Q6QHT9 · CP19A_ANGJA
- ProteinAromatase
- Genecyp19a1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids511 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity
- 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | membrane | |
Molecular Function | aromatase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Biological Process | female gonad development | |
Biological Process | lipid metabolic process | |
Biological Process | response to estradiol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAromatase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Anguilliformes > Anguillidae > Anguilla
Accessions
- Primary accessionQ6QHT9
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000051966 | 1-511 | Aromatase | |||
Sequence: MKHLEEIVMEALMPASRNATQTAGRVVSGATAALLSGATAALLLLLCALLAAWSRSDKSSVPGPPFYMGIGPLLSYFRFIWTGIGTASNYYNERYGDIVRVWINGEETIILSRSSAVYQVLRKPQYTSRFGSKQGLRCIGMHERGIIFNNNIELWKKVRTYFAKALTGPGLQRTVAICVASTDSHLDQLEELTDLSGQVDILNLLRCTIVDISNQMFLRVPLNEKELLVKIQKYFEAWQTVLIRPDFLFKFEWMYKEHKEAAHELHEAMEILVEKKRKALEEAEKLDDADFATDLIFAQNHGELSAENVQQCILEMIIAAPDTMSISLFFMLMLLKQNPEVEQEILKELDTVIGDKKAENSNLQHLIIMESFINESLRYHPVVDFTMRKSLEDDVIEGYKVFKGTNIILNVGRMHKCEFFSKPNEFSLENFEKTVPNRFFQPFGSGPRSCVGKHISMVMMKAILATLLSRYTMCPRDGRTLNNIRKTNNLSQQLAEKDSELTMMFTPRRRQ |
Expression
Tissue specificity
Expressed in ovary. It is also found in the brain, but not in the spleen, head kidney, kidney or liver.
Structure
Sequence
- Sequence statusComplete
- Length511
- Mass (Da)58,308
- Last updated2004-07-05 v1
- ChecksumEAB2203A8A48D8C5