Q6VIH9 · Q6VIH9_HUMAN
- ProteinCytochrome b
- GeneCYTB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids380 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 83 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 97 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 182 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 196 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 201 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | respiratory electron transport chain |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6VIH9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 30-56 | Helical | ||||
Sequence: WWNFGSLLGACLILQITTGLFLAMHYS | ||||||
Transmembrane | 77-98 | Helical | ||||
Sequence: WIIRYLHANGASMFFICLFLHI | ||||||
Transmembrane | 113-133 | Helical | ||||
Sequence: WNIGIILLLATMATAFMGYVL | ||||||
Transmembrane | 140-158 | Helical | ||||
Sequence: FWGATVITNLLSAIPYIGA | ||||||
Transmembrane | 178-200 | Helical | ||||
Sequence: FFTFHFILPFIIAALAALHLLFL | ||||||
Transmembrane | 229-246 | Helical | ||||
Sequence: ALGLLLFLLSLMTLTLFS | ||||||
Transmembrane | 288-308 | Helical | ||||
Sequence: LGGVLALLLSILILAMIPILH | ||||||
Transmembrane | 320-339 | Helical | ||||
Sequence: LSQSLYWLLAADLLILTWIG | ||||||
Transmembrane | 345-372 | Helical | ||||
Sequence: YPFTIIGQVASVLYFTTILILMPTISLI |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-209 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: MTPMRKINPLMKLINRSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGADLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPL | ||||||
Domain | 210-380 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length380
- Mass (Da)42,689
- Last updated2004-07-05 v1
- ChecksumBF4200E2234BC1B5
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY339528 EMBL· GenBank· DDBJ | AAP90686.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY339529 EMBL· GenBank· DDBJ | AAP90699.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY882398 EMBL· GenBank· DDBJ | AAW58410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ489510 EMBL· GenBank· DDBJ | ABE99242.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ862536 EMBL· GenBank· DDBJ | ABG91373.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ904330 EMBL· GenBank· DDBJ | ABI32928.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ493508 EMBL· GenBank· DDBJ | ACJ70949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU123032 EMBL· GenBank· DDBJ | ACY55828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM765468 EMBL· GenBank· DDBJ | ADK66632.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM852782 EMBL· GenBank· DDBJ | ADL30244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ384205 EMBL· GenBank· DDBJ | ADO85170.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701866 EMBL· GenBank· DDBJ | AFF62228.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX171115 EMBL· GenBank· DDBJ | AFN87331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX152785 EMBL· GenBank· DDBJ | AFO20390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX297176 EMBL· GenBank· DDBJ | AFP98465.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC257307 EMBL· GenBank· DDBJ | AGE01363.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC286591 EMBL· GenBank· DDBJ | AGE14775.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC533468 EMBL· GenBank· DDBJ | AGK64334.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911325 EMBL· GenBank· DDBJ | AGO90977.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF450864 EMBL· GenBank· DDBJ | AGZ64877.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101751 EMBL· GenBank· DDBJ | AIU59474.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY408162 EMBL· GenBank· DDBJ | AQU15528.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY496867 EMBL· GenBank· DDBJ | AQX91328.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX977302 EMBL· GenBank· DDBJ | AQZ25201.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY083708 EMBL· GenBank· DDBJ | ARB48967.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY782187 EMBL· GenBank· DDBJ | ASC43562.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362706 EMBL· GenBank· DDBJ | ASF83886.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF317873 EMBL· GenBank· DDBJ | ASM81764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF498686 EMBL· GenBank· DDBJ | ASY00533.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF177181 EMBL· GenBank· DDBJ | AUR39831.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG429018 EMBL· GenBank· DDBJ | AUT18549.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG773617 EMBL· GenBank· DDBJ | AWM97052.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG182459 EMBL· GenBank· DDBJ | AXF36471.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH176341 EMBL· GenBank· DDBJ | AXQ02355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059505 EMBL· GenBank· DDBJ | QCB16785.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK491367 EMBL· GenBank· DDBJ | QEG55221.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG778669 EMBL· GenBank· DDBJ | QEU53503.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN503448 EMBL· GenBank· DDBJ | QEW89011.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN516614 EMBL· GenBank· DDBJ | QFZ97462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN540471 EMBL· GenBank· DDBJ | QGL53350.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT079030 EMBL· GenBank· DDBJ | QIV21358.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN046416 EMBL· GenBank· DDBJ | QJX65736.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK617227 EMBL· GenBank· DDBJ | QKN99411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687157 EMBL· GenBank· DDBJ | QLH90881.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN857318 EMBL· GenBank· DDBJ | QTK14701.1 EMBL· GenBank· DDBJ | Genomic DNA |