Q6VII9 · Q6VII9_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 6
  • Gene
    ND6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 6
  • EC number

Gene names

    • Name
      ND6
    • Synonyms
      MTND6

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • F126
    • Druze
    • Pol-13
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6VII9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane25-46Helical
Transmembrane53-75Helical
Transmembrane81-104Helical
Transmembrane111-128Helical
Transmembrane148-168Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-15
ChainPRO_501509852616-174NADH-ubiquinone oxidoreductase chain 6

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Sequence similarities

Belongs to the complex I subunit 6 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    174
  • Mass (Da)
    18,652
  • Last updated
    2004-07-05 v1
  • Checksum
    C2FCD9F3FAFC6012
MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWMLFVGVYIVIEIARGN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY339527
EMBL· GenBank· DDBJ
AAP90672.1
EMBL· GenBank· DDBJ
Genomic DNA
EF177429
EMBL· GenBank· DDBJ
ABL73541.1
EMBL· GenBank· DDBJ
Genomic DNA
EU600338
EMBL· GenBank· DDBJ
ACD43917.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675035
EMBL· GenBank· DDBJ
AEN03497.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ411481
EMBL· GenBank· DDBJ
AFC36211.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702440
EMBL· GenBank· DDBJ
AFF69689.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703066
EMBL· GenBank· DDBJ
AFF77827.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705051
EMBL· GenBank· DDBJ
AFG03632.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705468
EMBL· GenBank· DDBJ
AFG09053.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705490
EMBL· GenBank· DDBJ
AFG09339.1
EMBL· GenBank· DDBJ
Genomic DNA
JX128048
EMBL· GenBank· DDBJ
AFN09214.1
EMBL· GenBank· DDBJ
Genomic DNA
JX171113
EMBL· GenBank· DDBJ
AFN87304.1
EMBL· GenBank· DDBJ
Genomic DNA
JX152805
EMBL· GenBank· DDBJ
AFO20649.1
EMBL· GenBank· DDBJ
Genomic DNA
JX401416
EMBL· GenBank· DDBJ
AFQ93882.1
EMBL· GenBank· DDBJ
Genomic DNA
JX900767
EMBL· GenBank· DDBJ
AGC20996.1
EMBL· GenBank· DDBJ
Genomic DNA
KC763415
EMBL· GenBank· DDBJ
AGR43809.1
EMBL· GenBank· DDBJ
Genomic DNA
KF161169
EMBL· GenBank· DDBJ
AGW55774.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451095
EMBL· GenBank· DDBJ
AGZ67879.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451104
EMBL· GenBank· DDBJ
AGZ67996.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451122
EMBL· GenBank· DDBJ
AGZ68230.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451871
EMBL· GenBank· DDBJ
AGZ77967.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ446282
EMBL· GenBank· DDBJ
AHX49731.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ446283
EMBL· GenBank· DDBJ
AHX49744.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ446284
EMBL· GenBank· DDBJ
AHX49757.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ446285
EMBL· GenBank· DDBJ
AHX49770.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185551
EMBL· GenBank· DDBJ
AID09583.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185926
EMBL· GenBank· DDBJ
AID14458.1
EMBL· GenBank· DDBJ
Genomic DNA
KM078028
EMBL· GenBank· DDBJ
AIS37993.1
EMBL· GenBank· DDBJ
Genomic DNA
KM047191
EMBL· GenBank· DDBJ
AIS38366.1
EMBL· GenBank· DDBJ
Genomic DNA
KX457383
EMBL· GenBank· DDBJ
APD65019.1
EMBL· GenBank· DDBJ
Genomic DNA
KX457391
EMBL· GenBank· DDBJ
APD65123.1
EMBL· GenBank· DDBJ
Genomic DNA
KX457664
EMBL· GenBank· DDBJ
APD68671.1
EMBL· GenBank· DDBJ
Genomic DNA
KY496884
EMBL· GenBank· DDBJ
AQX91548.1
EMBL· GenBank· DDBJ
Genomic DNA
KY496912
EMBL· GenBank· DDBJ
AQX91912.1
EMBL· GenBank· DDBJ
Genomic DNA
KY824909
EMBL· GenBank· DDBJ
ARK16207.1
EMBL· GenBank· DDBJ
Genomic DNA
KY824932
EMBL· GenBank· DDBJ
ARK16506.1
EMBL· GenBank· DDBJ
Genomic DNA
KY967269
EMBL· GenBank· DDBJ
ARM35891.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057283
EMBL· GenBank· DDBJ
ASS13592.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057285
EMBL· GenBank· DDBJ
ASS13618.1
EMBL· GenBank· DDBJ
Genomic DNA
MG637088
EMBL· GenBank· DDBJ
AWD36616.1
EMBL· GenBank· DDBJ
Genomic DNA
MH120602
EMBL· GenBank· DDBJ
AZJ10439.1
EMBL· GenBank· DDBJ
Genomic DNA
MH080305
EMBL· GenBank· DDBJ
AZQ07786.1
EMBL· GenBank· DDBJ
Genomic DNA
MH080306
EMBL· GenBank· DDBJ
AZQ07799.1
EMBL· GenBank· DDBJ
Genomic DNA
MF437163
EMBL· GenBank· DDBJ
QBZ75364.1
EMBL· GenBank· DDBJ
Genomic DNA
MN516567
EMBL· GenBank· DDBJ
QFZ96850.1
EMBL· GenBank· DDBJ
Genomic DNA
MN516620
EMBL· GenBank· DDBJ
QFZ97539.1
EMBL· GenBank· DDBJ
Genomic DNA
MN540485
EMBL· GenBank· DDBJ
QGL53531.1
EMBL· GenBank· DDBJ
Genomic DNA
MN540495
EMBL· GenBank· DDBJ
QGL53661.1
EMBL· GenBank· DDBJ
Genomic DNA
MN046489
EMBL· GenBank· DDBJ
QJX66684.1
EMBL· GenBank· DDBJ
Genomic DNA
MN046513
EMBL· GenBank· DDBJ
QJX66996.1
EMBL· GenBank· DDBJ
Genomic DNA
MN687215
EMBL· GenBank· DDBJ
QLH91634.1
EMBL· GenBank· DDBJ
Genomic DNA
MN687253
EMBL· GenBank· DDBJ
QLH92128.1
EMBL· GenBank· DDBJ
Genomic DNA
MW389251
EMBL· GenBank· DDBJ
QRC36947.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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