Q6UXN9 · WDR82_HUMAN
- ProteinWD repeat-containing protein 82
- GeneWDR82
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids313 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Regulatory component of the SET1/COMPASS complex implicated in the tethering of this complex to transcriptional start sites of active genes (PubMed:17998332, PubMed:18838538, PubMed:20516061).
Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332, PubMed:18838538).
Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061).
Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806).
The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452).
Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332, PubMed:18838538).
Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061).
Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806).
The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | histone methyltransferase complex | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Cellular Component | PTW/PP1 phosphatase complex | |
Cellular Component | Set1C/COMPASS complex | |
Molecular Function | chromatin binding | |
Biological Process | DNA-templated transcription termination | |
Biological Process | lncRNA catabolic process | |
Biological Process | negative regulation of DNA-templated transcription, elongation | |
Biological Process | negative regulation of lncRNA transcription | |
Biological Process | nuclear RNA surveillance |
Keywords
- Biological process
Enzyme and pathway databases
A complex of WDR82 with ZC3H4 suppresses extragenic transcription in mammalian cells.
Names & Taxonomy
Protein names
- Recommended nameWD repeat-containing protein 82
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6UXN9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Associates with chromatin (PubMed:20516061).
Recruited at sites of high RNA polymerase II occupancy (By similarity).
Recruited at sites of high RNA polymerase II occupancy (By similarity).
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 183 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000279685 | 1-313 | UniProt | WD repeat-containing protein 82 | |||
Sequence: MKLTDSVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD | |||||||
Modified residue (large scale data) | 6 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 10 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Component of the SET1/COMPASS complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (PubMed:16253997, PubMed:17355966, PubMed:17998332, PubMed:18838538).
Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC (PubMed:20516061).
Associated with multiple protein complexes including an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex (PubMed:20516061).
Interacts with SETD1B (via N-terminal region); the interaction is direct (PubMed:17998332, PubMed:37030068).
Interacts with SETD1A (via N-terminal region); the interaction is direct (PubMed:17998332, PubMed:37030068).
Interacts with CUL4B (PubMed:17041588).
Interacts with RBBP5 (PubMed:18838538).
Interacts with POLR2B (PubMed:17998332).
Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332).
Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad (PubMed:17998332).
SETD1A enhances its interaction with POLR2A (PubMed:17998332).
Interacts with PPP1R10/PNUTS (PubMed:20516061).
Interacts with PPP1CA in the presence of PPP1R10/PNUTS (PubMed:20516061).
Interacts with ZC3H4; interaction is independent of the SET1 complex and promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33913806).
Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC (PubMed:20516061).
Associated with multiple protein complexes including an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex (PubMed:20516061).
Interacts with SETD1B (via N-terminal region); the interaction is direct (PubMed:17998332, PubMed:37030068).
Interacts with SETD1A (via N-terminal region); the interaction is direct (PubMed:17998332, PubMed:37030068).
Interacts with CUL4B (PubMed:17041588).
Interacts with RBBP5 (PubMed:18838538).
Interacts with POLR2B (PubMed:17998332).
Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332).
Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad (PubMed:17998332).
SETD1A enhances its interaction with POLR2A (PubMed:17998332).
Interacts with PPP1R10/PNUTS (PubMed:20516061).
Interacts with PPP1CA in the presence of PPP1R10/PNUTS (PubMed:20516061).
Interacts with ZC3H4; interaction is independent of the SET1 complex and promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33913806).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 19-58 | WD 1 | ||||
Sequence: ENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRT | ||||||
Repeat | 105-144 | WD 2 | ||||
Sequence: GHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGL | ||||||
Repeat | 146-184 | WD 3 | ||||
Sequence: HLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPF | ||||||
Repeat | 192-231 | WD 4 | ||||
Sequence: DRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHT | ||||||
Repeat | 236-276 | WD 5 | ||||
Sequence: ANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAV | ||||||
Repeat | 280-313 | WD 6 | ||||
Sequence: KHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD |
Sequence similarities
Belongs to the WD repeat SWD2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length313
- Mass (Da)35,079
- Last updated2004-07-05 v1
- ChecksumFD3505A9B89863A0
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
C9JBU3 | C9JBU3_HUMAN | WDR82 | 199 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY358264 EMBL· GenBank· DDBJ | AAQ88631.1 EMBL· GenBank· DDBJ | mRNA | ||
AK074290 EMBL· GenBank· DDBJ | BAB85039.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK291380 EMBL· GenBank· DDBJ | BAF84069.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471055 EMBL· GenBank· DDBJ | EAW65202.1 EMBL· GenBank· DDBJ | Genomic DNA |