Q6QCM2 · Q6QCM2_HHV3
- ProteinCapsid scaffolding protein
- GeneORF33
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids605 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Assemblin: Protease that plays an essential role in virion assembly within the nucleus. Catalyzes the cleavage of the assembly protein after formation of the spherical procapsid. By that cleavage, the capsid matures and gains its icosahedral shape. The cleavage sites seem to include -Ala-Ser-, -Ala-Ala-, as well as Ala-Thr bonds. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging.
Assembly protein: Plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging.
Capsid scaffolding protein: Acts as a scaffold protein by binding major capsid protein in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein. Cleavages products are evicted from the capsid before or during DNA packaging.
Catalytic activity
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 52 | Charge relay system | |||
Active site | 120 | Charge relay system | |||
Active site | 139 | Charge relay system | |||
Site | 236-237 | Cleavage; by assemblin; Release site | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell nucleus | |
Molecular Function | identical protein binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | nuclear capsid assembly | |
Biological Process | proteolysis | |
Biological Process | viral release from host cell |
Keywords
- Molecular function
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCapsid scaffolding protein
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Strains
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Varicellovirus > Varicellovirus humanalpha3
- Virus hosts
Accessions
- Primary accessionQ6QCM2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_5040551018 | 1-236 | Assemblin | ||
Chain | PRO_5040551020 | 1-605 | Capsid scaffolding protein | ||
Chain | PRO_5040551019 | 237-605 | Assembly protein | ||
Post-translational modification
Capsid scaffolding protein: Capsid scaffolding protein is cleaved by assemblin after formation of the spherical procapsid. As a result, the capsid obtains its mature, icosahedral shape. Cleavages occur at two or more sites: release (R-site) and maturation (M-site).
Keywords
- PTM
Interaction
Subunit
Assemblin
Exists in a monomer-dimer equilibrium with the dimer being the active species.
Assembly protein
Homomultimer. Interacts with major capsid protein.
Capsid scaffolding protein
Homomultimer. Interacts with major capsid protein.
Protein-protein interaction databases
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 585-605 | Interaction with major capsid protein | |||
Domain
Region of interaction between pPR and pAP is called Amino conserved domain (ACD). The region of interaction with major capsid protein is called carboxyl conserved domain (CCD).
Sequence similarities
Belongs to the herpesviridae capsid scaffolding protein family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length605
- Mass (Da)66,047
- Last updated2004-07-05 v1
- MD5 Checksum819A9EF630FAD86B0E013AECEB8A1B79
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY548171 EMBL· GenBank· DDBJ | AAT07715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY548170 EMBL· GenBank· DDBJ | AAT07791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ479953 EMBL· GenBank· DDBJ | ABF21533.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ479954 EMBL· GenBank· DDBJ | ABF21606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ479955 EMBL· GenBank· DDBJ | ABF21679.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ479956 EMBL· GenBank· DDBJ | ABF21752.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ479958 EMBL· GenBank· DDBJ | ABF21898.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ479959 EMBL· GenBank· DDBJ | ABF21971.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ479961 EMBL· GenBank· DDBJ | ABF22117.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ479962 EMBL· GenBank· DDBJ | ABF22190.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ674250 EMBL· GenBank· DDBJ | ABH08485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU154348 EMBL· GenBank· DDBJ | ABW06908.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704690 EMBL· GenBank· DDBJ | AEW88010.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704691 EMBL· GenBank· DDBJ | AEW88082.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704692 EMBL· GenBank· DDBJ | AEW88154.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704693 EMBL· GenBank· DDBJ | AEW88226.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704694 EMBL· GenBank· DDBJ | AEW88298.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704695 EMBL· GenBank· DDBJ | AEW88370.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704699 EMBL· GenBank· DDBJ | AEW88658.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704700 EMBL· GenBank· DDBJ | AEW88730.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704701 EMBL· GenBank· DDBJ | AEW88802.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704702 EMBL· GenBank· DDBJ | AEW88874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704703 EMBL· GenBank· DDBJ | AEW88946.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN704710 EMBL· GenBank· DDBJ | AEW89450.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ972913 EMBL· GenBank· DDBJ | AFO85537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771889 EMBL· GenBank· DDBJ | AKG56102.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771891 EMBL· GenBank· DDBJ | AKG56248.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771892 EMBL· GenBank· DDBJ | AKG56321.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771893 EMBL· GenBank· DDBJ | AKG56394.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771894 EMBL· GenBank· DDBJ | AKG56467.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771895 EMBL· GenBank· DDBJ | AKG56540.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771896 EMBL· GenBank· DDBJ | AKG56613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771897 EMBL· GenBank· DDBJ | AKG56686.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771899 EMBL· GenBank· DDBJ | AKG56832.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771900 EMBL· GenBank· DDBJ | AKG56905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771901 EMBL· GenBank· DDBJ | AKG56978.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771902 EMBL· GenBank· DDBJ | AKG57051.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771903 EMBL· GenBank· DDBJ | AKG57124.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771907 EMBL· GenBank· DDBJ | AKG57416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771908 EMBL· GenBank· DDBJ | AKG57489.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771909 EMBL· GenBank· DDBJ | AKG57562.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771910 EMBL· GenBank· DDBJ | AKG57635.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771911 EMBL· GenBank· DDBJ | AKG57706.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771912 EMBL· GenBank· DDBJ | AKG57779.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771913 EMBL· GenBank· DDBJ | AKG57852.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771915 EMBL· GenBank· DDBJ | AKG57996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771916 EMBL· GenBank· DDBJ | AKG58071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771917 EMBL· GenBank· DDBJ | AKG58144.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771918 EMBL· GenBank· DDBJ | AKG58217.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771920 EMBL· GenBank· DDBJ | AKG58363.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP771923 EMBL· GenBank· DDBJ | AKG58582.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU926311 EMBL· GenBank· DDBJ | ANS12905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX262864 EMBL· GenBank· DDBJ | AON76499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX262865 EMBL· GenBank· DDBJ | AON76572.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX262866 EMBL· GenBank· DDBJ | AON76645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG764305 EMBL· GenBank· DDBJ | AYN61602.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG764312 EMBL· GenBank· DDBJ | AYN62113.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG764313 EMBL· GenBank· DDBJ | AYN62186.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ871403 EMBL· GenBank· DDBJ | CAI44876.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH709312 EMBL· GenBank· DDBJ | QCA42951.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH709346 EMBL· GenBank· DDBJ | QCA45433.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH709354 EMBL· GenBank· DDBJ | QCA46017.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH709356 EMBL· GenBank· DDBJ | QCA46163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH709361 EMBL· GenBank· DDBJ | QCA46528.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH709367 EMBL· GenBank· DDBJ | QCA46966.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH709369 EMBL· GenBank· DDBJ | QCA47112.1 EMBL· GenBank· DDBJ | Genomic DNA |