Q6UX27 · VSTM1_HUMAN
- ProteinV-set and transmembrane domain-containing protein 1
- GeneVSTM1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids236 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Isoform 2
Isoform 1
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | plasma membrane | |
Molecular Function | cytokine activity | |
Biological Process | immune response-regulating signaling pathway | |
Biological Process | immune system process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameV-set and transmembrane domain-containing protein 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6UX27
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 17-135 | Extracellular | ||||
Sequence: YEDEKKNEKPPKPSLHAWPSSVVEAESNVTLKCQAHSQNVTFVLRKVNDSGYKQEQSSAENEAEFPFTDLKPKDAGRYFCAYKTTASHEWSESSEHLQLVVTDKHDELEAPSMKTDTRT | ||||||
Transmembrane | 136-156 | Helical | ||||
Sequence: IFVAIFSCISILLLFLSVFII | ||||||
Topological domain | 157-236 | Cytoplasmic | ||||
Sequence: YRCSQHSSSSEESTKRTSHSKLPEQEAAEADLSNMERVSLSTADPQGVTYAELSTSALSEAASDTTQEPPGSHEYAALKV |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_030034 | 163 | in dbSNP:rs2433724 | |||
Sequence: S → G |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 507 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-16 | |||||
Sequence: MTAEFLSLLCLGLCLG | ||||||
Chain | PRO_0000272269 | 17-236 | V-set and transmembrane domain-containing protein 1 | |||
Sequence: YEDEKKNEKPPKPSLHAWPSSVVEAESNVTLKCQAHSQNVTFVLRKVNDSGYKQEQSSAENEAEFPFTDLKPKDAGRYFCAYKTTASHEWSESSEHLQLVVTDKHDELEAPSMKTDTRTIFVAIFSCISILLLFLSVFIIYRCSQHSSSSEESTKRTSHSKLPEQEAAEADLSNMERVSLSTADPQGVTYAELSTSALSEAASDTTQEPPGSHEYAALKV | ||||||
Glycosylation | 44 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 49↔96 | |||||
Sequence: CQAHSQNVTFVLRKVNDSGYKQEQSSAENEAEFPFTDLKPKDAGRYFC | ||||||
Glycosylation | 55 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 27-114 | Ig-like V-type | ||||
Sequence: PKPSLHAWPSSVVEAESNVTLKCQAHSQNVTFVLRKVNDSGYKQEQSSAENEAEFPFTDLKPKDAGRYFCAYKTTASHEWSESSEHLQ | ||||||
Region | 166-200 | Disordered | ||||
Sequence: SEESTKRTSHSKLPEQEAAEADLSNMERVSLSTAD | ||||||
Compositional bias | 168-182 | Basic and acidic residues | ||||
Sequence: ESTKRTSHSKLPEQE | ||||||
Motif | 204-209 | ITIM motif 1 | ||||
Sequence: VTYAEL | ||||||
Region | 215-236 | Disordered | ||||
Sequence: SEAASDTTQEPPGSHEYAALKV | ||||||
Motif | 229-234 | ITIM motif 2 | ||||
Sequence: HEYAAL |
Domain
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 3 isoforms produced by Alternative splicing.
Q6UX27-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length236
- Mass (Da)26,109
- Last updated2010-05-18 v2
- Checksum508E7881ADF6E1A5
Q6UX27-2
- Name2
- SynonymsVSTM1-v2
- NoteMainly detected in immune tissues and cells.
- Differences from canonical
- 132-163: DTRTIFVAIFSCISILLLFLSVFIIYRCSQHS → G
Q6UX27-3
- Name3
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8Y636 | A0A2R8Y636_HUMAN | VSTM1 | 229 | ||
D2DJS5 | D2DJS5_HUMAN | VSTM1 | 116 | ||
G8JLN4 | G8JLN4_HUMAN | VSTM1 | 143 | ||
A0A0G2JPS7 | A0A0G2JPS7_HUMAN | VSTM1 | 148 | ||
H7C340 | H7C340_HUMAN | VSTM1 | 126 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_022381 | 132-163 | in isoform 2 | |||
Sequence: DTRTIFVAIFSCISILLLFLSVFIIYRCSQHS → G | ||||||
Alternative sequence | VSP_022382 | 164-174 | in isoform 3 | |||
Sequence: SSSEESTKRTS → ELRERKGREGE | ||||||
Compositional bias | 168-182 | Basic and acidic residues | ||||
Sequence: ESTKRTSHSKLPEQE | ||||||
Alternative sequence | VSP_022383 | 175-236 | in isoform 3 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ584316 EMBL· GenBank· DDBJ | ACU00108.1 EMBL· GenBank· DDBJ | mRNA | ||
FJ584317 EMBL· GenBank· DDBJ | ACU00109.1 EMBL· GenBank· DDBJ | mRNA | ||
FJ584318 EMBL· GenBank· DDBJ | ACU00110.1 EMBL· GenBank· DDBJ | mRNA | ||
FN398145 EMBL· GenBank· DDBJ | CAZ61324.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ479397 EMBL· GenBank· DDBJ | ABF19807.1 EMBL· GenBank· DDBJ | mRNA | ||
AY358542 EMBL· GenBank· DDBJ | AAQ88906.1 EMBL· GenBank· DDBJ | mRNA | ||
AC012314 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC100942 EMBL· GenBank· DDBJ | AAI00943.1 EMBL· GenBank· DDBJ | mRNA | ||
BC100943 EMBL· GenBank· DDBJ | AAI00944.1 EMBL· GenBank· DDBJ | mRNA |