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Q6UUU7 · Q6UUU7_ECOLX

  • Protein
    Dihydropteroate synthase
  • Gene
    sulII
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondihydropteroate synthase activity
Molecular Functionmetal ion binding
Biological Processfolic acid biosynthetic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydropteroate synthase
  • EC number
  • Short names
    DHPS
  • Alternative names
    • Dihydropteroate pyrophosphorylase

Gene names

    • Name
      sulII
    • Synonyms
      folP
      , folP2_1
      , sul2
    • ORF names
      AWP47_03040
      , AWP47_04015
      , AWP47_17655
      , BANRA_05498
      , BANRA_05855
      , BB545_24545
      , BG944_002970
      , BG944_005726
      , BK300_23305
      , BK383_26880
      , BTQ06_26830
      , BvCmsSIP010_01790
      , CCS08_28435
      , CR538_26935
      , CTR35_003059
      , CTR35_005434
      , CWS33_26570
      , DD762_27725
      , DL968_17025
      , DL968_27755
      , DNQ45_00095
      , DNX30_28845
      , DNX30_30475
      , DS732_29800
      , E2865_05943
      , E4K51_26285
      , E5H86_28175
      , E5H86_30815
      , E6D34_23475
      , E6D34_29495
      , EAI46_15570
      , EIZ93_20315
      , F9461_27740
      , F9461_28500
      , F9B07_28050
      , FGAF1253_47140
      , FGAF848_39100
      , FGAF862_44470
      , FKO60_21470
      , FPS11_18295
      , FPS11_29965
      , G3V95_26100
      , G3W53_19905
      , G5603_20495
      , GKF66_22245
      , GP965_25555
      , GQE86_24065
      , GQM21_26255
      , GRC73_24005
      , GRW24_04580
      , HEP34_005172
      , HEP34_005460
      , HHH44_005046
      , HHH44_005296
      , HIE29_003729
      , HIE29_005536
      , HJQ60_005280
      , HJQ60_005812
      , HLZ50_23910
      , HLZ50_26560
      , HMV95_25580
      , HMV95_26465
      , HVW04_25370
      , J0541_005274
      , J0541_005908
      , NOI85_28360
      , NY836_16640
      , OGM49_26720
      , p369_00091
      , P6223_005493
      , P6223_006049
      , peH4H_0048
      , pESCR_00108
      , pPG010208_49
      , pQ1.1
      , pRAx_0066
      , pSCEC2_019
      , QDW62_26805
      , RCS92_PI0001
      , SAMEA3472056_02421
      , WR15_22880

Encoded on

  • Plasmid RCS92_pI
  • Plasmid p14EC029b
  • Plasmid p14ec029b
  • Plasmid p369
  • Plasmid p39R861-4
  • Plasmid p6148
  • Plasmid p9123
  • Plasmid pBK32533
  • Plasmid pCA08
  • Plasmid pCERC1
  • Plasmid pE2865-3
  • Plasmid pEC299-4
  • Plasmid pESBL-305
  • Plasmid pESCR
  • Plasmid pF1253-2
  • Plasmid pF862-1
  • Plasmid pH2291-112
  • Plasmid pHV295
  • Plasmid pJIE250
  • Plasmid pM5A24P
  • Plasmid pPG010208
  • Plasmid pQ1-1
  • Plasmid pRAx
  • Plasmid pRHB07-C04_3
  • Plasmid pS7-S3K40-2
  • Plasmid pSCEC2
  • Plasmid pWJ1
  • Plasmid pYDC637
  • Plasmid pe2865-3 dna
  • Plasmid peH4H
  • Plasmid prhb07-c04_3
  • Plasmid rcs92_pi
  • Plasmid unnamed2
  • Plasmid unnamed3

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 347
    • 369
    • 570
    • 574
    • 3512
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    Q6UUU7

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-259Pterin-binding

Sequence similarities

Belongs to the DHPS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    271
  • Mass (Da)
    28,470
  • Last updated
    2005-05-10 v1
  • MD5 Checksum
    11A14165B9F48E49CB97408B9E6B17F1
MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVSSDTEIARIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAALTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAAGGADFIRTHEPRPLRDGLAVLAALKETARIR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY360321
EMBL· GenBank· DDBJ
AAQ96758.1
EMBL· GenBank· DDBJ
Genomic DNA
EU580136
EMBL· GenBank· DDBJ
ACF05513.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ705806
EMBL· GenBank· DDBJ
ACN66882.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ621586
EMBL· GenBank· DDBJ
ACQ77658.1
EMBL· GenBank· DDBJ
Genomic DNA
HM371192
EMBL· GenBank· DDBJ
ADJ51134.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ023861
EMBL· GenBank· DDBJ
ADM62442.1
EMBL· GenBank· DDBJ
Genomic DNA
JN012467
EMBL· GenBank· DDBJ
AEO37484.1
EMBL· GenBank· DDBJ
Genomic DNA
EU418932
EMBL· GenBank· DDBJ
AER36577.1
EMBL· GenBank· DDBJ
Genomic DNA
JX238460
EMBL· GenBank· DDBJ
AGI05147.1
EMBL· GenBank· DDBJ
Genomic DNA
KF152885
EMBL· GenBank· DDBJ
AGW01044.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ484629
EMBL· GenBank· DDBJ
AIF77882.1
EMBL· GenBank· DDBJ
Genomic DNA
CP008737
EMBL· GenBank· DDBJ
AIG72717.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ868771
EMBL· GenBank· DDBJ
AIK66786.1
EMBL· GenBank· DDBJ
Genomic DNA
KP056256
EMBL· GenBank· DDBJ
AIY22894.1
EMBL· GenBank· DDBJ
Genomic DNA
KM377240
EMBL· GenBank· DDBJ
AJM91111.1
EMBL· GenBank· DDBJ
Genomic DNA
KP276584
EMBL· GenBank· DDBJ
AJT60270.1
EMBL· GenBank· DDBJ
Genomic DNA
KP345882
EMBL· GenBank· DDBJ
AKA87091.1
EMBL· GenBank· DDBJ
Genomic DNA
CP009233
EMBL· GenBank· DDBJ
AKD26863.1
EMBL· GenBank· DDBJ
Genomic DNA
KR494248
EMBL· GenBank· DDBJ
AKN35614.1
EMBL· GenBank· DDBJ
Genomic DNA
KT779550
EMBL· GenBank· DDBJ
ALG88139.1
EMBL· GenBank· DDBJ
Genomic DNA
KY924928
EMBL· GenBank· DDBJ
ASF81913.1
EMBL· GenBank· DDBJ
Genomic DNA
CP024143
EMBL· GenBank· DDBJ
AUK03928.1
EMBL· GenBank· DDBJ
Genomic DNA
CP031549
EMBL· GenBank· DDBJ
AXO10344.1
EMBL· GenBank· DDBJ
Genomic DNA
AP018811
EMBL· GenBank· DDBJ
BBF62998.1
EMBL· GenBank· DDBJ
Genomic DNA
CAUZHL010000005
EMBL· GenBank· DDBJ
CAK1213935.1
EMBL· GenBank· DDBJ
Genomic DNA
OY757098
EMBL· GenBank· DDBJ
CAK1258284.1
EMBL· GenBank· DDBJ
Genomic DNA
OY757133
EMBL· GenBank· DDBJ
CAK1261757.1
EMBL· GenBank· DDBJ
Genomic DNA
AASFMQ010000027
EMBL· GenBank· DDBJ
EFB3616844.1
EMBL· GenBank· DDBJ
Genomic DNA
AASFMQ010000159
EMBL· GenBank· DDBJ
EFB3619008.1
EMBL· GenBank· DDBJ
Genomic DNA
AASEPP010000112
EMBL· GenBank· DDBJ
EFC2249544.1
EMBL· GenBank· DDBJ
Genomic DNA
AASEPP010000286
EMBL· GenBank· DDBJ
EFC2250025.1
EMBL· GenBank· DDBJ
Genomic DNA
AASHPR010000027
EMBL· GenBank· DDBJ
EFC3525888.1
EMBL· GenBank· DDBJ
Genomic DNA
AASHPR010000239
EMBL· GenBank· DDBJ
EFC3528083.1
EMBL· GenBank· DDBJ
Genomic DNA
AASEBA010000071
EMBL· GenBank· DDBJ
EFC9752155.1
EMBL· GenBank· DDBJ
Genomic DNA
AASEBA010000311
EMBL· GenBank· DDBJ
EFC9753211.1
EMBL· GenBank· DDBJ
Genomic DNA
AASVQO010000066
EMBL· GenBank· DDBJ
EFH3676890.1
EMBL· GenBank· DDBJ
Genomic DNA
AASVQO010000128
EMBL· GenBank· DDBJ
EFH3677008.1
EMBL· GenBank· DDBJ
Genomic DNA
AASXRC010000014
EMBL· GenBank· DDBJ
EFI0213782.1
EMBL· GenBank· DDBJ
Genomic DNA
AASXRC010000147
EMBL· GenBank· DDBJ
EFI0216363.1
EMBL· GenBank· DDBJ
Genomic DNA
AATJYL010000105
EMBL· GenBank· DDBJ
EFM1448699.1
EMBL· GenBank· DDBJ
Genomic DNA
AATJYL010000178
EMBL· GenBank· DDBJ
EFM1448939.1
EMBL· GenBank· DDBJ
Genomic DNA
AAVTXU010000071
EMBL· GenBank· DDBJ
EGE1989295.1
EMBL· GenBank· DDBJ
Genomic DNA
AAVTXU010000347
EMBL· GenBank· DDBJ
EGE1991219.1
EMBL· GenBank· DDBJ
Genomic DNA
ABLFQU030000112
EMBL· GenBank· DDBJ
EMM0028780.1
EMBL· GenBank· DDBJ
Genomic DNA
ABLFQU030000246
EMBL· GenBank· DDBJ
EMM0029271.1
EMBL· GenBank· DDBJ
Genomic DNA
BGIE01000028
EMBL· GenBank· DDBJ
GDV20125.1
EMBL· GenBank· DDBJ
Genomic DNA
DABALL010000094
EMBL· GenBank· DDBJ
HAH1421554.1
EMBL· GenBank· DDBJ
Genomic DNA
DABALL010000173
EMBL· GenBank· DDBJ
HAH1421784.1
EMBL· GenBank· DDBJ
Genomic DNA
DABBJX010000064
EMBL· GenBank· DDBJ
HAH4527012.1
EMBL· GenBank· DDBJ
Genomic DNA
DABCJL010000008
EMBL· GenBank· DDBJ
HAH7770257.1
EMBL· GenBank· DDBJ
Genomic DNA
DABCJL010000055
EMBL· GenBank· DDBJ
HAH7771929.1
EMBL· GenBank· DDBJ
Genomic DNA
DABERK010000054
EMBL· GenBank· DDBJ
HAI5335158.1
EMBL· GenBank· DDBJ
Genomic DNA
DABERK010000170
EMBL· GenBank· DDBJ
HAI5335618.1
EMBL· GenBank· DDBJ
Genomic DNA
DABGKZ010000067
EMBL· GenBank· DDBJ
HAJ5153044.1
EMBL· GenBank· DDBJ
Genomic DNA
DABGKZ010000185
EMBL· GenBank· DDBJ
HAJ5153513.1
EMBL· GenBank· DDBJ
Genomic DNA
DABHXT010000147
EMBL· GenBank· DDBJ
HAJ5961542.1
EMBL· GenBank· DDBJ
Genomic DNA
DABHXT010000181
EMBL· GenBank· DDBJ
HAJ5961707.1
EMBL· GenBank· DDBJ
Genomic DNA
DADUEU010000070
EMBL· GenBank· DDBJ
HBB1576219.1
EMBL· GenBank· DDBJ
Genomic DNA
DADUEU010000235
EMBL· GenBank· DDBJ
HBB1576777.1
EMBL· GenBank· DDBJ
Genomic DNA
LGZN01000079
EMBL· GenBank· DDBJ
KNF63730.1
EMBL· GenBank· DDBJ
Genomic DNA
JANWOR010000475
EMBL· GenBank· DDBJ
MDA4178993.1
EMBL· GenBank· DDBJ
Genomic DNA
JANFIP010000131
EMBL· GenBank· DDBJ
MDS0708313.1
EMBL· GenBank· DDBJ
Genomic DNA
RTJF01000097
EMBL· GenBank· DDBJ
MJL96607.1
EMBL· GenBank· DDBJ
Genomic DNA
RTJF01000147
EMBL· GenBank· DDBJ
MJL96910.1
EMBL· GenBank· DDBJ
Genomic DNA
RYCF01000100
EMBL· GenBank· DDBJ
MQK26602.1
EMBL· GenBank· DDBJ
Genomic DNA
SQQU01000102
EMBL· GenBank· DDBJ
MQS33532.1
EMBL· GenBank· DDBJ
Genomic DNA
WKUE01000051
EMBL· GenBank· DDBJ
MSI71472.1
EMBL· GenBank· DDBJ
Genomic DNA
WCEW01000096
EMBL· GenBank· DDBJ
MTE92534.1
EMBL· GenBank· DDBJ
Genomic DNA
WSXK01000110
EMBL· GenBank· DDBJ
MWF98079.1
EMBL· GenBank· DDBJ
Genomic DNA
WTML01000251
EMBL· GenBank· DDBJ
MWL00604.1
EMBL· GenBank· DDBJ
Genomic DNA
WTRC01000742
EMBL· GenBank· DDBJ
MWT24247.1
EMBL· GenBank· DDBJ
Genomic DNA
WUIG01000033
EMBL· GenBank· DDBJ
MXJ07764.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAGYI010000168
EMBL· GenBank· DDBJ
NEM88862.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAGYP010000032
EMBL· GenBank· DDBJ
NEN72358.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAJRI010000020
EMBL· GenBank· DDBJ
NGE90535.1
EMBL· GenBank· DDBJ
Genomic DNA
MOHC01000049
EMBL· GenBank· DDBJ
OJN35008.1
EMBL· GenBank· DDBJ
Genomic DNA
MOKI01000083
EMBL· GenBank· DDBJ
OJR47366.1
EMBL· GenBank· DDBJ
Genomic DNA
LRKC01000131
EMBL· GenBank· DDBJ
OKV08767.1
EMBL· GenBank· DDBJ
Genomic DNA
LRKC01000085
EMBL· GenBank· DDBJ
OKV15701.1
EMBL· GenBank· DDBJ
Genomic DNA
LRKC01000063
EMBL· GenBank· DDBJ
OKV16244.1
EMBL· GenBank· DDBJ
Genomic DNA
NHTF01000082
EMBL· GenBank· DDBJ
OWW49735.1
EMBL· GenBank· DDBJ
Genomic DNA
MRVZ01000150
EMBL· GenBank· DDBJ
PAU11705.1
EMBL· GenBank· DDBJ
Genomic DNA
NTEV01000158
EMBL· GenBank· DDBJ
PBU41979.1
EMBL· GenBank· DDBJ
Genomic DNA
PITP01000056
EMBL· GenBank· DDBJ
PKD84806.1
EMBL· GenBank· DDBJ
Genomic DNA
QEMT01000109
EMBL· GenBank· DDBJ
PWH50793.1
EMBL· GenBank· DDBJ
Genomic DNA
QKWZ01000002
EMBL· GenBank· DDBJ
PZT68208.1
EMBL· GenBank· DDBJ
Genomic DNA
CP057977
EMBL· GenBank· DDBJ
QMP48205.1
EMBL· GenBank· DDBJ
Genomic DNA
RDDM01000118
EMBL· GenBank· DDBJ
RLY56779.1
EMBL· GenBank· DDBJ
Genomic DNA
LT985314
EMBL· GenBank· DDBJ
SPE04202.1
EMBL· GenBank· DDBJ
Genomic DNA
UCVA01000007
EMBL· GenBank· DDBJ
SQK85071.1
EMBL· GenBank· DDBJ
Genomic DNA
VHKY01000023
EMBL· GenBank· DDBJ
TZE44617.1
EMBL· GenBank· DDBJ
Genomic DNA
UWVU01000003
EMBL· GenBank· DDBJ
VCX04990.1
EMBL· GenBank· DDBJ
Genomic DNA
UWXJ01000007
EMBL· GenBank· DDBJ
VCZ29744.1
EMBL· GenBank· DDBJ
Genomic DNA
CP122636
EMBL· GenBank· DDBJ
WHI04680.1
EMBL· GenBank· DDBJ
Genomic DNA
CP107130
EMBL· GenBank· DDBJ
WLM98690.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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