Q6TU48 · MAOX_DICDI

Function

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Divalent metal cations. Prefers magnesium or manganese.

Features

Showing features for active site, binding site, site.

Type
IDPosition(s)Description
Active site92Proton donor
Binding site145NAD+ (UniProtKB | ChEBI)
Active site163Proton acceptor
Binding site234a divalent metal cation (UniProtKB | ChEBI)
Binding site235a divalent metal cation (UniProtKB | ChEBI)
Binding site258a divalent metal cation (UniProtKB | ChEBI)
Binding site258NAD+ (UniProtKB | ChEBI)
Site258Important for activity
Binding site287-303NADP+ (UniProtKB | ChEBI)
Binding site400NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmalate dehydrogenase (decarboxylating) (NAD+) activity
Molecular Functionmalate dehydrogenase (decarboxylating) (NADP+) activity
Molecular Functionmalic enzyme activity
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Molecular Functionoxaloacetate decarboxylase activity
Biological Processmalate metabolic process
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADP-dependent malic enzyme
  • EC number
  • Short names
    NADP-ME
  • Alternative names
    • SrfA-induced gene A protein

Gene names

    • Name
      malA
    • Synonyms
      sigA
    • ORF names
      DDB_G0272524

Organism names

Accessions

  • Primary accession
    Q6TU48
  • Secondary accessions
    • Q559J5
    • Q7KWU9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003283791-544NADP-dependent malic enzyme

Proteomic databases

Expression

Tissue specificity

Expressed in the fruiting body.

Induction

By cAMP and the MADS-box protein srfA.

Developmental stage

Expressed at late stage of development (20 to 24 hours).

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias1-19Polar residues
Region1-22Disordered

Sequence similarities

Belongs to the malic enzymes family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    544
  • Mass (Da)
    60,652
  • Last updated
    2004-07-05 v1
  • MD5 Checksum
    E19350ADDB1399B18DFB8A5A11003627
MQNKPSFILRNPSANKGTGFNNEEREKLGLKGLLPPKVESLQEQSDRALSQFTSFNTNLERYIFLNCLRDRNETLFYYLLSNNLELMMPIIYTPTVGEACQKFGNEFRFAQGMYFASQDKGNIRAMMDNWPAEGVDIIVVSDGSRILGLGDLGTNGMGIPVGKLQLYVAGAGFCPTRTLPVIIDSGTNTKKYLEDKYYLGERHPRIPDSEYYPLVDEFLAAAFNKWPKVIVQFEDISNDHCFNLLDEYRNKYLCFNDDIQGTGSVILSGFINAVRSVQKPIKEHRMVFLGAGSAGIGVADCIMSLFDEAGVSKEEARKSFWFVDSKGLITTTRGDELTSQKKQYAREDYTYQLKSLLEVVRDVKPTAIIGLSGIGGSFSQEVIEEMAKHVEKPIVFALSNPTTNAECTAEQAYQWTDGRCIFASGSPFKPVEYKGKTFVPGQGNNMYIFPGLGLAASVCEAKHVTDAMIITAAKTLASFVEDSEVLTGKIYPGLQHIREISTRIAVKVIEKAYEEGMAQLPRPDNIEALVKSRQYVPSYDKSKN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-19Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY387644
EMBL· GenBank· DDBJ
AAQ95658.1
EMBL· GenBank· DDBJ
Genomic DNA
AAFI02000008
EMBL· GenBank· DDBJ
EAL71186.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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