Q6Y5M5 · PMIP_PLEDJ
- ProteinMitochondrial intermediate peptidase
- GeneOCT1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids785 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
Catalytic activity
Cofactor
Note: Binds 1 zinc ion.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial matrix | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | peptide metabolic process | |
Biological Process | protein processing involved in protein targeting to mitochondrion |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitochondrial intermediate peptidase
- EC number
- Short namesMIP
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Pleurotineae > Pleurotaceae > Pleurotus
Accessions
- Primary accessionQ6Y5M5
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-43 | Mitochondrion | ||||
Sequence: MLTRPAQNALLKSMQPLFRFRGCLLAKSTSTPRRDISTSSRKL | ||||||
Chain | PRO_0000343203 | 44-785 | Mitochondrial intermediate peptidase | |||
Sequence: AHPTTVPIPPSVDDHALVALLDQPSSFGIVSRLFQTQGGLFGHKELQQPSGFITLAEATLVRAQILTNRILRARESQDELRKVVKNLDRLSDMLCGVIDLAELVRNAHPDRAWVEAANQAYETLCEFMNVLNTDVGLYDVLKAVLSDPTIVQGMGPEEYSTAQIFWHDFEKSAINLPPEQRQRFVSLSSEILVLGREFLQEANTARPPASIHASELAGLKDKGMGARLQLQAQFTQKDLLVYPGSLQAQMIMRCAPAEEPRRKLYIAANSSTPSQIELLERLLRTRAELARLVGKESFAHMTLSDKMAKSPENVQYFLDALMDYTRPYARKALRTLSMRKQAHLQTPPFPTIQPWDRDFYCPPEPPAPPIPLPPLTLGTVFAGLSRLFYHLYGISLRPAECAPGEVWHPHVHKLEVVDEDAGVIGWIYADLFARRGKPSGAAHYTVRCSRRTDDDDEAEDGSIPAAEPYVRVSQSFESSKRHRVRGQDGEFQLPLVVLVCEFARPSVSSGPTVLDWHEVMTLFHEMGHAMHSMIGRTEYQNVSGTRCATDFVELPSILMEHFLSSPTVLSLFDVSSSTPSSAWQVGNHHQDPCHSIDTHSQILLAAMDQIYHSPSVVDPSFSSTSALEALHKSRGLIPYVPGTSFQTQFGHLFGYGATYYSYLFDRAIASRVWSQVFHANPLNRELGDKYKREVLKFGGGRDPWKMISHLLDSPWLENGNADAMKEVGQWRIEDEVGQPGRH |
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length785
- Mass (Da)87,896
- Last updated2004-07-05 v1
- Checksum04FE374000BCB84C