CRP2 localization dynamics which affect CRP2 function are regulated by the formation of actin stress fibers in conjunction with smooth muscle cell differentiation.
Although CRP2 expression during development is independent of CArG box its expression in adult vascular smooth muscle requires CArG2 within intron 1 and might be mediated by myocardin factors.
CRP2 is a new downstream effector of cGMP/cGMP-dependent protein kinase I (cGKI)-mediated spinal nociceptive processing that plays an inhibitory role in the generation of inflammatory pain.
Presence of vascular smooth muscle cell-specific element(s) within bp -573 to -550 of CSRP2 5'-flanking sequence. Transcriptional regulation of CSRP2 gene is not dependent on dominant-negative serum response factor.
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