Q6TAC8 · C3AR_MACFA
- ProteinC3a anaphylatoxin chemotactic receptor
- GeneC3AR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids481 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | complement component C3a receptor activity | |
Molecular Function | G protein-coupled receptor activity | |
Biological Process | chemotaxis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameC3a anaphylatoxin chemotactic receptor
- Short namesC3AR; C3a-R
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionQ6TAC8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-23 | Extracellular | ||||
Sequence: MAPFSAETNSTDLLSQPWNESPV | ||||||
Transmembrane | 24-46 | Helical; Name=1 | ||||
Sequence: ILSMVILSLTFLLGLPGNGLVLW | ||||||
Topological domain | 47-57 | Cytoplasmic | ||||
Sequence: VAGLKMQRTVN | ||||||
Transmembrane | 58-80 | Helical; Name=2 | ||||
Sequence: TVWFLHLTLADLLCCLSLPFSLA | ||||||
Topological domain | 81-96 | Extracellular | ||||
Sequence: HLALQGQWPYGRFLCK | ||||||
Transmembrane | 97-118 | Helical; Name=3 | ||||
Sequence: LIPSIIVLNMFASVFLLTAITL | ||||||
Topological domain | 119-139 | Cytoplasmic | ||||
Sequence: DRCLVVFKPIWCQNHRNVGTA | ||||||
Transmembrane | 140-160 | Helical; Name=4 | ||||
Sequence: CTICGCIWVVAFVMCIPVFVY | ||||||
Topological domain | 161-337 | Extracellular | ||||
Sequence: REIFTTDNHSKCGYKFDLSGSLDYLDFYGNPLENRSLENIFQLPGEMNDRLDPSSFQANDHPWTVTTAFHTQTFQRPSADSLPKDSASHSPYSNVFKPAGVASPKIPSGFPIEGHKTSPLDDSDAFLSTHLKLFPSAASNSLYEYELPQDFQDYYSLGQFTYDNQVSTPLVAITITR | ||||||
Transmembrane | 338-357 | Helical; Name=5 | ||||
Sequence: LVVGFLLPSVIMIACYSFIV | ||||||
Topological domain | 358-374 | Cytoplasmic | ||||
Sequence: LRMQRGRFAKSQGKTLR | ||||||
Transmembrane | 375-397 | Helical; Name=6 | ||||
Sequence: VAVVVVTVFLVCWAPYHISGVLS | ||||||
Topological domain | 398-414 | Extracellular | ||||
Sequence: LFTDPETPLGKTLMSWD | ||||||
Transmembrane | 415-435 | Helical; Name=7 | ||||
Sequence: HVFTALASANSCFNPFLYALL | ||||||
Topological domain | 436-481 | Cytoplasmic | ||||
Sequence: GKDFRKKARQSIQSILEAAFSEELTHSTHCSSNNVFSERNSISTTV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069203 | 1-481 | C3a anaphylatoxin chemotactic receptor | |||
Sequence: MAPFSAETNSTDLLSQPWNESPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQRTVNTVWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAITLDRCLVVFKPIWCQNHRNVGTACTICGCIWVVAFVMCIPVFVYREIFTTDNHSKCGYKFDLSGSLDYLDFYGNPLENRSLENIFQLPGEMNDRLDPSSFQANDHPWTVTTAFHTQTFQRPSADSLPKDSASHSPYSNVFKPAGVASPKIPSGFPIEGHKTSPLDDSDAFLSTHLKLFPSAASNSLYEYELPQDFQDYYSLGQFTYDNQVSTPLVAITITRLVVGFLLPSVIMIACYSFIVLRMQRGRFAKSQGKTLRVAVVVVTVFLVCWAPYHISGVLSLFTDPETPLGKTLMSWDHVFTALASANSCFNPFLYALLGKDFRKKARQSIQSILEAAFSEELTHSTHCSSNNVFSERNSISTTV | ||||||
Glycosylation | 9 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 95↔172 | |||||
Sequence: CKLIPSIIVLNMFASVFLLTAITLDRCLVVFKPIWCQNHRNVGTACTICGCIWVVAFVMCIPVFVYREIFTTDNHSKC | ||||||
Glycosylation | 168 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 174 | Sulfotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 184 | Sulfotyrosine | ||||
Sequence: Y | ||||||
Glycosylation | 194 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 315 | Sulfotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 456 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 460 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
PTM databases
Interaction
Subunit
Interacts with VGF-derived peptide TLQP-21 (By similarity).
Structure
Sequence
- Sequence statusComplete
- Length481
- Mass (Da)53,578
- Last updated2004-07-05 v1
- Checksum4C64DCBAB006BA4F
Keywords
- Technical term