Q6XJG8 · PSD2B_ARATH
- Protein26S proteasome non-ATPase regulatory subunit 2 homolog B
- GeneRPN1B
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids891 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | proteasome complex | |
Cellular Component | proteasome regulatory particle, base subcomplex | |
Molecular Function | enzyme regulator activity | |
Biological Process | protein catabolic process | |
Biological Process | regulation of protein catabolic process |
Names & Taxonomy
Protein names
- Recommended name26S proteasome non-ATPase regulatory subunit 2 homolog B
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ6XJG8
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Normal phenotype.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 45 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000399922 | 1-891 | 26S proteasome non-ATPase regulatory subunit 2 homolog B | |||
Sequence: MAPVPDPNSVGGGAKRDEATTKIPSKDSKKKDDKKEEDLSEEDLQLKQNLELYVERVQDPNPELQKIALESMRKEIRDSTSSMTSVPKPLKFLRPHYGVLKEFHAKMAESDLKKMLADILSVLALTMSAEGERESLNYRLNGSESDIGSWGHEYVRNLAGEIAKEYTIRQGEESSIEDLMDLVQQIVSFHMKHNAETEAVDLLMDVEDLDLLLEHVDNTNFRRTCNYLTSAAKYLPGPDDMLVLDIAYMIYIKFAEYPNALQIALFLDNMQYVKQVFTSCTDLVKKKQFCYMIARHGMTFELDQEMVANDEDKEALQDIVNNSKLSEGYLTLARDIEVMEAKTPEDIYKAHLLDGRASSGPSVDSARQNLSATFVNAFVNAGFGQDKLMTVPSDSTSGSAGNWLFKNKEHGKTSAVASLGMIQLWDVETGLGHLDKYFHSNDNPVVAGALLGVGIVNCGIKNDCDPAFALLSGYIDNEDSSVRIGAIMGLGIAYAGSQNDQIKIRLSPILNDANAPLDVIAFAALSLGMIYVGSCNEEVAQSIIFALMDRSEAELGEALTRFLPLGLGLLYLGKQESVEATAEVSKTFNEKIRKYCDMTLLSCAYAGTGNVLKVQDLLAQCGEHLVKGDIHQGPAVIGLAMVAMSEELGLDMEIRSLERVLQYGEQNIRRAVPLALGLLCISNPKVTVMDTLSRLSHDTDSEVAMAAIISLGLIGAGTNNARIAGMLRNLSSYYYKDASLLFCVRIAQGFVHMGKGLLTLNPFHSERLLLSPTALAGIVTLLHACLDMKSIILGKYHYVLYFLVLAMQPRMMLTVDQSLKPISVPVRVGQAVDVVGQAGRPKTITGFQTHSTPVLLAAGERAELATEKYIPLSPILEGFVILKENPDYREE |
Post-translational modification
Ubiquitinated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in stems, leaves, buds, flowers, siliques and developing seeds.
Developmental stage
Detected in the entire flower with strong signals in carpels, especially in differentiating ovules and the carpel wall. Patchy localization with strong levels in particular cells. In anthers, present at a high level in tetrads of microspores and the tapetum. After fertilization, mostly observed in the embryo up to the heart stage and in the chalazal endospem. Expressed at high levels in silique wall at all stages of carpel development.
Gene expression databases
Interaction
Subunit
Component of the 19S regulatory particle (RP/PA700) base subcomplex of the 26S proteasome. The 26S proteasome is composed of a core protease (CP), known as the 20S proteasome, capped at one or both ends by the 19S regulatory particle (RP/PA700). The RP/PA700 complex is composed of at least 17 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-43 | Disordered | ||||
Sequence: MAPVPDPNSVGGGAKRDEATTKIPSKDSKKKDDKKEEDLSEED | ||||||
Compositional bias | 19-43 | Basic and acidic residues | ||||
Sequence: ATTKIPSKDSKKKDDKKEEDLSEED | ||||||
Repeat | 414-447 | PC 1 | ||||
Sequence: SAVASLGMIQLWDVETGLGHLDKYFHSNDNPVVA | ||||||
Repeat | 448-484 | PC 2 | ||||
Sequence: GALLGVGIVNCGIKNDCDPAFALLSGYIDNEDSSVRI | ||||||
Repeat | 485-519 | PC 3 | ||||
Sequence: GAIMGLGIAYAGSQNDQIKIRLSPILNDANAPLDV | ||||||
Repeat | 522-556 | PC 4 | ||||
Sequence: FAALSLGMIYVGSCNEEVAQSIIFALMDRSEAELG | ||||||
Repeat | 565-594 | PC 5 | ||||
Sequence: LGLGLLYLGKQESVEATAEVSKTFNEKIRK | ||||||
Repeat | 674-705 | PC 6 | ||||
Sequence: LALGLLCISNPKVTVMDTLSRLSHDTDSEVAM | ||||||
Repeat | 724-739 | PC 7 | ||||
Sequence: AGMLRNLSSYYYKDAS |
Sequence similarities
Belongs to the proteasome subunit S2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length891
- Mass (Da)97,954
- Last updated2004-07-05 v1
- Checksum8330D4146ED9F371
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 19-43 | Basic and acidic residues | ||||
Sequence: ATTKIPSKDSKKKDDKKEEDLSEED |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY230829 EMBL· GenBank· DDBJ | AAP86656.1 EMBL· GenBank· DDBJ | mRNA | ||
AL021749 EMBL· GenBank· DDBJ | CAA16886.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161572 EMBL· GenBank· DDBJ | CAB79649.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002687 EMBL· GenBank· DDBJ | AEE85490.1 EMBL· GenBank· DDBJ | Genomic DNA |