Q6U1P0 · Q6U1P0_BIOGL

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper A center.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological Processelectron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2

Gene names

    • Name
      COII
    • Synonyms
      COXII

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    Q6U1P0

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-42Helical
Transmembrane63-87Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-91Cytochrome oxidase subunit II transmembrane region profile
Domain92-215Cytochrome oxidase subunit II copper A binding

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    215
  • Mass (Da)
    24,370
  • Last updated
    2004-07-05 v1
  • Checksum
    5F2DD0754DC50E85
MSYWGQKLLFDPASPIQEEMILFHDHAMVLLLGIFSFVAFLGSKLIMNKLSSRNMLEAQTLETIWTIIPALLLVWLAFPSLRLLYLLDEQSKADLILKSTGHQWYWSYEVPTSSFDSYMISGDYSLLEVDNRVTLPYNVNTTVVTTSADVLHAFTIPSVGMKMDSVPGRLNSMNMFLNWPGVYYGQCSEICGANHSFMPIVVEAVHVDDFFFESA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY380567
EMBL· GenBank· DDBJ
AAQ74247.1
EMBL· GenBank· DDBJ
Genomic DNA
AY380531
EMBL· GenBank· DDBJ
AAQ75766.1
EMBL· GenBank· DDBJ
Genomic DNA
MG431965
EMBL· GenBank· DDBJ
AWK49500.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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