Q6VI47 · Q6VI47_HUMAN
- ProteinCytochrome b
- GeneCYTB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids380 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 83 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 97 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 182 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 196 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 201 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | respiratory electron transport chain |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6VI47
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 30-56 | Helical | ||||
Sequence: WWNFGSLLGACLILQITTGLFLAMHYS | ||||||
Transmembrane | 77-98 | Helical | ||||
Sequence: WIIRYLHANGASMFFICLFLHI | ||||||
Transmembrane | 113-133 | Helical | ||||
Sequence: WNIGIILLLATMATAFMGYVL | ||||||
Transmembrane | 140-158 | Helical | ||||
Sequence: FWGATVITNLLSAIPYIGT | ||||||
Transmembrane | 178-200 | Helical | ||||
Sequence: FFTFHFILPFIIAALAALHLLFL | ||||||
Transmembrane | 229-246 | Helical | ||||
Sequence: ALGLLLFLLSLMTLTLFS | ||||||
Transmembrane | 288-308 | Helical | ||||
Sequence: LGGVLALLLSILILAMIPILH | ||||||
Transmembrane | 320-339 | Helical | ||||
Sequence: LSQSLYWLLAADLLILTWIG | ||||||
Transmembrane | 345-372 | Helical | ||||
Sequence: YPFTIIGQVASVLYFTTILILMPTISLI |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-209 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: MTPMRKINPLMKLINHSLIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPL | ||||||
Domain | 210-380 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length380
- Mass (Da)42,666
- Last updated2004-07-05 v1
- ChecksumD4F50314AAB3ABA1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY339554 EMBL· GenBank· DDBJ | AAP91024.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY339555 EMBL· GenBank· DDBJ | AAP91037.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY882395 EMBL· GenBank· DDBJ | AAW58371.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ489515 EMBL· GenBank· DDBJ | ABE99307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU273489 EMBL· GenBank· DDBJ | ABX40222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ460525 EMBL· GenBank· DDBJ | ACJ47311.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU213255 EMBL· GenBank· DDBJ | ADA58668.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU592026 EMBL· GenBank· DDBJ | ADD54122.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM030520 EMBL· GenBank· DDBJ | ADE33350.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM103359 EMBL· GenBank· DDBJ | ADG22897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM765466 EMBL· GenBank· DDBJ | ADK66606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM625683 EMBL· GenBank· DDBJ | ADK77245.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM852763 EMBL· GenBank· DDBJ | ADL29997.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012066 EMBL· GenBank· DDBJ | ADM58811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ287881 EMBL· GenBank· DDBJ | ADO50810.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ384197 EMBL· GenBank· DDBJ | ADO85066.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675035 EMBL· GenBank· DDBJ | AEN03498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN415475 EMBL· GenBank· DDBJ | AEO31634.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ664545 EMBL· GenBank· DDBJ | AFC98141.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701808 EMBL· GenBank· DDBJ | AFF61474.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX171126 EMBL· GenBank· DDBJ | AFN87474.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX152800 EMBL· GenBank· DDBJ | AFO20585.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX273246 EMBL· GenBank· DDBJ | AFP91245.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX297145 EMBL· GenBank· DDBJ | AFP98062.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC257379 EMBL· GenBank· DDBJ | AGE02299.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC286592 EMBL· GenBank· DDBJ | AGE14788.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911309 EMBL· GenBank· DDBJ | AGO90769.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF146251 EMBL· GenBank· DDBJ | AGT53918.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252554 EMBL· GenBank· DDBJ | AGX92591.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540841 EMBL· GenBank· DDBJ | AGZ10237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF450905 EMBL· GenBank· DDBJ | AGZ65410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ154370 EMBL· GenBank· DDBJ | AHW32481.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ735676 EMBL· GenBank· DDBJ | AIH01111.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM103657 EMBL· GenBank· DDBJ | AIK67071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ801421 EMBL· GenBank· DDBJ | AIL91343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ856676 EMBL· GenBank· DDBJ | AIN37293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM047228 EMBL· GenBank· DDBJ | AIS38848.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM371020 EMBL· GenBank· DDBJ | AIS75021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101710 EMBL· GenBank· DDBJ | AIU58941.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT749781 EMBL· GenBank· DDBJ | ALH18188.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT819242 EMBL· GenBank· DDBJ | ALM03705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725867 EMBL· GenBank· DDBJ | ANA92088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX079702 EMBL· GenBank· DDBJ | ANB32544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX450778 EMBL· GenBank· DDBJ | AOZ57979.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456932 EMBL· GenBank· DDBJ | APD59157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX675284 EMBL· GenBank· DDBJ | APZ83400.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY399156 EMBL· GenBank· DDBJ | AQU13257.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY496914 EMBL· GenBank· DDBJ | AQX91939.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY091897 EMBL· GenBank· DDBJ | AQZ60056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY083721 EMBL· GenBank· DDBJ | ARB49136.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY595670 EMBL· GenBank· DDBJ | ARD73346.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY825065 EMBL· GenBank· DDBJ | ARK18235.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY411453 EMBL· GenBank· DDBJ | ARM19077.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY782173 EMBL· GenBank· DDBJ | ASC43380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362698 EMBL· GenBank· DDBJ | ASF83782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362907 EMBL· GenBank· DDBJ | ASF86497.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF497485 EMBL· GenBank· DDBJ | ASQ39315.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF498671 EMBL· GenBank· DDBJ | ASY00338.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY797171 EMBL· GenBank· DDBJ | AUG82371.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF177147 EMBL· GenBank· DDBJ | AUR39389.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG428997 EMBL· GenBank· DDBJ | AUT18276.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG244208 EMBL· GenBank· DDBJ | AUZ22853.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF991436 EMBL· GenBank· DDBJ | AWW03245.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG952785 EMBL· GenBank· DDBJ | AWX64195.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG182462 EMBL· GenBank· DDBJ | AXF36509.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449381 EMBL· GenBank· DDBJ | AYW09674.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH043561 EMBL· GenBank· DDBJ | AZM31790.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE576978 EMBL· GenBank· DDBJ | CCC82756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK321345 EMBL· GenBank· DDBJ | QAV57541.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059508 EMBL· GenBank· DDBJ | QCB16824.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK491384 EMBL· GenBank· DDBJ | QEG55442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN503458 EMBL· GenBank· DDBJ | QEW89141.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK248287 EMBL· GenBank· DDBJ | QFV14524.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN516623 EMBL· GenBank· DDBJ | QFZ97579.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN540472 EMBL· GenBank· DDBJ | QGL53363.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN398799 EMBL· GenBank· DDBJ | QIQ24946.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT079026 EMBL· GenBank· DDBJ | QIV21306.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN046511 EMBL· GenBank· DDBJ | QJX66971.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK617242 EMBL· GenBank· DDBJ | QKN99606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849716 EMBL· GenBank· DDBJ | QKT24854.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN610408 EMBL· GenBank· DDBJ | QLA48443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687223 EMBL· GenBank· DDBJ | QLH91739.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT419101 EMBL· GenBank· DDBJ | QMP92846.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT902328 EMBL· GenBank· DDBJ | QSQ70904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW467809 EMBL· GenBank· DDBJ | QTK29436.1 EMBL· GenBank· DDBJ | Genomic DNA |