Q6UWW8 · EST3_HUMAN
- ProteinCarboxylesterase 3
- GeneCES3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids571 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Catalytic activity
- a carboxylic ester + H2O = a carboxylate + an alcohol + H+
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
137 μM | 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin | |||||
460 μM | 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin |
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 229 | Acyl-ester intermediate | ||||
Sequence: S | ||||||
Active site | 347 | Charge relay system | ||||
Sequence: E | ||||||
Active site | 460 | Charge relay system | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum lumen | |
Cellular Component | extracellular exosome | |
Molecular Function | carboxylesterase activity | |
Molecular Function | carboxylic ester hydrolase activity | |
Biological Process | low-density lipoprotein particle clearance | |
Biological Process | xenobiotic metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCarboxylesterase 3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6UWW8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_060699 | 129 | in dbSNP:rs61745806 | |||
Sequence: V → I | ||||||
Natural variant | VAR_060700 | 151 | in dbSNP:rs71647891 | |||
Sequence: A → T | ||||||
Natural variant | VAR_060701 | 160 | in dbSNP:rs71647892 | |||
Sequence: Y → H | ||||||
Natural variant | VAR_060702 | 191 | in dbSNP:rs61742964 | |||
Sequence: E → K | ||||||
Natural variant | VAR_060703 | 213 | in dbSNP:rs71647894 | |||
Sequence: I → N | ||||||
Natural variant | VAR_060704 | 367 | in dbSNP:rs61743167 | |||
Sequence: R → W | ||||||
Natural variant | VAR_060705 | 523 | in dbSNP:rs71649615 | |||
Sequence: A → V | ||||||
Natural variant | VAR_060706 | 555 | in dbSNP:rs8059252 | |||
Sequence: I → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 669 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MERAVRVESGVLVGVVCLLLACPATA | ||||||
Chain | PRO_0000305191 | 27-571 | Carboxylesterase 3 | |||
Sequence: TGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKFREAWMQFWSETLPSKIQQWHQKQKNRKAQEDL | ||||||
Disulfide bond | 97↔124 | |||||
Sequence: CLQDVESMNSSRFVLNGKQQIFSVSEDC | ||||||
Glycosylation | 105 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 281↔292 | |||||
Sequence: CSSSSPAEMVQC |
Post-translational modification
N-glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in liver, colon and small intestine.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 568-571 | Prevents secretion from ER | ||||
Sequence: QEDL |
Sequence similarities
Belongs to the type-B carboxylesterase/lipase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q6UWW8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length571
- Mass (Da)62,282
- Last updated2004-07-05 v1
- ChecksumF2200968FDE072D2
Q6UWW8-2
- Name2
- Differences from canonical
- 1-361: Missing
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H3BUA3 | H3BUA3_HUMAN | CES3 | 379 | ||
H3BRE5 | H3BRE5_HUMAN | CES3 | 40 | ||
A0A0C4DFY7 | A0A0C4DFY7_HUMAN | CES3 | 568 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_044994 | 1-361 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 372 | in Ref. 3; BAB15123 | ||||
Sequence: A → S | ||||||
Sequence conflict | 481-483 | in Ref. 7; AAH53670 | ||||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY358609 EMBL· GenBank· DDBJ | AAQ88972.1 EMBL· GenBank· DDBJ | mRNA | ||
AK025389 EMBL· GenBank· DDBJ | BAB15123.1 EMBL· GenBank· DDBJ | mRNA | ||
EU595874 EMBL· GenBank· DDBJ | ACD11491.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC009084 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471092 EMBL· GenBank· DDBJ | EAW83060.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC053670 EMBL· GenBank· DDBJ | AAH53670.1 EMBL· GenBank· DDBJ | mRNA |