Q6TH15 · EIF3D_DANRE

Function

function

mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenteukaryotic 43S preinitiation complex
Cellular Componenteukaryotic 48S preinitiation complex
Cellular Componenteukaryotic translation initiation factor 3 complex
Molecular FunctionmRNA cap binding
Molecular FunctionRNA binding
Molecular Functiontranslation initiation factor activity
Biological Processcap-dependent translational initiation
Biological Processformation of cytoplasmic translation initiation complex
Biological Processtranslational initiation

Keywords

Enzyme and pathway databases

    • R-DRE-156827L13a-mediated translational silencing of Ceruloplasmin expression
    • R-DRE-72689Formation of a pool of free 40S subunits
    • R-DRE-72695Formation of the ternary complex, and subsequently, the 43S complex
    • R-DRE-72702Ribosomal scanning and start codon recognition

Names & Taxonomy

Protein names

  • Recommended name
    Eukaryotic translation initiation factor 3 subunit D
  • Short names
    eIF3d
  • Alternative names
    • Eukaryotic translation initiation factor 3 subunit 7

Gene names

    • Name
      eif3d
    • Synonyms
      eif3s7
    • ORF names
      si:dkey-165I8.6

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q6TH15
  • Secondary accessions
    • A2BHH8
    • Q7T353

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003641341-552Eukaryotic translation initiation factor 3 subunit D

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region288-302RNA gate
Region525-552Disordered
Compositional bias530-552Acidic residues

Domain

The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.

Sequence similarities

Belongs to the eIF-3 subunit D family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    552
  • Mass (Da)
    64,090
  • Last updated
    2004-07-05 v1
  • Checksum
    C22F811A41D56177
MAKFHAPVIQDNPSGWGPCAVPEKFKDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDEASFQLVDTAKTQKTAYQRNRMRFAQRNLRRDKDRRTLTQFNMQTLPKSAKQKERDRMRLQKKFQKQFGVRQKWDQKSQAQLKPRDSSVEVRSDWEVKEEMDFPRLMKMRYMDVADPLDIECCGALEHYDKAFDRITTRNEKPLKSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMCCTRSVNSWDIIVQRVGNKLFFDKRDNSDFDLLTVSETANEPPQDEGSSLNSPRNLAMEATYINHNFSQQCLRMGGERYKFPNPNPFVEEDTEKSEVASVAYRYRRWKLGEDIDLIVRCEHDGVMTGANGEVSFINVKTLNEWDSRYCNGVDWRQKLDSQRGAVLATELKNNSYKLARWTCCAILAGSEYLKLGYVSRYHVKDSSRHVVLGTQQFKPNEFASQINLSMENAWGILRCVIDICRKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEDDEDEEDEEEDEDN

Sequence caution

The sequence CAM15128.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict, compositional bias.

Type
IDPosition(s)Description
Sequence conflict155-156in Ref. 3; CAM15128
Sequence conflict505in Ref. 4; AAH53250
Compositional bias530-552Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY648769
EMBL· GenBank· DDBJ
AAT68087.1
EMBL· GenBank· DDBJ
mRNA
AY398341
EMBL· GenBank· DDBJ
AAQ97774.1
EMBL· GenBank· DDBJ
mRNA
BX571960
EMBL· GenBank· DDBJ
CAM15128.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BC053250
EMBL· GenBank· DDBJ
AAH53250.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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