Q6VA79 · Q6VA79_SARS

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell membrane
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functioncysteine-type endopeptidase activity
Molecular FunctionG-quadruplex RNA binding
Molecular Functionmethyltransferase activity
Molecular Functionomega peptidase activity
Molecular Functionsingle-stranded RNA binding
Molecular Functionzinc ion binding
Biological Processinduction by virus of host autophagy
Biological Processmethylation
Biological Processproteolysis
Biological Processsymbiont-mediated degradation of host mRNA
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host ISG15-protein conjugation
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral genome replication
Biological Processviral protein processing
Biological Processviral translational frameshifting
Biological Processvirus-mediated perturbation of host defense response

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Submitted names
    • Orf1a polyprotein

Organism names

  • Taxonomic identifier
  • Strain
    • CUHK-AG03
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Sarbecovirus > Severe acute respiratory syndrome coronavirus

Accessions

  • Primary accession
    Q6VA79

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane2206-2231Helical
Transmembrane2314-2333Helical
Transmembrane2340-2371Helical
Transmembrane2749-2768Helical
Transmembrane3020-3042Helical
Transmembrane3054-3078Helical
Transmembrane3115-3134Helical
Transmembrane3559-3582Helical
Transmembrane3588-3606Helical
Transmembrane3613-3634Helical
Transmembrane3660-3678Helical
Transmembrane3685-3701Helical
Transmembrane3721-3743Helical
Transmembrane3755-3774Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond2259↔2265

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain12-127CoV Nsp1 globular
Domain148-179BetaCoV Nsp1 C-terminal
Domain183-456CoV Nsp2 N-terminal
Domain458-688CoV Nsp2 middle
Domain690-818CoV Nsp2 C-terminal
Domain822-930Ubiquitin-like
Compositional bias972-997Acidic residues
Region972-1003Disordered
Domain1003-1169Macro
Region1175-1198Disordered
Domain1207-1335Macro
Domain1343-1470Macro
Domain1472-1538DPUP
Domain1542-1597Ubiquitin-like
Domain1611-1875Peptidase C16
Domain1888-1998Nucleic acid-binding
Domain2023-2132G2M
Domain2224-22943Ecto
Region2372-2462Y1
Domain2372-2740CoV Nsp3 Y
Region2376-2389ZF1
Region2422-2432ZF2
Region2463-2557Y2
Region2463-2740CoV-Y
Region2558-2639Y3
Region2640-2740Y4
Domain3142-3240Nsp4C
Domain3241-3546Peptidase C30
Domain3837-3919RdRp Nsp7 cofactor
Domain3920-4117RdRp Nsp8 cofactor
Domain4118-4230Nsp9 ssRNA-binding
Domain4231-4369ExoN/MTase coactivator

Sequence similarities

Belongs to the coronaviruses polyprotein 1ab family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    4,382
  • Mass (Da)
    486,373
  • Last updated
    2004-07-05 v1
  • Checksum
    E1F65D5FD5DFF828

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias972-997Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY345988
EMBL· GenBank· DDBJ
AAP94758.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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