Q6VI47 · Q6VI47_HUMAN

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

138050100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processrespiratory electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      CYTB
    • Synonyms
      CYB
      , MTCYB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 2065
    • KR101
    • PaEMB9947
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6VI47

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-56Helical
Transmembrane77-98Helical
Transmembrane113-133Helical
Transmembrane140-158Helical
Transmembrane178-200Helical
Transmembrane229-246Helical
Transmembrane288-308Helical
Transmembrane320-339Helical
Transmembrane345-372Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-380Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    42,666
  • Last updated
    2004-07-05 v1
  • Checksum
    D4F50314AAB3ABA1
MTPMRKINPLMKLINHSLIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY339554
EMBL· GenBank· DDBJ
AAP91024.1
EMBL· GenBank· DDBJ
Genomic DNA
AY339555
EMBL· GenBank· DDBJ
AAP91037.1
EMBL· GenBank· DDBJ
Genomic DNA
AY882395
EMBL· GenBank· DDBJ
AAW58371.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ489515
EMBL· GenBank· DDBJ
ABE99307.1
EMBL· GenBank· DDBJ
Genomic DNA
EU273489
EMBL· GenBank· DDBJ
ABX40222.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ460525
EMBL· GenBank· DDBJ
ACJ47311.1
EMBL· GenBank· DDBJ
Genomic DNA
GU213255
EMBL· GenBank· DDBJ
ADA58668.1
EMBL· GenBank· DDBJ
Genomic DNA
GU592026
EMBL· GenBank· DDBJ
ADD54122.1
EMBL· GenBank· DDBJ
Genomic DNA
HM030520
EMBL· GenBank· DDBJ
ADE33350.1
EMBL· GenBank· DDBJ
Genomic DNA
HM103359
EMBL· GenBank· DDBJ
ADG22897.1
EMBL· GenBank· DDBJ
Genomic DNA
HM765466
EMBL· GenBank· DDBJ
ADK66606.1
EMBL· GenBank· DDBJ
Genomic DNA
HM625683
EMBL· GenBank· DDBJ
ADK77245.1
EMBL· GenBank· DDBJ
Genomic DNA
HM852763
EMBL· GenBank· DDBJ
ADL29997.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ012066
EMBL· GenBank· DDBJ
ADM58811.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ287881
EMBL· GenBank· DDBJ
ADO50810.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ384197
EMBL· GenBank· DDBJ
ADO85066.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675035
EMBL· GenBank· DDBJ
AEN03498.1
EMBL· GenBank· DDBJ
Genomic DNA
JN415475
EMBL· GenBank· DDBJ
AEO31634.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ664545
EMBL· GenBank· DDBJ
AFC98141.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ701808
EMBL· GenBank· DDBJ
AFF61474.1
EMBL· GenBank· DDBJ
Genomic DNA
JX171126
EMBL· GenBank· DDBJ
AFN87474.1
EMBL· GenBank· DDBJ
Genomic DNA
JX152800
EMBL· GenBank· DDBJ
AFO20585.1
EMBL· GenBank· DDBJ
Genomic DNA
JX273246
EMBL· GenBank· DDBJ
AFP91245.1
EMBL· GenBank· DDBJ
Genomic DNA
JX297145
EMBL· GenBank· DDBJ
AFP98062.1
EMBL· GenBank· DDBJ
Genomic DNA
KC257379
EMBL· GenBank· DDBJ
AGE02299.1
EMBL· GenBank· DDBJ
Genomic DNA
KC286592
EMBL· GenBank· DDBJ
AGE14788.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911309
EMBL· GenBank· DDBJ
AGO90769.1
EMBL· GenBank· DDBJ
Genomic DNA
KF146251
EMBL· GenBank· DDBJ
AGT53918.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252554
EMBL· GenBank· DDBJ
AGX92591.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540841
EMBL· GenBank· DDBJ
AGZ10237.1
EMBL· GenBank· DDBJ
Genomic DNA
KF450905
EMBL· GenBank· DDBJ
AGZ65410.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ154370
EMBL· GenBank· DDBJ
AHW32481.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ735676
EMBL· GenBank· DDBJ
AIH01111.1
EMBL· GenBank· DDBJ
Genomic DNA
KM103657
EMBL· GenBank· DDBJ
AIK67071.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ801421
EMBL· GenBank· DDBJ
AIL91343.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ856676
EMBL· GenBank· DDBJ
AIN37293.1
EMBL· GenBank· DDBJ
Genomic DNA
KM047228
EMBL· GenBank· DDBJ
AIS38848.1
EMBL· GenBank· DDBJ
Genomic DNA
KM371020
EMBL· GenBank· DDBJ
AIS75021.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101710
EMBL· GenBank· DDBJ
AIU58941.1
EMBL· GenBank· DDBJ
Genomic DNA
KT749781
EMBL· GenBank· DDBJ
ALH18188.1
EMBL· GenBank· DDBJ
Genomic DNA
KT819242
EMBL· GenBank· DDBJ
ALM03705.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725867
EMBL· GenBank· DDBJ
ANA92088.1
EMBL· GenBank· DDBJ
Genomic DNA
KX079702
EMBL· GenBank· DDBJ
ANB32544.1
EMBL· GenBank· DDBJ
Genomic DNA
KX450778
EMBL· GenBank· DDBJ
AOZ57979.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456932
EMBL· GenBank· DDBJ
APD59157.1
EMBL· GenBank· DDBJ
Genomic DNA
KX675284
EMBL· GenBank· DDBJ
APZ83400.1
EMBL· GenBank· DDBJ
Genomic DNA
KY399156
EMBL· GenBank· DDBJ
AQU13257.1
EMBL· GenBank· DDBJ
Genomic DNA
KY496914
EMBL· GenBank· DDBJ
AQX91939.1
EMBL· GenBank· DDBJ
Genomic DNA
KY091897
EMBL· GenBank· DDBJ
AQZ60056.1
EMBL· GenBank· DDBJ
Genomic DNA
KY083721
EMBL· GenBank· DDBJ
ARB49136.1
EMBL· GenBank· DDBJ
Genomic DNA
KY595670
EMBL· GenBank· DDBJ
ARD73346.1
EMBL· GenBank· DDBJ
Genomic DNA
KY825065
EMBL· GenBank· DDBJ
ARK18235.1
EMBL· GenBank· DDBJ
Genomic DNA
KY411453
EMBL· GenBank· DDBJ
ARM19077.1
EMBL· GenBank· DDBJ
Genomic DNA
KY782173
EMBL· GenBank· DDBJ
ASC43380.1
EMBL· GenBank· DDBJ
Genomic DNA
MF362698
EMBL· GenBank· DDBJ
ASF83782.1
EMBL· GenBank· DDBJ
Genomic DNA
MF362907
EMBL· GenBank· DDBJ
ASF86497.1
EMBL· GenBank· DDBJ
Genomic DNA
MF497485
EMBL· GenBank· DDBJ
ASQ39315.1
EMBL· GenBank· DDBJ
Genomic DNA
MF498671
EMBL· GenBank· DDBJ
ASY00338.1
EMBL· GenBank· DDBJ
Genomic DNA
KY797171
EMBL· GenBank· DDBJ
AUG82371.1
EMBL· GenBank· DDBJ
Genomic DNA
MF177147
EMBL· GenBank· DDBJ
AUR39389.1
EMBL· GenBank· DDBJ
Genomic DNA
MG428997
EMBL· GenBank· DDBJ
AUT18276.1
EMBL· GenBank· DDBJ
Genomic DNA
MG244208
EMBL· GenBank· DDBJ
AUZ22853.1
EMBL· GenBank· DDBJ
Genomic DNA
MF991436
EMBL· GenBank· DDBJ
AWW03245.1
EMBL· GenBank· DDBJ
Genomic DNA
MG952785
EMBL· GenBank· DDBJ
AWX64195.1
EMBL· GenBank· DDBJ
Genomic DNA
MG182462
EMBL· GenBank· DDBJ
AXF36509.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449381
EMBL· GenBank· DDBJ
AYW09674.1
EMBL· GenBank· DDBJ
Genomic DNA
MH043561
EMBL· GenBank· DDBJ
AZM31790.1
EMBL· GenBank· DDBJ
Genomic DNA
HE576978
EMBL· GenBank· DDBJ
CCC82756.1
EMBL· GenBank· DDBJ
Genomic DNA
MK321345
EMBL· GenBank· DDBJ
QAV57541.1
EMBL· GenBank· DDBJ
Genomic DNA
MK059508
EMBL· GenBank· DDBJ
QCB16824.1
EMBL· GenBank· DDBJ
Genomic DNA
MK491384
EMBL· GenBank· DDBJ
QEG55442.1
EMBL· GenBank· DDBJ
Genomic DNA
MN503458
EMBL· GenBank· DDBJ
QEW89141.1
EMBL· GenBank· DDBJ
Genomic DNA
MK248287
EMBL· GenBank· DDBJ
QFV14524.1
EMBL· GenBank· DDBJ
Genomic DNA
MN516623
EMBL· GenBank· DDBJ
QFZ97579.1
EMBL· GenBank· DDBJ
Genomic DNA
MN540472
EMBL· GenBank· DDBJ
QGL53363.1
EMBL· GenBank· DDBJ
Genomic DNA
MN398799
EMBL· GenBank· DDBJ
QIQ24946.1
EMBL· GenBank· DDBJ
Genomic DNA
MT079026
EMBL· GenBank· DDBJ
QIV21306.1
EMBL· GenBank· DDBJ
Genomic DNA
MN046511
EMBL· GenBank· DDBJ
QJX66971.1
EMBL· GenBank· DDBJ
Genomic DNA
MK617242
EMBL· GenBank· DDBJ
QKN99606.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849716
EMBL· GenBank· DDBJ
QKT24854.1
EMBL· GenBank· DDBJ
Genomic DNA
MN610408
EMBL· GenBank· DDBJ
QLA48443.1
EMBL· GenBank· DDBJ
Genomic DNA
MN687223
EMBL· GenBank· DDBJ
QLH91739.1
EMBL· GenBank· DDBJ
Genomic DNA
MT419101
EMBL· GenBank· DDBJ
QMP92846.1
EMBL· GenBank· DDBJ
Genomic DNA
MT902328
EMBL· GenBank· DDBJ
QSQ70904.1
EMBL· GenBank· DDBJ
Genomic DNA
MW467809
EMBL· GenBank· DDBJ
QTK29436.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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