Q6VIH9 · Q6VIH9_HUMAN

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

138050100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processrespiratory electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      CYTB
    • Synonyms
      CYB
      , MTCYB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 3179
    • F127
    • F128
    • BG-I-8
    • CHP305_Chachapoya
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6VIH9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-56Helical
Transmembrane77-98Helical
Transmembrane113-133Helical
Transmembrane140-158Helical
Transmembrane178-200Helical
Transmembrane229-246Helical
Transmembrane288-308Helical
Transmembrane320-339Helical
Transmembrane345-372Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-380Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    42,689
  • Last updated
    2004-07-05 v1
  • Checksum
    BF4200E2234BC1B5
MTPMRKINPLMKLINRSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGADLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY339528
EMBL· GenBank· DDBJ
AAP90686.1
EMBL· GenBank· DDBJ
Genomic DNA
AY339529
EMBL· GenBank· DDBJ
AAP90699.2
EMBL· GenBank· DDBJ
Genomic DNA
AY882398
EMBL· GenBank· DDBJ
AAW58410.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ489510
EMBL· GenBank· DDBJ
ABE99242.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ862536
EMBL· GenBank· DDBJ
ABG91373.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ904330
EMBL· GenBank· DDBJ
ABI32928.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ493508
EMBL· GenBank· DDBJ
ACJ70949.1
EMBL· GenBank· DDBJ
Genomic DNA
GU123032
EMBL· GenBank· DDBJ
ACY55828.1
EMBL· GenBank· DDBJ
Genomic DNA
HM765468
EMBL· GenBank· DDBJ
ADK66632.1
EMBL· GenBank· DDBJ
Genomic DNA
HM852782
EMBL· GenBank· DDBJ
ADL30244.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ384205
EMBL· GenBank· DDBJ
ADO85170.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ701866
EMBL· GenBank· DDBJ
AFF62228.1
EMBL· GenBank· DDBJ
Genomic DNA
JX171115
EMBL· GenBank· DDBJ
AFN87331.1
EMBL· GenBank· DDBJ
Genomic DNA
JX152785
EMBL· GenBank· DDBJ
AFO20390.1
EMBL· GenBank· DDBJ
Genomic DNA
JX297176
EMBL· GenBank· DDBJ
AFP98465.1
EMBL· GenBank· DDBJ
Genomic DNA
KC257307
EMBL· GenBank· DDBJ
AGE01363.1
EMBL· GenBank· DDBJ
Genomic DNA
KC286591
EMBL· GenBank· DDBJ
AGE14775.1
EMBL· GenBank· DDBJ
Genomic DNA
KC533468
EMBL· GenBank· DDBJ
AGK64334.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911325
EMBL· GenBank· DDBJ
AGO90977.1
EMBL· GenBank· DDBJ
Genomic DNA
KF450864
EMBL· GenBank· DDBJ
AGZ64877.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101751
EMBL· GenBank· DDBJ
AIU59474.1
EMBL· GenBank· DDBJ
Genomic DNA
KY408162
EMBL· GenBank· DDBJ
AQU15528.1
EMBL· GenBank· DDBJ
Genomic DNA
KY496867
EMBL· GenBank· DDBJ
AQX91328.1
EMBL· GenBank· DDBJ
Genomic DNA
KX977302
EMBL· GenBank· DDBJ
AQZ25201.1
EMBL· GenBank· DDBJ
Genomic DNA
KY083708
EMBL· GenBank· DDBJ
ARB48967.1
EMBL· GenBank· DDBJ
Genomic DNA
KY782187
EMBL· GenBank· DDBJ
ASC43562.1
EMBL· GenBank· DDBJ
Genomic DNA
MF362706
EMBL· GenBank· DDBJ
ASF83886.1
EMBL· GenBank· DDBJ
Genomic DNA
MF317873
EMBL· GenBank· DDBJ
ASM81764.1
EMBL· GenBank· DDBJ
Genomic DNA
MF498686
EMBL· GenBank· DDBJ
ASY00533.1
EMBL· GenBank· DDBJ
Genomic DNA
MF177181
EMBL· GenBank· DDBJ
AUR39831.1
EMBL· GenBank· DDBJ
Genomic DNA
MG429018
EMBL· GenBank· DDBJ
AUT18549.1
EMBL· GenBank· DDBJ
Genomic DNA
MG773617
EMBL· GenBank· DDBJ
AWM97052.1
EMBL· GenBank· DDBJ
Genomic DNA
MG182459
EMBL· GenBank· DDBJ
AXF36471.1
EMBL· GenBank· DDBJ
Genomic DNA
MH176341
EMBL· GenBank· DDBJ
AXQ02355.1
EMBL· GenBank· DDBJ
Genomic DNA
MK059505
EMBL· GenBank· DDBJ
QCB16785.1
EMBL· GenBank· DDBJ
Genomic DNA
MK491367
EMBL· GenBank· DDBJ
QEG55221.1
EMBL· GenBank· DDBJ
Genomic DNA
MG778669
EMBL· GenBank· DDBJ
QEU53503.1
EMBL· GenBank· DDBJ
Genomic DNA
MN503448
EMBL· GenBank· DDBJ
QEW89011.1
EMBL· GenBank· DDBJ
Genomic DNA
MN516614
EMBL· GenBank· DDBJ
QFZ97462.1
EMBL· GenBank· DDBJ
Genomic DNA
MN540471
EMBL· GenBank· DDBJ
QGL53350.1
EMBL· GenBank· DDBJ
Genomic DNA
MT079030
EMBL· GenBank· DDBJ
QIV21358.1
EMBL· GenBank· DDBJ
Genomic DNA
MN046416
EMBL· GenBank· DDBJ
QJX65736.1
EMBL· GenBank· DDBJ
Genomic DNA
MK617227
EMBL· GenBank· DDBJ
QKN99411.1
EMBL· GenBank· DDBJ
Genomic DNA
MN687157
EMBL· GenBank· DDBJ
QLH90881.1
EMBL· GenBank· DDBJ
Genomic DNA
MN857318
EMBL· GenBank· DDBJ
QTK14701.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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