a model in which NELF recruits Pcf11 and NCoR1-GPS2-HDAC3 to paused RNAP II reinforcing repression of HIV transcription and establishing a critical checkpoint for HIV transcription and latency.
NELF is associated with normosmic idiopathic hypogonadotropic hypogonadism and Kallmann syndrome either singly or in combination with a mutation in another gene.
12% of Kallman syndrome males have KAL1 deletions but intragenic deletions of the FGFR1 GNRH1 GNRHR GPR54 and NELF genes are uncommon in Idiopathic hypogonadotropic hypogonadism/Kallman syndrome.
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