Q6TEN6 · WDR91_DANRE
- ProteinWD repeat-containing protein 91
- Genewdr91
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids724 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | early endosome membrane | |
Cellular Component | endosome membrane | |
Cellular Component | late endosome membrane | |
Molecular Function | phosphatidylinositol 3-kinase inhibitor activity | |
Molecular Function | phosphatidylinositol 3-kinase regulator activity | |
Biological Process | early endosome to late endosome transport | |
Biological Process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
Names & Taxonomy
Protein names
- Recommended nameWD repeat-containing protein 91
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ6TEN6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Early endosome membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000295750 | 1-724 | WD repeat-containing protein 91 | |||
Sequence: MASAVERTDDLVREYLIYRGFTSTLKHLDSEIKTDKEKGFRVDKIMDQLQLLIQSCDLTGLKEYWANLERRLFCRLEDVYKPTVSKLRTSLYRFYLIHTVQVKNVEKTQEFFQKQALELQAQAEWRDWFSLPFIPAPEQNPSFSAYFSRQWADTFLVSLHNFLSVLFQCMPLPALLSFDSEVQRITSLQEDNEQLRQTVFALQGESRLKKDEQMVHHKLPPYVQHMDRLGDTELDLVSSQRNVNMATPSRNFFSTFLPQGRRAPGRTAPGPQSSPTQSALGRKDAAASMQSSKAKDKEVKPPSVSSMTAELSTSHPRQRRHQDHEKERKELFSKHAAQGSEKKTDSDPDTQTEAPPDQTDSANQTRVCDVGGAGAEQPFIKLSQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVVKVWAFNPIMQTKATIMSKSPLLSLEWAAKPDRLLLLGSGVGTVKLYDTDAKKCLYEMTIDDVHPRILSLACSPSGTSFVCSAAAHSGAVMESEPRGSAPVSGQLLLWDTKTVKQQLQFALEPGPVAINCTAFNHNGNLLVTGAADGIIRLFDMQRYESALSWKAHDGEVYSVEFSYDENTVFSIGEDGKFVQWNIHRCGVKQSEYSLSQDAVGPFVLSGYSGYKQVQVPRGRLFAFDSEGQHVLTCSSTGGNIYRLNKAEAGLESVLSLAGHKAPVVTVDWCSAMDCGTCLTASMDGKIKLSTLLAQKP | ||||||
Modified residue | 274 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 178-207 | |||||
Sequence: FDSEVQRITSLQEDNEQLRQTVFALQGESR | ||||||
Region | 249-365 | Disordered | ||||
Sequence: SRNFFSTFLPQGRRAPGRTAPGPQSSPTQSALGRKDAAASMQSSKAKDKEVKPPSVSSMTAELSTSHPRQRRHQDHEKERKELFSKHAAQGSEKKTDSDPDTQTEAPPDQTDSANQT | ||||||
Compositional bias | 269-285 | Polar residues | ||||
Sequence: PGPQSSPTQSALGRKDA | ||||||
Compositional bias | 314-350 | Basic and acidic residues | ||||
Sequence: SHPRQRRHQDHEKERKELFSKHAAQGSEKKTDSDPDT | ||||||
Compositional bias | 351-365 | Polar residues | ||||
Sequence: QTEAPPDQTDSANQT | ||||||
Repeat | 389-428 | WD 1 | ||||
Sequence: EHHSSIMHCRVDCSGRRVASLDVDGVVKVWAFNPIMQTKA | ||||||
Repeat | 431-471 | WD 2 | ||||
Sequence: MSKSPLLSLEWAAKPDRLLLLGSGVGTVKLYDTDAKKCLYE | ||||||
Repeat | 499-532 | WD 3 | ||||
Sequence: AHSGAVMESEPRGSAPVSGQLLLWDTKTVKQQLQ | ||||||
Repeat | 537-576 | WD 4 | ||||
Sequence: PGPVAINCTAFNHNGNLLVTGAADGIIRLFDMQRYESALS | ||||||
Repeat | 579-618 | WD 5 | ||||
Sequence: AHDGEVYSVEFSYDENTVFSIGEDGKFVQWNIHRCGVKQS | ||||||
Repeat | 641-679 | WD 6 | ||||
Sequence: VQVPRGRLFAFDSEGQHVLTCSSTGGNIYRLNKAEAGLE | ||||||
Repeat | 686-724 | WD 7 | ||||
Sequence: GHKAPVVTVDWCSAMDCGTCLTASMDGKIKLSTLLAQKP |
Sequence similarities
Belongs to the WD repeat WDR91 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length724
- Mass (Da)80,767
- Last updated2007-07-24 v2
- Checksum008F055F47314E97
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 269-285 | Polar residues | ||||
Sequence: PGPQSSPTQSALGRKDA | ||||||
Compositional bias | 314-350 | Basic and acidic residues | ||||
Sequence: SHPRQRRHQDHEKERKELFSKHAAQGSEKKTDSDPDT | ||||||
Compositional bias | 351-365 | Polar residues | ||||
Sequence: QTEAPPDQTDSANQT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY423013 EMBL· GenBank· DDBJ | AAQ97989.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |