Q6Q0C1 · S2547_HUMAN

  • Protein
    Solute carrier family 25 member 47
  • Gene
    SLC25A47
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Mitochondrial NAD+ transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD+ substrate to mitochondrial SIRT3 deacetylase and enables its NAD+-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentmitochondrion
Molecular Functionacetyl-CoA transmembrane transporter activity
Molecular FunctionNAD transmembrane transporter activity
Molecular Functiontransmembrane transporter activity

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier family 25 member 47
  • Alternative names
    • Hepatocellular carcinoma down-regulated mitochondrial carrier protein
    • Mitochondrial NAD(+) transporter SLC25A47

Gene names

    • Name
      SLC25A47
    • Synonyms
      C14orf68, HDMCP
    • ORF names
      HMFN1655

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6Q0C1
  • Secondary accessions
    • B2RP39
    • Q68CL2
    • Q6PZD8
    • Q86U14

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein
Mitochondrion outer membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane3-23Helical; Name=1
Transmembrane49-69Helical; Name=2
Transmembrane98-116Helical; Name=3
Transmembrane190-210Helical; Name=4
Transmembrane217-237Helical; Name=5
Transmembrane273-293Helical; Name=6

Keywords

Disease & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis24Impaired NAD+ uptake.
Mutagenesis188Impaired NAD+ uptake.
Mutagenesis284Impaired NAD+ uptake.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 454 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002917791-308Solute carrier family 25 member 47

Proteomic databases

PTM databases

Expression

Tissue specificity

Specifically expressed in liver.

Induction

Down-regulated in hepatocarcinoma.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat1-80Solcar 1
Repeat93-206Solcar 2
Repeat215-302Solcar 3

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q6Q0C1-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    308
  • Mass (Da)
    33,435
  • Last updated
    2004-07-05 v1
  • Checksum
    995BC7342F99AFCC
MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEPKYTGIWHCVRDTYHRERVWGFYRGLSLPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAVLRLARGLLT

Q6Q0C1-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
G3V374G3V374_HUMANSLC25A47162

Sequence caution

The sequence BAD38636.1 differs from that shown. Reason: Erroneous translation Wrong choice of frame.
The sequence CAD62588.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_02623325-30in isoform 2
Alternative sequenceVSP_02623431-308in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY569438
EMBL· GenBank· DDBJ
AAS80155.1
EMBL· GenBank· DDBJ
mRNA
AY570298
EMBL· GenBank· DDBJ
AAS77211.1
EMBL· GenBank· DDBJ
mRNA
AB073385
EMBL· GenBank· DDBJ
BAD38636.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AK092001
EMBL· GenBank· DDBJ
BAG52460.1
EMBL· GenBank· DDBJ
mRNA
BX248260
EMBL· GenBank· DDBJ
CAD62588.1
EMBL· GenBank· DDBJ
mRNA Different initiation
CH471061
EMBL· GenBank· DDBJ
EAW81697.1
EMBL· GenBank· DDBJ
Genomic DNA
BC137253
EMBL· GenBank· DDBJ
AAI37254.1
EMBL· GenBank· DDBJ
mRNA
BC137254
EMBL· GenBank· DDBJ
AAI37255.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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