Q6Q0C1 · S2547_HUMAN
- ProteinSolute carrier family 25 member 47
- GeneSLC25A47
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids308 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Mitochondrial NAD+ transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD+ substrate to mitochondrial SIRT3 deacetylase and enables its NAD+-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated.
Catalytic activity
- NAD+(in) = NAD+(out)
- acetyl-CoA(in) = acetyl-CoA(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | mitochondrion | |
Molecular Function | acetyl-CoA transmembrane transporter activity | |
Molecular Function | NAD transmembrane transporter activity | |
Molecular Function | transmembrane transporter activity |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSolute carrier family 25 member 47
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6Q0C1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Mitochondrion outer membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 3-23 | Helical; Name=1 | ||||
Sequence: FVAGAIGGVCGVAVGYPLDTV | ||||||
Transmembrane | 49-69 | Helical; Name=2 | ||||
Sequence: VWGFYRGLSLPVCTVSLVSSV | ||||||
Transmembrane | 98-116 | Helical; Name=3 | ||||
Sequence: ITLSGCASGLVRVFLTSPT | ||||||
Transmembrane | 190-210 | Helical; Name=4 | ||||
Sequence: GHSFATYFLSYAVLCEWLSPA | ||||||
Transmembrane | 217-237 | Helical; Name=5 | ||||
Sequence: VPGVLVAGGCAGVLAWAVATP | ||||||
Transmembrane | 273-293 | Helical; Name=6 | ||||
Sequence: VLFKGLVLNCCRAFPVNMVVF |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 24 | Impaired NAD+ uptake. | ||||
Sequence: K → A | ||||||
Mutagenesis | 188 | Impaired NAD+ uptake. | ||||
Sequence: R → A | ||||||
Mutagenesis | 284 | Impaired NAD+ uptake. | ||||
Sequence: R → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 454 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000291779 | 1-308 | Solute carrier family 25 member 47 | |||
Sequence: MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEPKYTGIWHCVRDTYHRERVWGFYRGLSLPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAVLRLARGLLT |
Proteomic databases
PTM databases
Expression
Tissue specificity
Specifically expressed in liver.
Induction
Down-regulated in hepatocarcinoma.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 1-80 | Solcar 1 | ||||
Sequence: MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEPKYTGIWHCVRDTYHRERVWGFYRGLSLPVCTVSLVSSVSFGTYRHCLAH | ||||||
Repeat | 93-206 | Solcar 2 | ||||
Sequence: PTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEW | ||||||
Repeat | 215-302 | Solcar 3 | ||||
Sequence: PDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAVLRL |
Sequence similarities
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q6Q0C1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length308
- Mass (Da)33,435
- Last updated2004-07-05 v1
- Checksum995BC7342F99AFCC
Q6Q0C1-2
- Name2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G3V374 | G3V374_HUMAN | SLC25A47 | 162 |
Sequence caution
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY569438 EMBL· GenBank· DDBJ | AAS80155.1 EMBL· GenBank· DDBJ | mRNA | ||
AY570298 EMBL· GenBank· DDBJ | AAS77211.1 EMBL· GenBank· DDBJ | mRNA | ||
AB073385 EMBL· GenBank· DDBJ | BAD38636.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AK092001 EMBL· GenBank· DDBJ | BAG52460.1 EMBL· GenBank· DDBJ | mRNA | ||
BX248260 EMBL· GenBank· DDBJ | CAD62588.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
CH471061 EMBL· GenBank· DDBJ | EAW81697.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC137253 EMBL· GenBank· DDBJ | AAI37254.1 EMBL· GenBank· DDBJ | mRNA | ||
BC137254 EMBL· GenBank· DDBJ | AAI37255.1 EMBL· GenBank· DDBJ | mRNA |