Q6SAB9 · Q6SAB9_DROME
- Proteinreceptor protein-tyrosine kinase
- GeneEgfr
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1325 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ATP binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | ERBB signaling pathway | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of cell communication | |
Biological Process | regulation of cell population proliferation | |
Biological Process | regulation of signaling |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ6SAB9
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 768-791 | Helical | ||||
Sequence: MIFIITGAVLVPTICILCVVTYIC |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 837-1097 | Protein kinase | ||||
Sequence: LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFA | ||||||
Region | 1129-1194 | Disordered | ||||
Sequence: LAPTTDGSEAIAEPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVG | ||||||
Region | 1207-1228 | Disordered | ||||
Sequence: DDYLMPTCQPGPNNNNNMNNPN | ||||||
Compositional bias | 1214-1228 | Polar residues | ||||
Sequence: CQPGPNNNNNMNNPN | ||||||
Region | 1287-1325 | Disordered | ||||
Sequence: EVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNTETRV | ||||||
Compositional bias | 1303-1325 | Basic and acidic residues | ||||
Sequence: EYYNDTQRELQPLHRNRNTETRV |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,325
- Mass (Da)147,914
- Last updated2004-07-05 v1
- ChecksumE75C390A80F5CB54
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: C | ||||||
Compositional bias | 1214-1228 | Polar residues | ||||
Sequence: CQPGPNNNNNMNNPN | ||||||
Compositional bias | 1303-1325 | Basic and acidic residues | ||||
Sequence: EYYNDTQRELQPLHRNRNTETRV |