Q6VHV2 · Q6VHV2_HUMAN
- ProteinCytochrome c oxidase subunit 1
- GeneCOX1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids513 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6VHV2
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | ||||
Sequence: LYLLFGAWAGVLGTALSLLI | ||||||
Transmembrane | 57-83 | Helical | ||||
Sequence: IVTAHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 104-126 | Helical | ||||
Sequence: LLPPSLLLLLASAMVEAGAGTGW | ||||||
Transmembrane | 146-171 | Helical | ||||
Sequence: IIFSLHLAGVSSILGAINFITTIINM | ||||||
Transmembrane | 183-210 | Helical | ||||
Sequence: LFVWSVLITAVLLLLSLPVLAAGITMLL | ||||||
Transmembrane | 243-261 | Helical | ||||
Sequence: VYILILPGFGMISHIVTYY | ||||||
Transmembrane | 268-291 | Helical | ||||
Sequence: FGYMGMVWAMMSIGFLGFIVWAHH | ||||||
Transmembrane | 303-325 | Helical | ||||
Sequence: AYFTSATMIIAIPTGVKVFSWLA | ||||||
Transmembrane | 337-359 | Helical | ||||
Sequence: AVLWALGFIFLFTVGGLTGIVLA | ||||||
Transmembrane | 379-400 | Helical | ||||
Sequence: YVLSMGAVFAIMGGFIHWFPLF | ||||||
Transmembrane | 412-430 | Helical | ||||
Sequence: IHFTIMFIGVNLTFFPQHF | ||||||
Transmembrane | 450-473 | Helical | ||||
Sequence: WNILSSVGSFISLTAVMLMIFMIW |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-511 | Cytochrome oxidase subunit I profile | ||||
Sequence: MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLIIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYM |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length513
- Mass (Da)57,053
- Last updated2004-07-05 v1
- ChecksumD08B485E89A3A1F1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY339565 EMBL· GenBank· DDBJ | AAP91157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF060350 EMBL· GenBank· DDBJ | ABJ89449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF093535 EMBL· GenBank· DDBJ | ABL61582.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF093536 EMBL· GenBank· DDBJ | ABL61595.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657522 EMBL· GenBank· DDBJ | ABR96749.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383536 EMBL· GenBank· DDBJ | ACM74096.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383537 EMBL· GenBank· DDBJ | ACM74109.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383538 EMBL· GenBank· DDBJ | ACM74122.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383539 EMBL· GenBank· DDBJ | ACM74135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383540 EMBL· GenBank· DDBJ | ACM74148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ951544 EMBL· GenBank· DDBJ | ACQ75285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM775494 EMBL· GenBank· DDBJ | ADK47863.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM036559 EMBL· GenBank· DDBJ | ADK73027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM852882 EMBL· GenBank· DDBJ | ADL31534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012241 EMBL· GenBank· DDBJ | ADM61076.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN214423 EMBL· GenBank· DDBJ | AEP23517.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN857039 EMBL· GenBank· DDBJ | AET09349.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ704452 EMBL· GenBank· DDBJ | AFF95836.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705067 EMBL· GenBank· DDBJ | AFG03831.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ798051 EMBL· GenBank· DDBJ | AFI53413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153285 EMBL· GenBank· DDBJ | AFO26880.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX669176 EMBL· GenBank· DDBJ | AFV54003.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC503926 EMBL· GenBank· DDBJ | AGH18584.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC964603 EMBL· GenBank· DDBJ | AGK41192.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF171123 EMBL· GenBank· DDBJ | AGN53292.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF161153 EMBL· GenBank· DDBJ | AGW55557.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF162590 EMBL· GenBank· DDBJ | AGW74237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252342 EMBL· GenBank· DDBJ | AGX89825.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252360 EMBL· GenBank· DDBJ | AGX90059.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252414 EMBL· GenBank· DDBJ | AGX90761.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252422 EMBL· GenBank· DDBJ | AGX90865.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252441 EMBL· GenBank· DDBJ | AGX91112.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252445 EMBL· GenBank· DDBJ | AGX91164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252471 EMBL· GenBank· DDBJ | AGX91502.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252495 EMBL· GenBank· DDBJ | AGX91814.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252540 EMBL· GenBank· DDBJ | AGX92399.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540514 EMBL· GenBank· DDBJ | AGZ05976.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540524 EMBL· GenBank· DDBJ | AGZ06106.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540532 EMBL· GenBank· DDBJ | AGZ06210.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540543 EMBL· GenBank· DDBJ | AGZ06353.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540549 EMBL· GenBank· DDBJ | AGZ06431.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540809 EMBL· GenBank· DDBJ | AGZ09811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF849972 EMBL· GenBank· DDBJ | AHE79526.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP691986 EMBL· GenBank· DDBJ | AJF40067.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP317029 EMBL· GenBank· DDBJ | AJT35983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP763847 EMBL· GenBank· DDBJ | AKB98897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT819221 EMBL· GenBank· DDBJ | ALM03422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU523269 EMBL· GenBank· DDBJ | AMN85910.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456765 EMBL· GenBank· DDBJ | APD56977.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456886 EMBL· GenBank· DDBJ | APD58549.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457378 EMBL· GenBank· DDBJ | APD64945.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457392 EMBL· GenBank· DDBJ | APD65127.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY824881 EMBL· GenBank· DDBJ | ARK15834.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF055780 EMBL· GenBank· DDBJ | ASR94067.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF055957 EMBL· GenBank· DDBJ | ASR96368.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056587 EMBL· GenBank· DDBJ | ASS04560.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056669 EMBL· GenBank· DDBJ | ASS05626.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056768 EMBL· GenBank· DDBJ | ASS06900.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056810 EMBL· GenBank· DDBJ | ASS07446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056818 EMBL· GenBank· DDBJ | ASS07550.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056843 EMBL· GenBank· DDBJ | ASS07875.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057119 EMBL· GenBank· DDBJ | ASS11451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057332 EMBL· GenBank· DDBJ | ASS14220.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057848 EMBL· GenBank· DDBJ | ASS21111.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057856 EMBL· GenBank· DDBJ | ASS21215.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057862 EMBL· GenBank· DDBJ | ASS21293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057994 EMBL· GenBank· DDBJ | ASS23009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF058081 EMBL· GenBank· DDBJ | ASS24140.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF058375 EMBL· GenBank· DDBJ | ASS27949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF522911 EMBL· GenBank· DDBJ | ATL17948.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF522936 EMBL· GenBank· DDBJ | ATL18273.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF043513 EMBL· GenBank· DDBJ | ATP02664.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG767170 EMBL· GenBank· DDBJ | AUR53850.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH120591 EMBL· GenBank· DDBJ | AZJ10287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH981824 EMBL· GenBank· DDBJ | AZJ13684.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG652751 EMBL· GenBank· DDBJ | QAT98036.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF437105 EMBL· GenBank· DDBJ | QBZ74601.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF437160 EMBL· GenBank· DDBJ | QBZ75316.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF437194 EMBL· GenBank· DDBJ | QBZ75758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF437258 EMBL· GenBank· DDBJ | QBZ76590.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF437267 EMBL· GenBank· DDBJ | QBZ76707.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK134360 EMBL· GenBank· DDBJ | QGW54977.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849804 EMBL· GenBank· DDBJ | QKT25988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW389270 EMBL· GenBank· DDBJ | QRC37185.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW291666 EMBL· GenBank· DDBJ | QVD40193.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN482524 EMBL· GenBank· DDBJ | QXE40396.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN628073 EMBL· GenBank· DDBJ | QXO91513.1 EMBL· GenBank· DDBJ | Genomic DNA |