Q6R2S5 · Q6R2S5_BEMTA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids166 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Sternorrhyncha > Aleyrodoidea > Aleyrodidae > Aleyrodinae > Bemisia
Accessions
- Primary accessionQ6R2S5
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 21-40 | Helical | ||||
Sequence: GMIYAMLTIGILGFIVWGHH | ||||||
Transmembrane | 52-75 | Helical | ||||
Sequence: AYFTSATMIIAVPTGIKIFSWLAT | ||||||
Transmembrane | 87-109 | Helical | ||||
Sequence: LGLWFTGFLFLFTMGGLTGIILG | ||||||
Transmembrane | 129-155 | Helical | ||||
Sequence: YVLSMGIIFAIVGGVIYWFPLILGLTL |
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-166 | Cytochrome oxidase subunit I profile | ||||
Sequence: GIVSHLISSEAGKLEVFGSLGMIYAMLTIGILGFIVWGHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLGGMKSNKLSPLGLWFTGFLFLFTMGGLTGIILGNSSVDVCLHDTYFVVAHFHYVLSMGIIFAIVGGVIYWFPLILGLTLNNYSLVSQFYI |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length166
- Mass (Da)18,118
- Last updated2004-07-05 v1
- ChecksumD8F15B1361AE2972
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: G | ||||||
Non-terminal residue | 166 | |||||
Sequence: I |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY518185 EMBL· GenBank· DDBJ | AAS07858.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY518190 EMBL· GenBank· DDBJ | AAS07863.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY518192 EMBL· GenBank· DDBJ | AAS07864.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY518194 EMBL· GenBank· DDBJ | AAS07866.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY550273 EMBL· GenBank· DDBJ | AAS49514.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY550274 EMBL· GenBank· DDBJ | AAS49515.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY589496 EMBL· GenBank· DDBJ | AAS89985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY589497 EMBL· GenBank· DDBJ | AAS89986.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY589498 EMBL· GenBank· DDBJ | AAS89987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY587515 EMBL· GenBank· DDBJ | AAS99118.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY587517 EMBL· GenBank· DDBJ | AAS99120.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY596951 EMBL· GenBank· DDBJ | AAT09996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY596953 EMBL· GenBank· DDBJ | AAT09998.1 EMBL· GenBank· DDBJ | Genomic DNA |