Q6UX27 · VSTM1_HUMAN

  • Protein
    V-set and transmembrane domain-containing protein 1
  • Gene
    VSTM1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Isoform 2

Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).

Isoform 1

Inhibitory immune receptor involved in the regulation of phagocytes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentplasma membrane
Molecular Functioncytokine activity
Biological Processimmune response-regulating signaling pathway
Biological Processimmune system process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    V-set and transmembrane domain-containing protein 1
  • Alternative names
    • Signal inhibitory receptor on leukocytes-1 (SIRL-1)

Gene names

    • Name
      VSTM1
    • ORF names
      UNQ3033/PRO9835

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6UX27
  • Secondary accessions
    • B6A8C6
    • D2DJS3
    • D2DJS4
    • Q496B6
    • Q496B7

Proteomes

Organism-specific databases

Subcellular Location

Isoform 1

Membrane
; Single-pass membrane protein

Isoform 2

Secreted

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain17-135Extracellular
Transmembrane136-156Helical
Topological domain157-236Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_030034163in dbSNP:rs2433724

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 507 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_000027226917-236V-set and transmembrane domain-containing protein 1
Glycosylation44N-linked (GlcNAc...) asparagine
Disulfide bond49↔96
Glycosylation55N-linked (GlcNAc...) asparagine

Post-translational modification

Isoform 2 is N-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q6UX27-3ADGRG3 Q86Y343EBI-12190699, EBI-17979264
BINARY Q6UX27-3APH1B Q8WW433EBI-12190699, EBI-2606497
BINARY Q6UX27-3AQP6 Q135203EBI-12190699, EBI-13059134
BINARY Q6UX27-3ARL13B Q3SXY83EBI-12190699, EBI-11343438
BINARY Q6UX27-3CD53 P193973EBI-12190699, EBI-6657396
BINARY Q6UX27-3CLDN7 O954713EBI-12190699, EBI-740744
BINARY Q6UX27-3CLDN9 O954843EBI-12190699, EBI-18341636
BINARY Q6UX27-3CLEC10A Q8IUN93EBI-12190699, EBI-2873246
BINARY Q6UX27-3COQ9 O752083EBI-12190699, EBI-724524
BINARY Q6UX27-3ERGIC3 Q9Y2823EBI-12190699, EBI-781551
BINARY Q6UX27-3FATE1 Q969F03EBI-12190699, EBI-743099
BINARY Q6UX27-3FBXO2 Q9UK223EBI-12190699, EBI-4287196
BINARY Q6UX27-3FCGR1A P123143EBI-12190699, EBI-2869867
BINARY Q6UX27-3FNDC9 Q8TBE33EBI-12190699, EBI-12142257
BINARY Q6UX27-3GJB5 O953773EBI-12190699, EBI-3909454
BINARY Q6UX27-3GOLM1 Q8NBJ43EBI-12190699, EBI-712073
BINARY Q6UX27-3GPX8 Q8TED13EBI-12190699, EBI-11721746
BINARY Q6UX27-3HCST Q9UBK53EBI-12190699, EBI-2801937
BINARY Q6UX27-3KCNJ6 P480513EBI-12190699, EBI-12017638
BINARY Q6UX27-3LAMP1 P112793EBI-12190699, EBI-2805407
BINARY Q6UX27-3LRRC4C Q9HCJ23EBI-12190699, EBI-3925442
BINARY Q6UX27-3MANSC1 Q9H8J53EBI-12190699, EBI-2830042
BINARY Q6UX27-3MFSD4B Q5TF393EBI-12190699, EBI-11922631
BINARY Q6UX27-3MRM1 Q6IN843EBI-12190699, EBI-5454865
BINARY Q6UX27-3PLPP2 O436883EBI-12190699, EBI-722017
BINARY Q6UX27-3STMN4 Q9H169-23EBI-12190699, EBI-20117546
BINARY Q6UX27-3TMEM248 Q9NWD83EBI-12190699, EBI-10314986

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, motif.

TypeIDPosition(s)Description
Domain27-114Ig-like V-type
Region166-200Disordered
Compositional bias168-182Basic and acidic residues
Motif204-209ITIM motif 1
Region215-236Disordered
Motif229-234ITIM motif 2

Domain

Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Both motives are required for full inhibition of FCER1A-mediated degranulation.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative splicing.

Q6UX27-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    236
  • Mass (Da)
    26,109
  • Last updated
    2010-05-18 v2
  • Checksum
    508E7881ADF6E1A5
MTAEFLSLLCLGLCLGYEDEKKNEKPPKPSLHAWPSSVVEAESNVTLKCQAHSQNVTFVLRKVNDSGYKQEQSSAENEAEFPFTDLKPKDAGRYFCAYKTTASHEWSESSEHLQLVVTDKHDELEAPSMKTDTRTIFVAIFSCISILLLFLSVFIIYRCSQHSSSSEESTKRTSHSKLPEQEAAEADLSNMERVSLSTADPQGVTYAELSTSALSEAASDTTQEPPGSHEYAALKV

Q6UX27-2

  • Name
    2
  • Synonyms
    VSTM1-v2
  • Note
    Mainly detected in immune tissues and cells.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 132-163: DTRTIFVAIFSCISILLLFLSVFIIYRCSQHS → G

Q6UX27-3

  • Name
    3
  • Note
    May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8Y636A0A2R8Y636_HUMANVSTM1229
D2DJS5D2DJS5_HUMANVSTM1116
G8JLN4G8JLN4_HUMANVSTM1143
A0A0G2JPS7A0A0G2JPS7_HUMANVSTM1148
H7C340H7C340_HUMANVSTM1126

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_022381132-163in isoform 2
Alternative sequenceVSP_022382164-174in isoform 3
Compositional bias168-182Basic and acidic residues
Alternative sequenceVSP_022383175-236in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ584316
EMBL· GenBank· DDBJ
ACU00108.1
EMBL· GenBank· DDBJ
mRNA
FJ584317
EMBL· GenBank· DDBJ
ACU00109.1
EMBL· GenBank· DDBJ
mRNA
FJ584318
EMBL· GenBank· DDBJ
ACU00110.1
EMBL· GenBank· DDBJ
mRNA
FN398145
EMBL· GenBank· DDBJ
CAZ61324.1
EMBL· GenBank· DDBJ
mRNA
DQ479397
EMBL· GenBank· DDBJ
ABF19807.1
EMBL· GenBank· DDBJ
mRNA
AY358542
EMBL· GenBank· DDBJ
AAQ88906.1
EMBL· GenBank· DDBJ
mRNA
AC012314
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC100942
EMBL· GenBank· DDBJ
AAI00943.1
EMBL· GenBank· DDBJ
mRNA
BC100943
EMBL· GenBank· DDBJ
AAI00944.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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