Biochemical studies suggest the functional interactions of this protein with cell cycle regulators. Cdc25A Cdc25B and Cdc25C can be phosphoryalted by this protein.
Combined Aurora Kinase A and CHK1 Inhibition Enhances Radiosensitivity of Triple-Negative Breast Cancer Through Induction of Apoptosis and Mitotic Catastrophe Associated With Excessive DNA Damage.
Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors.
Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation DNA-Binding Activity and Activation of Downstream Targets in Human Multiple Myeloma Cells.
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