Q6V586 · Q6V586_SARS
- ProteinORF1ab polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids7073 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
- ATP + H2O = ADP + H+ + phosphate
- uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 5992 | |||||
Sequence: D | ||||||
Active site | 5994 | |||||
Sequence: E | ||||||
Active site | 6093 | |||||
Sequence: E | ||||||
Active site | 6170 | |||||
Sequence: H | ||||||
Active site | 6175 | |||||
Sequence: D | ||||||
Binding site | 6233-6239 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: DIGNPKA | ||||||
Active site | 6663 | |||||
Sequence: H | ||||||
Active site | 6678 | |||||
Sequence: H | ||||||
Active site | 6718 | |||||
Sequence: K |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameORF1ab polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Sarbecovirus > Severe acute respiratory syndrome coronavirus
Accessions
- Primary accessionQ6V586
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 2206-2231 | Helical | ||||
Sequence: IAMWLLLLSICLGSLICVTAAFGVLL | ||||||
Transmembrane | 2314-2333 | Helical | ||||
Sequence: FFYLLGLSAIMQVFFGYFAS | ||||||
Transmembrane | 2340-2371 | Helical | ||||
Sequence: WLMWFIISIVQMAPVSAMVRMYIFFASFYYIW | ||||||
Transmembrane | 2749-2768 | Helical | ||||
Sequence: LMLKATLLCVLAALVCYIVM | ||||||
Transmembrane | 3020-3042 | Helical | ||||
Sequence: VSASVVAGGIIAILVTCAAYYFM | ||||||
Transmembrane | 3054-3078 | Helical | ||||
Sequence: VVAANALLFLMSFTILCLVPAYSFL | ||||||
Transmembrane | 3115-3134 | Helical | ||||
Sequence: FWITAIYVFCISLKHCHWFF | ||||||
Transmembrane | 3559-3582 | Helical | ||||
Sequence: WMLLTFLTSLLILVQSTQWSLFFF | ||||||
Transmembrane | 3588-3606 | Helical | ||||
Sequence: FLPFTLGIMAIAACAMLLV | ||||||
Transmembrane | 3613-3634 | Helical | ||||
Sequence: LCLFLLPSLATVAYFNMVYMPA | ||||||
Transmembrane | 3660-3678 | Helical | ||||
Sequence: VMYASALVLLILMTARTVY | ||||||
Transmembrane | 3685-3701 | Helical | ||||
Sequence: VWTLMNVITLVYKVYYG | ||||||
Transmembrane | 3721-3743 | Helical | ||||
Sequence: YSGVVTTIMFLARAIVFVCVEYY | ||||||
Transmembrane | 3755-3774 | Helical | ||||
Sequence: CIMLVYCFLGYCCCCYFGLF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 2259↔2265 | |||||
Sequence: CEGSFPC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-127 | CoV Nsp1 globular | ||||
Sequence: THVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGVLPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRNVLLRKNG | ||||||
Domain | 148-179 | BetaCoV Nsp1 C-terminal | ||||
Sequence: ELGTDPIEDYEQNWNTKHGSGALRELTRELNG | ||||||
Domain | 183-456 | CoV Nsp2 N-terminal | ||||
Sequence: TRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADIGSGHTGITGDNVETLNEDLLEILSR | ||||||
Domain | 458-688 | CoV Nsp2 middle | ||||
Sequence: RVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEM | ||||||
Domain | 690-818 | CoV Nsp2 C-terminal | ||||
Sequence: IDQVTIAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGG | ||||||
Domain | 822-930 | Ubiquitin-like | ||||
Sequence: KGVTFGEDTVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDE | ||||||
Compositional bias | 972-997 | Acidic residues | ||||
Sequence: RVEEEEEEDWLDDTTEQSEIEPEPEP | ||||||
Region | 972-1003 | Disordered | ||||
Sequence: RVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPV | ||||||
Domain | 1003-1169 | Macro | ||||
Sequence: VNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYL | ||||||
Region | 1175-1198 | Disordered | ||||
Sequence: RVEAPKQEEPPNTEDSKTEEKSVV | ||||||
Domain | 1207-1335 | Macro | ||||
Sequence: KIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSE | ||||||
Domain | 1343-1470 | Macro | ||||
Sequence: ILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSS | ||||||
Domain | 1472-1538 | DPUP | ||||
Sequence: TSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLS | ||||||
Domain | 1542-1597 | Ubiquitin-like | ||||
Sequence: VKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFV | ||||||
Domain | 1611-1875 | Peptidase C16 | ||||
Sequence: YYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDG | ||||||
Domain | 1888-1998 | Nucleic acid-binding | ||||
Sequence: PIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDT | ||||||
Domain | 2023-2132 | G2M | ||||
Sequence: PTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSN | ||||||
Domain | 2224-2294 | 3Ecto | ||||
Sequence: TAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLD | ||||||
Region | 2372-2462 | Y1 | ||||
Sequence: KSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTD | ||||||
Domain | 2372-2740 | CoV Nsp3 Y | ||||
Sequence: KSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGG | ||||||
Region | 2376-2389 | ZF1 | ||||
Sequence: HIMDGCTSSTCMMC | ||||||
Region | 2422-2432 | ZF2 | ||||
Sequence: CKTHNWNCLNC | ||||||
Region | 2463-2557 | Y2 | ||||
Sequence: QSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDV | ||||||
Region | 2463-2740 | CoV-Y | ||||
Sequence: QSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGG | ||||||
Region | 2558-2639 | Y3 | ||||
Sequence: GDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD | ||||||
Region | 2640-2740 | Y4 | ||||
Sequence: LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGG | ||||||
Domain | 3142-3240 | Nsp4C | ||||
Sequence: VMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ | ||||||
Domain | 3241-3546 | Peptidase C30 | ||||
Sequence: SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ | ||||||
Domain | 3837-3919 | RdRp Nsp7 cofactor | ||||
Sequence: SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQ | ||||||
Domain | 3920-4117 | RdRp Nsp8 cofactor | ||||
Sequence: AIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQ | ||||||
Domain | 4118-4230 | Nsp9 ssRNA-binding | ||||
Sequence: NNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ | ||||||
Domain | 4231-4369 | ExoN/MTase coactivator | ||||
Sequence: AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQ | ||||||
Domain | 4373-4630 | NiRAN | ||||
Sequence: ASTFLNGFAVLSAARLTPCGTGTSTDVVYRAFDIYNEKVAGFAKFLKTNCCRFQEKDEEGNLLDSYFVVKRHTMSNYQHEETIYNLVKDCPAVAVHDFFKFRVDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQSLLKTVQFCDAMRDAGIVGVLTLDNQDLNGNWYDFGDFVQVAPGCGVPIVDSYYSLLMPILTLTRALAAESHMDADL | ||||||
Domain | 4635-4733 | Nsp12 Interface | ||||
Sequence: IKWDLLKYDFTEERLCLFDRYFKYWDQTYHPNCINCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSS | ||||||
Domain | 4734-5301 | Nsp12 RNA-dependent RNA polymerase | ||||
Sequence: RLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVETPHLMGWDYPKCDRAMPNMLRIMASLVLARKHNTCCNLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDHEFVDEFYAYLRKHFSMMILSDDAVVCYNSNYAAQGLVASIKNFKAVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLIKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQ | ||||||
Domain | 4981-5143 | RdRp catalytic | ||||
Sequence: PHLMGWDYPKCDRAMPNMLRIMASLVLARKHNTCCNLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDHEFVDEFYAYLRKHFSMMILSDDAVVCYNSNYAAQG | ||||||
Domain | 5302-5385 | CV ZBD | ||||
Sequence: AVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLC | ||||||
Domain | 5558-5909 | +RNA virus helicase C-terminal | ||||
Sequence: NISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKIGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGL | ||||||
Domain | 5974-6189 | ExoN | ||||
Sequence: MFITREEAIRHVRAWIGFDVEGCHATRDAVGTNLPLQLGFSTGVNLVAVPTGYVDTENNTEFTRVNAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKGLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDKRATCFSTSSDTYACWNHSVGFDYVYNPFMIDVQQWGFTGNLQSNHDQHCQVHGNAHVASCDAIMTRCLAVHECFV | ||||||
Domain | 6198-6429 | N7-MTase | ||||
Sequence: YPIIGDELRVNSACRKVQHMVVKSALLADKFPVLHDIGNPKAIKCVPQAEVEWKFYDAQPCSDKAYKIEELFYSYATHHDKFTDGVCLFWNCNVDRYPANAIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFTNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRQYLDAYNMMISAGFSLWIYKQFDTYNLWNTFTRLQ | ||||||
Region | 6316-6330 | GpppA-binding | ||||
Sequence: CDGGSLYVNKHAFHT | ||||||
Domain | 6430-6490 | Nsp15 N-terminal oligomerization | ||||
Sequence: SLENVAYNVVNKGHFDGHAGEAPVSIINNAVYTKVDGIDVEIFENKTTLPVNVAFELWAKR | ||||||
Domain | 6491-6616 | AV-Nsp11N/CoV-Nsp15M | ||||
Sequence: NIKPVPEIKILNNLGVDIAANTVIWDYKREAPAHVSTIGVCTMTDIAKKPTESACSSLTVLFDGRVEGQVDLFRNARNGVLITEGSVKGLTPSKGPAQASVNGVTLIGESVKTQFNYFKKVDGIIQ | ||||||
Domain | 6633-6772 | NendoU | ||||
Sequence: KPRSQMETDFLELAMDEFIQRYKLEGYAFEHIVYGDFSHGQLGGLHLMIGLAKRSQDSPLKLEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVISKVVKVTIDYAEISFMLWCKDGHVETFYP | ||||||
Domain | 6777-7071 | Nidovirus-type SAM-dependent 2'-O-MTase | ||||
Sequence: SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPRTKHVTKENDSKEGFFTYLCGFIKQKLALGGSIAVKITEHSWNADLYKLMGHFSWWTAFVTNVNASSSEAFLIGANYLGKPKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSSDILV |
Sequence similarities
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length7,073
- Mass (Da)790,233
- Last updated2004-07-05 v1
- Checksum2E0FDF5E29738C7F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 972-997 | Acidic residues | ||||
Sequence: RVEEEEEEDWLDDTTEQSEIEPEPEP |
Keywords
- Coding sequence diversity