Q6V3X0 · PYRD_NAUCA
- ProteinDihydroorotate dehydrogenase (fumarate)
- GeneURA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids314 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
Catalytic activity
- (S)-dihydroorotate + fumarate = orotate + succinate
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 46 | substrate | |||
Binding site | 46-47 | FMN (UniProtKB | ChEBI) | |||
Binding site | 70-74 | substrate | |||
Binding site | 130 | FMN (UniProtKB | ChEBI) | |||
Binding site | 130 | substrate | |||
Active site | 132 | Nucleophile | |||
Active site | 133 | Nucleophile | |||
Binding site | 167 | FMN (UniProtKB | ChEBI) | |||
Binding site | 195 | FMN (UniProtKB | ChEBI) | |||
Binding site | 196-197 | substrate | |||
Binding site | 224 | FMN (UniProtKB | ChEBI) | |||
Binding site | 252-253 | FMN (UniProtKB | ChEBI) | |||
Binding site | 274-275 | FMN (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dihydroorotate dehydrogenase (fumarate) activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase (fumarate)
- EC number
- Short namesDHOD; DHODase; DHOdehase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Naumovozyma
Accessions
- Primary accessionQ6V3X0
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000148502 | 1-314 | Dihydroorotate dehydrogenase (fumarate) | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length314
- Mass (Da)34,862
- Last updated2004-07-05 v1
- MD5 ChecksumC10DD1647DD95F443649886D15EF1EA0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY352581 EMBL· GenBank· DDBJ | AAQ57200.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE576755 EMBL· GenBank· DDBJ | CCC69933.1 EMBL· GenBank· DDBJ | Genomic DNA |