Q6UUU7 · Q6UUU7_ECOLX
- ProteinDihydropteroate synthase
- GenesulII
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids271 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Catalytic activity
- (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | dihydropteroate synthase activity | |
Molecular Function | metal ion binding | |
Biological Process | folic acid biosynthetic process | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydropteroate synthase
- EC number
- Short namesDHPS
- Alternative names
Gene names
Encoded on
- Plasmid RCS92_pI
- Plasmid p14EC029b
- Plasmid p14ec029b
- Plasmid p369
- Plasmid p39R861-4
- Plasmid p6148
- Plasmid p9123
- Plasmid pBK32533
- Plasmid pCA08
- Plasmid pCERC1
- Plasmid pE2865-3
- Plasmid pEC299-4
- Plasmid pESBL-305
- Plasmid pESCR
- Plasmid pF1253-2
- Plasmid pF862-1
- Plasmid pH2291-112
- Plasmid pHV295
- Plasmid pJIE250
- Plasmid pM5A24P
- Plasmid pPG010208
- Plasmid pQ1-1
- Plasmid pRAx
- Plasmid pRHB07-C04_3
- Plasmid pS7-S3K40-2
- Plasmid pSCEC2
- Plasmid pWJ1
- Plasmid pYDC637
- Plasmid pe2865-3 dna
- Plasmid peH4H
- Plasmid prhb07-c04_3
- Plasmid rcs92_pi
- Plasmid unnamed2
- Plasmid unnamed3
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionQ6UUU7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Sequence
- Sequence statusComplete
- Length271
- Mass (Da)28,470
- Last updated2005-05-10 v1
- MD5 Checksum11A14165B9F48E49CB97408B9E6B17F1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY360321 EMBL· GenBank· DDBJ | AAQ96758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU580136 EMBL· GenBank· DDBJ | ACF05513.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ705806 EMBL· GenBank· DDBJ | ACN66882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ621586 EMBL· GenBank· DDBJ | ACQ77658.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM371192 EMBL· GenBank· DDBJ | ADJ51134.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ023861 EMBL· GenBank· DDBJ | ADM62442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN012467 EMBL· GenBank· DDBJ | AEO37484.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU418932 EMBL· GenBank· DDBJ | AER36577.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX238460 EMBL· GenBank· DDBJ | AGI05147.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF152885 EMBL· GenBank· DDBJ | AGW01044.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ484629 EMBL· GenBank· DDBJ | AIF77882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP008737 EMBL· GenBank· DDBJ | AIG72717.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ868771 EMBL· GenBank· DDBJ | AIK66786.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP056256 EMBL· GenBank· DDBJ | AIY22894.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM377240 EMBL· GenBank· DDBJ | AJM91111.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP276584 EMBL· GenBank· DDBJ | AJT60270.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP345882 EMBL· GenBank· DDBJ | AKA87091.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP009233 EMBL· GenBank· DDBJ | AKD26863.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR494248 EMBL· GenBank· DDBJ | AKN35614.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT779550 EMBL· GenBank· DDBJ | ALG88139.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY924928 EMBL· GenBank· DDBJ | ASF81913.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP024143 EMBL· GenBank· DDBJ | AUK03928.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP031549 EMBL· GenBank· DDBJ | AXO10344.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP018811 EMBL· GenBank· DDBJ | BBF62998.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAUZHL010000005 EMBL· GenBank· DDBJ | CAK1213935.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
OY757098 EMBL· GenBank· DDBJ | CAK1258284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
OY757133 EMBL· GenBank· DDBJ | CAK1261757.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASFMQ010000027 EMBL· GenBank· DDBJ | EFB3616844.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASFMQ010000159 EMBL· GenBank· DDBJ | EFB3619008.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASEPP010000112 EMBL· GenBank· DDBJ | EFC2249544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASEPP010000286 EMBL· GenBank· DDBJ | EFC2250025.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASHPR010000027 EMBL· GenBank· DDBJ | EFC3525888.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASHPR010000239 EMBL· GenBank· DDBJ | EFC3528083.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASEBA010000071 EMBL· GenBank· DDBJ | EFC9752155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASEBA010000311 EMBL· GenBank· DDBJ | EFC9753211.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASVQO010000066 EMBL· GenBank· DDBJ | EFH3676890.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASVQO010000128 EMBL· GenBank· DDBJ | EFH3677008.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASXRC010000014 EMBL· GenBank· DDBJ | EFI0213782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASXRC010000147 EMBL· GenBank· DDBJ | EFI0216363.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJYL010000105 EMBL· GenBank· DDBJ | EFM1448699.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJYL010000178 EMBL· GenBank· DDBJ | EFM1448939.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAVTXU010000071 EMBL· GenBank· DDBJ | EGE1989295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAVTXU010000347 EMBL· GenBank· DDBJ | EGE1991219.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABLFQU030000112 EMBL· GenBank· DDBJ | EMM0028780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABLFQU030000246 EMBL· GenBank· DDBJ | EMM0029271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BGIE01000028 EMBL· GenBank· DDBJ | GDV20125.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABALL010000094 EMBL· GenBank· DDBJ | HAH1421554.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABALL010000173 EMBL· GenBank· DDBJ | HAH1421784.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABBJX010000064 EMBL· GenBank· DDBJ | HAH4527012.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABCJL010000008 EMBL· GenBank· DDBJ | HAH7770257.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABCJL010000055 EMBL· GenBank· DDBJ | HAH7771929.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABERK010000054 EMBL· GenBank· DDBJ | HAI5335158.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABERK010000170 EMBL· GenBank· DDBJ | HAI5335618.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABGKZ010000067 EMBL· GenBank· DDBJ | HAJ5153044.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABGKZ010000185 EMBL· GenBank· DDBJ | HAJ5153513.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABHXT010000147 EMBL· GenBank· DDBJ | HAJ5961542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABHXT010000181 EMBL· GenBank· DDBJ | HAJ5961707.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADUEU010000070 EMBL· GenBank· DDBJ | HBB1576219.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADUEU010000235 EMBL· GenBank· DDBJ | HBB1576777.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LGZN01000079 EMBL· GenBank· DDBJ | KNF63730.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JANWOR010000475 EMBL· GenBank· DDBJ | MDA4178993.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JANFIP010000131 EMBL· GenBank· DDBJ | MDS0708313.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RTJF01000097 EMBL· GenBank· DDBJ | MJL96607.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RTJF01000147 EMBL· GenBank· DDBJ | MJL96910.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RYCF01000100 EMBL· GenBank· DDBJ | MQK26602.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SQQU01000102 EMBL· GenBank· DDBJ | MQS33532.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WKUE01000051 EMBL· GenBank· DDBJ | MSI71472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WCEW01000096 EMBL· GenBank· DDBJ | MTE92534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WSXK01000110 EMBL· GenBank· DDBJ | MWF98079.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTML01000251 EMBL· GenBank· DDBJ | MWL00604.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTRC01000742 EMBL· GenBank· DDBJ | MWT24247.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WUIG01000033 EMBL· GenBank· DDBJ | MXJ07764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGYI010000168 EMBL· GenBank· DDBJ | NEM88862.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGYP010000032 EMBL· GenBank· DDBJ | NEN72358.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAJRI010000020 EMBL· GenBank· DDBJ | NGE90535.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MOHC01000049 EMBL· GenBank· DDBJ | OJN35008.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MOKI01000083 EMBL· GenBank· DDBJ | OJR47366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LRKC01000131 EMBL· GenBank· DDBJ | OKV08767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LRKC01000085 EMBL· GenBank· DDBJ | OKV15701.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LRKC01000063 EMBL· GenBank· DDBJ | OKV16244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NHTF01000082 EMBL· GenBank· DDBJ | OWW49735.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MRVZ01000150 EMBL· GenBank· DDBJ | PAU11705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NTEV01000158 EMBL· GenBank· DDBJ | PBU41979.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PITP01000056 EMBL· GenBank· DDBJ | PKD84806.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QEMT01000109 EMBL· GenBank· DDBJ | PWH50793.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QKWZ01000002 EMBL· GenBank· DDBJ | PZT68208.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP057977 EMBL· GenBank· DDBJ | QMP48205.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RDDM01000118 EMBL· GenBank· DDBJ | RLY56779.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LT985314 EMBL· GenBank· DDBJ | SPE04202.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UCVA01000007 EMBL· GenBank· DDBJ | SQK85071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VHKY01000023 EMBL· GenBank· DDBJ | TZE44617.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWVU01000003 EMBL· GenBank· DDBJ | VCX04990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWXJ01000007 EMBL· GenBank· DDBJ | VCZ29744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP122636 EMBL· GenBank· DDBJ | WHI04680.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP107130 EMBL· GenBank· DDBJ | WLM98690.1 EMBL· GenBank· DDBJ | Genomic DNA |