Q6ZMR3 · LDH6A_HUMAN

  • Protein
    L-lactate dehydrogenase A-like 6A
  • Gene
    LDHAL6A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD+ as a coenzyme (PubMed:18351441).
Significantly increases the transcriptional activity of JUN, when overexpressed

Catalytic activity

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Features

Showing features for binding site, active site.

133250100150200250300
TypeIDPosition(s)Description
Binding site29-57NAD+ (UniProtKB | ChEBI)
Binding site99NAD+ (UniProtKB | ChEBI)
Binding site106substrate
Binding site138NAD+ (UniProtKB | ChEBI)
Binding site138substrate
Binding site169substrate
Active site193Proton acceptor
Binding site248substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular exosome
Cellular Componentmitochondrion
Molecular FunctionL-lactate dehydrogenase activity
Biological Processlactate metabolic process
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-lactate dehydrogenase A-like 6A
  • EC number
  • Short names
    LDHA-like protein 6A

Gene names

    • Name
      LDHAL6A
    • Synonyms
      LDHL2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6ZMR3
  • Secondary accessions
    • D3DQY5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

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The viewer provides 413 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, cross-link, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Initiator methionine1UniProtRemoved
Modified residue2UniProtN-acetylalanine
ChainPRO_00001684572-332UniProtL-lactate dehydrogenase A-like 6A
Modified residue5UniProtN6-acetyllysine; alternate
Modified residue5UniProtN6-succinyllysine; alternate
Modified residue57UniProtN6-acetyllysine; alternate
Cross-link57UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Modified residue81UniProtN6-acetyllysine
Modified residue118UniProtN6-acetyllysine; alternate
Modified residue118UniProtN6-succinyllysine; alternate
Modified residue (large scale data)161PRIDEPhosphoserine
Modified residue (large scale data)167PRIDEPhosphoserine
Modified residue232UniProtN6-acetyllysine
Modified residue239UniProtPhosphotyrosine
Modified residue243UniProtN6-acetyllysine
Modified residue309UniProtPhosphothreonine
Modified residue318UniProtN6-acetyllysine; alternate
Modified residue318UniProtN6-succinyllysine; alternate
Modified residue322UniProtPhosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Testis-specific.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    332
  • Mass (Da)
    36,507
  • Last updated
    2004-07-05 v1
  • Checksum
    7C1B9FCAE9050A9B
MATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDVDEGKLKGETMDLQHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLMIPNITQYSPHCKLLIVTNPVDILTYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQRLGIHSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGYEMVKMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEDIFLSVPCILGENGITDLIKVKLTLEEEACLQKSAETLWEIQKELKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY581313
EMBL· GenBank· DDBJ
AAS93432.1
EMBL· GenBank· DDBJ
mRNA
AK131523
EMBL· GenBank· DDBJ
BAD18662.1
EMBL· GenBank· DDBJ
mRNA
CH471064
EMBL· GenBank· DDBJ
EAW68387.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471064
EMBL· GenBank· DDBJ
EAW68388.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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