Q6TEK8 · VKORL_TAKRU
- ProteinVitamin K epoxide reductase complex subunit 1-like protein 1
- Genevkorc1l1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids175 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in vitamin K metabolism (PubMed:33154105).
Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress (PubMed:33154105).
Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins (By similarity).
Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress (PubMed:33154105).
Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins (By similarity).
Catalytic activity
- [protein]-disulfide + H2O + phylloquinone = 2,3-epoxyphylloquinone + [protein]-dithiolThis reaction proceeds in the backward direction.
Activity regulation
Inhibited by warfarin (coumadin) (PubMed:33154105).
Warfarin locks VKORC1 in both redox states into the closed conformation (PubMed:33154105).
Warfarin locks VKORC1 in both redox states into the closed conformation (PubMed:33154105).
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | quinone binding | |
Molecular Function | vitamin-K-epoxide reductase (warfarin-sensitive) activity | |
Biological Process | vitamin K metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVitamin K epoxide reductase complex subunit 1-like protein 1
- EC number
- Short namesVKORC1-like protein 1
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Tetraodontiformes > Tetradontoidea > Tetraodontidae > Takifugu
Accessions
- Primary accessionQ6TEK8
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-12 | Cytoplasmic | ||||
Sequence: MAAPVLRVSTPR | ||||||
Transmembrane | 13-35 | Helical | ||||
Sequence: WERIARVLVCLLGILLSLYAFHV | ||||||
Topological domain | 36-86 | Lumenal | ||||
Sequence: EREHARDPSYKALCDVSSSISCSKVFGSRWGRGFGLLGSIFGNDSALNQPN | ||||||
Transmembrane | 87-101 | Helical | ||||
Sequence: SVYGIVFYAFQLLLG | ||||||
Topological domain | 102-106 | Cytoplasmic | ||||
Sequence: MTVSA | ||||||
Transmembrane | 107-134 | Helical | ||||
Sequence: MAALILMTTSIMSVVGSLYLGYILYFVL | ||||||
Topological domain | 135-137 | Lumenal | ||||
Sequence: KDL | ||||||
Transmembrane | 138-159 | Helical | ||||
Sequence: CVICVTTYALNFILFVLNYKRL | ||||||
Topological domain | 160-175 | Cytoplasmic | ||||
Sequence: VYLNEAWKQKLQAKQD |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000457039 | 1-175 | Vitamin K epoxide reductase complex subunit 1-like protein 1 | |||
Sequence: MAAPVLRVSTPRWERIARVLVCLLGILLSLYAFHVEREHARDPSYKALCDVSSSISCSKVFGSRWGRGFGLLGSIFGNDSALNQPNSVYGIVFYAFQLLLGMTVSAMAALILMTTSIMSVVGSLYLGYILYFVLKDLCVICVTTYALNFILFVLNYKRLVYLNEAWKQKLQAKQD | ||||||
Disulfide bond | 49↔57 | Redox-active | ||||
Sequence: CDVSSSISC | ||||||
Disulfide bond | 138↔141 | Redox-active | ||||
Sequence: CVIC |
Keywords
- PTM
Structure
Family & Domains
Domain
Partially oxidized VKORC1 forms a cysteine adduct with substrates, vitamin K 2,3-epoxide, inducing a closed conformation, juxtaposing all cysteines (S-S or SH) for unimpeded electron transfer (PubMed:33154105).
VKOR becomes fully oxidized with an open conformation that releases reaction products, vitamin K quinone, or hydroquinone (PubMed:33154105).
Cys-138 and Cys-141 constitute the catalytic redox-active center (PubMed:33154105).
Cys-49 and Cys-57 are the cysteine pair that mediates transfer of reducing equivalents during catalysis (PubMed:33154105).
VKOR becomes fully oxidized with an open conformation that releases reaction products, vitamin K quinone, or hydroquinone (PubMed:33154105).
Cys-138 and Cys-141 constitute the catalytic redox-active center (PubMed:33154105).
Cys-49 and Cys-57 are the cysteine pair that mediates transfer of reducing equivalents during catalysis (PubMed:33154105).
Sequence similarities
Belongs to the VKOR family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length175
- Mass (Da)19,582
- Last updated2004-07-05 v1
- Checksum14869DAE88F3E723
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY423043 EMBL· GenBank· DDBJ | AAR82913.1 EMBL· GenBank· DDBJ | mRNA |