Q6URK8 · SMIP8_HUMAN

  • Protein
    Sperm microtubule inner protein 8
  • Gene
    SPMIP8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxonemal A tubule inner sheath
Cellular Componentsperm flagellum
Biological Processflagellated sperm motility

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sperm microtubule inner protein 8
  • Alternative names
    • Testis, prostate and placenta-expressed protein

Gene names

    • Name
      SPMIP8
    • Synonyms
      TEPP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6URK8
  • Secondary accessions
    • Q6URK7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_060223205in dbSNP:rs9934227

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 335 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003257771-216Sperm microtubule inner protein 8

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in testis, prostate and placenta.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Microtubule inner protein component of sperm flagellar doublet microtubules.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q6URK8HSPA5 P110212EBI-53990332, EBI-354921

Protein-protein interaction databases

Miscellaneous

Structure

3D structure databases

Family & Domains

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q6URK8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    216
  • Mass (Da)
    24,810
  • Last updated
    2024-01-24 v4
  • Checksum
    4C0EE021412BEE67
MARIIDLVPWDDGSTHVYASPAILLPMERQRNQLAGVKQQLYHPALPTLRHMDRDTVKACLPDEHCQSTTYCRKDEFDNAHFTLLGVPNKPLQCLDITATGQKLRNRYHEGKLAPIAPGINRVDWPCFTRAIEDWSHFVSSAGEFKLPCLRKRAEGLSGYAVRYLKPDVTQTWRYCLSQNPSLDRYGQKPLPFDSLNTFRSFGSSYSRVNYLTPWH

Q6URK8-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 174-174: R → RQEALCGAWAGRPCSPDSPRPYPCCPPQ

Sequence caution

The sequence AAI04459.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence AAI04460.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence AAR18688.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence AAR18689.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_032403174in isoform 2
Sequence conflict178in Ref. 1; AAR18688/AAR18689 and 3; AAI04459/AAI04460

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY363222
EMBL· GenBank· DDBJ
AAR18688.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AY363223
EMBL· GenBank· DDBJ
AAR18689.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC010543
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC104458
EMBL· GenBank· DDBJ
AAI04459.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC104459
EMBL· GenBank· DDBJ
AAI04460.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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