Q6VII9 · Q6VII9_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 6
- GeneND6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids174 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 6
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6VII9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 25-46 | Helical | ||||
Sequence: PIYGGLVLIVSGVVGCVIILNF | ||||||
Transmembrane | 53-75 | Helical | ||||
Sequence: LMVFLIYLGGMMVVFGYTTAMAI | ||||||
Transmembrane | 81-104 | Helical | ||||
Sequence: AWGSGVEVLVSVLVGLAMEVGLVL | ||||||
Transmembrane | 111-128 | Helical | ||||
Sequence: GVVVVVNFNSVGSWMIYE | ||||||
Transmembrane | 148-168 | Helical | ||||
Sequence: YGRWLVVVTGWMLFVGVYIVI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-15 | |||||
Sequence: MMYALFLLSVGLVMG | ||||||
Chain | PRO_5015098526 | 16-174 | NADH-ubiquinone oxidoreductase chain 6 | |||
Sequence: FVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWMLFVGVYIVIEIARGN |
Proteomic databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Family & Domains
Sequence similarities
Belongs to the complex I subunit 6 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length174
- Mass (Da)18,652
- Last updated2004-07-05 v1
- ChecksumC2FCD9F3FAFC6012
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY339527 EMBL· GenBank· DDBJ | AAP90672.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF177429 EMBL· GenBank· DDBJ | ABL73541.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU600338 EMBL· GenBank· DDBJ | ACD43917.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675035 EMBL· GenBank· DDBJ | AEN03497.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ411481 EMBL· GenBank· DDBJ | AFC36211.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702440 EMBL· GenBank· DDBJ | AFF69689.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ703066 EMBL· GenBank· DDBJ | AFF77827.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705051 EMBL· GenBank· DDBJ | AFG03632.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705468 EMBL· GenBank· DDBJ | AFG09053.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705490 EMBL· GenBank· DDBJ | AFG09339.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128048 EMBL· GenBank· DDBJ | AFN09214.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX171113 EMBL· GenBank· DDBJ | AFN87304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX152805 EMBL· GenBank· DDBJ | AFO20649.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX401416 EMBL· GenBank· DDBJ | AFQ93882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX900767 EMBL· GenBank· DDBJ | AGC20996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC763415 EMBL· GenBank· DDBJ | AGR43809.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF161169 EMBL· GenBank· DDBJ | AGW55774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451095 EMBL· GenBank· DDBJ | AGZ67879.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451104 EMBL· GenBank· DDBJ | AGZ67996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451122 EMBL· GenBank· DDBJ | AGZ68230.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451871 EMBL· GenBank· DDBJ | AGZ77967.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ446282 EMBL· GenBank· DDBJ | AHX49731.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ446283 EMBL· GenBank· DDBJ | AHX49744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ446284 EMBL· GenBank· DDBJ | AHX49757.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ446285 EMBL· GenBank· DDBJ | AHX49770.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ185551 EMBL· GenBank· DDBJ | AID09583.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ185926 EMBL· GenBank· DDBJ | AID14458.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM078028 EMBL· GenBank· DDBJ | AIS37993.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM047191 EMBL· GenBank· DDBJ | AIS38366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457383 EMBL· GenBank· DDBJ | APD65019.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457391 EMBL· GenBank· DDBJ | APD65123.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457664 EMBL· GenBank· DDBJ | APD68671.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY496884 EMBL· GenBank· DDBJ | AQX91548.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY496912 EMBL· GenBank· DDBJ | AQX91912.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY824909 EMBL· GenBank· DDBJ | ARK16207.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY824932 EMBL· GenBank· DDBJ | ARK16506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY967269 EMBL· GenBank· DDBJ | ARM35891.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057283 EMBL· GenBank· DDBJ | ASS13592.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057285 EMBL· GenBank· DDBJ | ASS13618.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG637088 EMBL· GenBank· DDBJ | AWD36616.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH120602 EMBL· GenBank· DDBJ | AZJ10439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH080305 EMBL· GenBank· DDBJ | AZQ07786.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH080306 EMBL· GenBank· DDBJ | AZQ07799.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF437163 EMBL· GenBank· DDBJ | QBZ75364.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN516567 EMBL· GenBank· DDBJ | QFZ96850.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN516620 EMBL· GenBank· DDBJ | QFZ97539.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN540485 EMBL· GenBank· DDBJ | QGL53531.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN540495 EMBL· GenBank· DDBJ | QGL53661.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN046489 EMBL· GenBank· DDBJ | QJX66684.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN046513 EMBL· GenBank· DDBJ | QJX66996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687215 EMBL· GenBank· DDBJ | QLH91634.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687253 EMBL· GenBank· DDBJ | QLH92128.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW389251 EMBL· GenBank· DDBJ | QRC36947.1 EMBL· GenBank· DDBJ | Genomic DNA |