Q6VHV2 · Q6VHV2_HUMAN

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1
    • Synonyms
      COI
      , MTCO1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • F164
    • MTDNA361
    • 39_M1a5
    • Am012
    • AM038
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6VHV2

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-126Helical
Transmembrane146-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

PTM/Processing

Proteomic databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    57,053
  • Last updated
    2004-07-05 v1
  • Checksum
    D08B485E89A3A1F1
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLIIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY339565
EMBL· GenBank· DDBJ
AAP91157.1
EMBL· GenBank· DDBJ
Genomic DNA
EF060350
EMBL· GenBank· DDBJ
ABJ89449.1
EMBL· GenBank· DDBJ
Genomic DNA
EF093535
EMBL· GenBank· DDBJ
ABL61582.1
EMBL· GenBank· DDBJ
Genomic DNA
EF093536
EMBL· GenBank· DDBJ
ABL61595.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657522
EMBL· GenBank· DDBJ
ABR96749.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383536
EMBL· GenBank· DDBJ
ACM74096.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383537
EMBL· GenBank· DDBJ
ACM74109.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383538
EMBL· GenBank· DDBJ
ACM74122.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383539
EMBL· GenBank· DDBJ
ACM74135.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383540
EMBL· GenBank· DDBJ
ACM74148.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ951544
EMBL· GenBank· DDBJ
ACQ75285.1
EMBL· GenBank· DDBJ
Genomic DNA
HM775494
EMBL· GenBank· DDBJ
ADK47863.1
EMBL· GenBank· DDBJ
Genomic DNA
HM036559
EMBL· GenBank· DDBJ
ADK73027.1
EMBL· GenBank· DDBJ
Genomic DNA
HM852882
EMBL· GenBank· DDBJ
ADL31534.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ012241
EMBL· GenBank· DDBJ
ADM61076.1
EMBL· GenBank· DDBJ
Genomic DNA
JN214423
EMBL· GenBank· DDBJ
AEP23517.1
EMBL· GenBank· DDBJ
Genomic DNA
JN857039
EMBL· GenBank· DDBJ
AET09349.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ704452
EMBL· GenBank· DDBJ
AFF95836.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705067
EMBL· GenBank· DDBJ
AFG03831.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ798051
EMBL· GenBank· DDBJ
AFI53413.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153285
EMBL· GenBank· DDBJ
AFO26880.1
EMBL· GenBank· DDBJ
Genomic DNA
JX669176
EMBL· GenBank· DDBJ
AFV54003.1
EMBL· GenBank· DDBJ
Genomic DNA
KC503926
EMBL· GenBank· DDBJ
AGH18584.1
EMBL· GenBank· DDBJ
Genomic DNA
KC964603
EMBL· GenBank· DDBJ
AGK41192.1
EMBL· GenBank· DDBJ
Genomic DNA
KF171123
EMBL· GenBank· DDBJ
AGN53292.1
EMBL· GenBank· DDBJ
Genomic DNA
KF161153
EMBL· GenBank· DDBJ
AGW55557.1
EMBL· GenBank· DDBJ
Genomic DNA
KF162590
EMBL· GenBank· DDBJ
AGW74237.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252342
EMBL· GenBank· DDBJ
AGX89825.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252360
EMBL· GenBank· DDBJ
AGX90059.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252414
EMBL· GenBank· DDBJ
AGX90761.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252422
EMBL· GenBank· DDBJ
AGX90865.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252441
EMBL· GenBank· DDBJ
AGX91112.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252445
EMBL· GenBank· DDBJ
AGX91164.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252471
EMBL· GenBank· DDBJ
AGX91502.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252495
EMBL· GenBank· DDBJ
AGX91814.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252540
EMBL· GenBank· DDBJ
AGX92399.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540514
EMBL· GenBank· DDBJ
AGZ05976.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540524
EMBL· GenBank· DDBJ
AGZ06106.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540532
EMBL· GenBank· DDBJ
AGZ06210.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540543
EMBL· GenBank· DDBJ
AGZ06353.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540549
EMBL· GenBank· DDBJ
AGZ06431.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540809
EMBL· GenBank· DDBJ
AGZ09811.1
EMBL· GenBank· DDBJ
Genomic DNA
KF849972
EMBL· GenBank· DDBJ
AHE79526.1
EMBL· GenBank· DDBJ
Genomic DNA
KP691986
EMBL· GenBank· DDBJ
AJF40067.1
EMBL· GenBank· DDBJ
Genomic DNA
KP317029
EMBL· GenBank· DDBJ
AJT35983.1
EMBL· GenBank· DDBJ
Genomic DNA
KP763847
EMBL· GenBank· DDBJ
AKB98897.1
EMBL· GenBank· DDBJ
Genomic DNA
KT819221
EMBL· GenBank· DDBJ
ALM03422.1
EMBL· GenBank· DDBJ
Genomic DNA
KU523269
EMBL· GenBank· DDBJ
AMN85910.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456765
EMBL· GenBank· DDBJ
APD56977.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456886
EMBL· GenBank· DDBJ
APD58549.1
EMBL· GenBank· DDBJ
Genomic DNA
KX457378
EMBL· GenBank· DDBJ
APD64945.1
EMBL· GenBank· DDBJ
Genomic DNA
KX457392
EMBL· GenBank· DDBJ
APD65127.1
EMBL· GenBank· DDBJ
Genomic DNA
KY824881
EMBL· GenBank· DDBJ
ARK15834.1
EMBL· GenBank· DDBJ
Genomic DNA
MF055780
EMBL· GenBank· DDBJ
ASR94067.1
EMBL· GenBank· DDBJ
Genomic DNA
MF055957
EMBL· GenBank· DDBJ
ASR96368.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056587
EMBL· GenBank· DDBJ
ASS04560.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056669
EMBL· GenBank· DDBJ
ASS05626.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056768
EMBL· GenBank· DDBJ
ASS06900.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056810
EMBL· GenBank· DDBJ
ASS07446.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056818
EMBL· GenBank· DDBJ
ASS07550.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056843
EMBL· GenBank· DDBJ
ASS07875.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057119
EMBL· GenBank· DDBJ
ASS11451.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057332
EMBL· GenBank· DDBJ
ASS14220.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057848
EMBL· GenBank· DDBJ
ASS21111.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057856
EMBL· GenBank· DDBJ
ASS21215.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057862
EMBL· GenBank· DDBJ
ASS21293.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057994
EMBL· GenBank· DDBJ
ASS23009.1
EMBL· GenBank· DDBJ
Genomic DNA
MF058081
EMBL· GenBank· DDBJ
ASS24140.1
EMBL· GenBank· DDBJ
Genomic DNA
MF058375
EMBL· GenBank· DDBJ
ASS27949.1
EMBL· GenBank· DDBJ
Genomic DNA
MF522911
EMBL· GenBank· DDBJ
ATL17948.1
EMBL· GenBank· DDBJ
Genomic DNA
MF522936
EMBL· GenBank· DDBJ
ATL18273.1
EMBL· GenBank· DDBJ
Genomic DNA
MF043513
EMBL· GenBank· DDBJ
ATP02664.1
EMBL· GenBank· DDBJ
Genomic DNA
MG767170
EMBL· GenBank· DDBJ
AUR53850.1
EMBL· GenBank· DDBJ
Genomic DNA
MH120591
EMBL· GenBank· DDBJ
AZJ10287.1
EMBL· GenBank· DDBJ
Genomic DNA
MH981824
EMBL· GenBank· DDBJ
AZJ13684.1
EMBL· GenBank· DDBJ
Genomic DNA
MG652751
EMBL· GenBank· DDBJ
QAT98036.1
EMBL· GenBank· DDBJ
Genomic DNA
MF437105
EMBL· GenBank· DDBJ
QBZ74601.1
EMBL· GenBank· DDBJ
Genomic DNA
MF437160
EMBL· GenBank· DDBJ
QBZ75316.1
EMBL· GenBank· DDBJ
Genomic DNA
MF437194
EMBL· GenBank· DDBJ
QBZ75758.1
EMBL· GenBank· DDBJ
Genomic DNA
MF437258
EMBL· GenBank· DDBJ
QBZ76590.1
EMBL· GenBank· DDBJ
Genomic DNA
MF437267
EMBL· GenBank· DDBJ
QBZ76707.1
EMBL· GenBank· DDBJ
Genomic DNA
MK134360
EMBL· GenBank· DDBJ
QGW54977.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849804
EMBL· GenBank· DDBJ
QKT25988.1
EMBL· GenBank· DDBJ
Genomic DNA
MW389270
EMBL· GenBank· DDBJ
QRC37185.1
EMBL· GenBank· DDBJ
Genomic DNA
MW291666
EMBL· GenBank· DDBJ
QVD40193.1
EMBL· GenBank· DDBJ
Genomic DNA
MN482524
EMBL· GenBank· DDBJ
QXE40396.1
EMBL· GenBank· DDBJ
Genomic DNA
MN628073
EMBL· GenBank· DDBJ
QXO91513.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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