Q6W102 · KATG_SINFN

Function

function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.

Features

Showing features for site, active site, binding site.

TypeIDPosition(s)Description
Site92Transition state stabilizer
Active site96Proton acceptor
Binding site258Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Molecular Functioncatalase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processhydrogen peroxide catabolic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Catalase-peroxidase
  • EC number
  • Short names
    CP
  • Alternative names
    • Peroxidase/catalase

Gene names

    • Name
      katG
    • ORF names
      RNGR00441
    • Ordered locus names
      NGR_b06410

Encoded on

  • Plasmid sym pNGR234b

Organism names

Accessions

  • Primary accession
    Q6W102
  • Secondary accessions
    • C3KPU1

Proteomes

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00003548881-718Catalase-peroxidase
Cross-link95↔217Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-243)
Cross-link217↔243Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)

Post-translational modification

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.

Interaction

Subunit

Homodimer or homotetramer.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-24Disordered

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    718
  • Mass (Da)
    79,396
  • Last updated
    2009-07-07 v3
  • Checksum
    7FE0DE1975427F41
MDQKSDNAGKCPVAHTVPKGRSNRDWWPDQLDVQVLHQHSGLSDPMGKAFNYAEEFKKLDLEELKKDLHALMTESQDWWPADFGHYGGLFIRMAWHSAGTYRITDGRGGAGQGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGNRISWADLMILTGNVALESMGFQTFGFAGGRADVWEPQELFWGPEGTWLGDERYSGERQLDEPLAAVQMGLIYVNPEGPNGNPDPVAAAREIRETFARMAMNDEETVALIAGGHTFGKTHGAGDPSFIGPDPEGGAIEDQGLGWKSTFGTGVGKDAITGGPEVTWSQTPTRWSNYFFENLFNYEWELTKSPAGAHQWKAKNADASIPDAFDASKKHVPTMLTTDLSLRFDPIYEKISRRFLENPDQFADAFARAWFKLTHRDMGPKVRYLGPEVPAEDLIWQDVIPAVDHKLVDENDVADLKGKVLASGLSVQELVSTAWASASTFRGSDKRGGANGARIRLAPQKDWEVNQPAQLARVLSVLEGIQKDFNTAHTGGKKISLADLIVLAGAAGVEKAAKAGGHDITVPFTPGRADASEAQTDAASFAALEPRADGFRNYVSRRRRQFMKPEEALVDRAQLLTLTAPELTVLVGGLRVVFTSRPEVLTNDFFVNLLDMGTQWSPMAEKEGVYEGRDRKTHEVKWTGTRVDLIFGSHSQLRALAEVYASSDAKEKFVGDFVAAWTKVMNADRFDLV

Sequence caution

The sequence AAQ87566.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence AAQ87566.1 differs from that shown. Reason: Frameshift
The sequence ACP22099.1 differs from that shown. Reason: Frameshift

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY316747
EMBL· GenBank· DDBJ
AAQ87566.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
CP000874
EMBL· GenBank· DDBJ
ACP22099.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

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