Q6TAC8 · C3AR_MACFA

Function

function

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functioncomplement component C3a receptor activity
Molecular FunctionG protein-coupled receptor activity
Biological Processchemotaxis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    C3a anaphylatoxin chemotactic receptor
  • Short names
    C3AR; C3a-R

Gene names

    • Name
      C3AR1

Organism names

Accessions

  • Primary accession
    Q6TAC8

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-23Extracellular
Transmembrane24-46Helical; Name=1
Topological domain47-57Cytoplasmic
Transmembrane58-80Helical; Name=2
Topological domain81-96Extracellular
Transmembrane97-118Helical; Name=3
Topological domain119-139Cytoplasmic
Transmembrane140-160Helical; Name=4
Topological domain161-337Extracellular
Transmembrane338-357Helical; Name=5
Topological domain358-374Cytoplasmic
Transmembrane375-397Helical; Name=6
Topological domain398-414Extracellular
Transmembrane415-435Helical; Name=7
Topological domain436-481Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000692031-481C3a anaphylatoxin chemotactic receptor
Glycosylation9N-linked (GlcNAc...) asparagine
Disulfide bond95↔172
Glycosylation168N-linked (GlcNAc...) asparagine
Modified residue174Sulfotyrosine
Modified residue184Sulfotyrosine
Glycosylation194N-linked (GlcNAc...) asparagine
Modified residue315Sulfotyrosine
Modified residue456Phosphoserine
Modified residue460Phosphothreonine

Keywords

PTM databases

Interaction

Subunit

Interacts with VGF-derived peptide TLQP-21 (By similarity).

Structure

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    481
  • Mass (Da)
    53,578
  • Last updated
    2004-07-05 v1
  • Checksum
    4C64DCBAB006BA4F
MAPFSAETNSTDLLSQPWNESPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQRTVNTVWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAITLDRCLVVFKPIWCQNHRNVGTACTICGCIWVVAFVMCIPVFVYREIFTTDNHSKCGYKFDLSGSLDYLDFYGNPLENRSLENIFQLPGEMNDRLDPSSFQANDHPWTVTTAFHTQTFQRPSADSLPKDSASHSPYSNVFKPAGVASPKIPSGFPIEGHKTSPLDDSDAFLSTHLKLFPSAASNSLYEYELPQDFQDYYSLGQFTYDNQVSTPLVAITITRLVVGFLLPSVIMIACYSFIVLRMQRGRFAKSQGKTLRVAVVVVTVFLVCWAPYHISGVLSLFTDPETPLGKTLMSWDHVFTALASANSCFNPFLYALLGKDFRKKARQSIQSILEAAFSEELTHSTHCSSNNVFSERNSISTTV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY426336
EMBL· GenBank· DDBJ
AAR06214.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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