHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNC | ||||||
Repeat | 319-358 | WD 6 | ||||
Sequence: GHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLS | ||||||
Repeat | 361-400 | WD 7 | ||||
Sequence: GHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPL | ||||||
Compositional bias | 447-463 | Polar residues | ||||
Sequence: LPADTSSSSSSSERENS | ||||||
Region | 447-472 | Disordered | ||||
Sequence: LPADTSSSSSSSERENSPPPRGSKDD |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q6ZMY6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length472
- Mass (Da)52,621
- Last updated2010-05-18 v2
- ChecksumB525CCC29477F730
Q6ZMY6-2
- Name2
- Differences from canonical
- 415-472: CERCDRPFSIFKSDTSSEMFTQCVFCRIDTRGLPADTSSSSSSSERENSPPPRGSKDD → EKKEAYLKLKQG
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
K7EPH1 | K7EPH1_HUMAN | WDR88 | 164 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_024873 | 415-472 | in isoform 2 | |||
Sequence: CERCDRPFSIFKSDTSSEMFTQCVFCRIDTRGLPADTSSSSSSSERENSPPPRGSKDD → EKKEAYLKLKQG | ||||||
Compositional bias | 447-463 | Polar residues | ||||
Sequence: LPADTSSSSSSSERENS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK131444 EMBL· GenBank· DDBJ | BAD18589.1 EMBL· GenBank· DDBJ | mRNA | ||
AC008738 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC031227 EMBL· GenBank· DDBJ | AAH31227.2 EMBL· GenBank· DDBJ | mRNA | Different initiation |