Q6V3X0 · PYRD_NAUCA

Function

function

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway.

Features

Showing features for binding site, active site.

131420406080100120140160180200220240260280300
Type
IDPosition(s)Description
Binding site46substrate
Binding site46-47FMN (UniProtKB | ChEBI)
Binding site70-74substrate
Binding site130FMN (UniProtKB | ChEBI)
Binding site130substrate
Active site132Nucleophile
Active site133Nucleophile
Binding site167FMN (UniProtKB | ChEBI)
Binding site195FMN (UniProtKB | ChEBI)
Binding site196-197substrate
Binding site224FMN (UniProtKB | ChEBI)
Binding site252-253FMN (UniProtKB | ChEBI)
Binding site274-275FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondihydroorotate dehydrogenase (fumarate) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase (fumarate)
  • EC number
  • Short names
    DHOD; DHODase; DHOdehase
  • Alternative names
    • Dihydroorotate oxidase

Gene names

    • Name
      URA1
    • Ordered locus names
      NCAS_0D03520

Organism names

Accessions

  • Primary accession
    Q6V3X0
  • Secondary accessions
    • G0VEE2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001485021-314Dihydroorotate dehydrogenase (fumarate)

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    314
  • Mass (Da)
    34,862
  • Last updated
    2004-07-05 v1
  • MD5 Checksum
    C10DD1647DD95F443649886D15EF1EA0
MPASLTTKFLNQTYENPLMNASGVHCMTTKELDELAASRAGAFITKSSTTLERAGNPEPRYVSVPLGSINSMGLPNQGIDYYLEYVLERQRTHPNEPAIFFSVAGMSIDENINMLRKIQDSEFHGITELNLSCPNVPGKPQVAYDFDLTKEILDKVFQFFKKPLGIKLPPYFDFAHFDIMAGILNQYPLAYVNSINSVGNGLYIDVDKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLNPSIKIVGTGGIRTGKDVFEHLLCGASMVQIGTELVKEGVPIFERLERELKEVMDKKGYTTIEEFRGKLNSL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY352581
EMBL· GenBank· DDBJ
AAQ57200.1
EMBL· GenBank· DDBJ
Genomic DNA
HE576755
EMBL· GenBank· DDBJ
CCC69933.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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