work suggests that AP-2epsilon which is expressed in late phases of differentiation is not needed to initiate the apical-basal differentiation dichotomy but for maintaining the basal VSNs' identity. In AP-2epsilon mutants we observed a large number of cells that entered the basal program can express apical genes our data suggest that differentiated VSNs of mice retain a notable level of plasticity.
We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes as well as in osteoarthritis development through modulation of Mmp13 expression and activity.
Data demonstrate that transcription factor AP-2epsilon is required for olfactory bulb development specifically the establishment of appropriate neuronal lamination.
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