Q6PQG3 · EPI10_PHYIN
- ProteinExtracellular protease inhibitor 10
- GeneEPI10
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids224 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Secreted effector that interacts with and inhibits the pathogenesis-related P69B subtilisin-like serine protease of host tomato (PubMed:15980196).
Inhibition of host proteases by a pathogen extracellular protease inhibitor forms a specific type of defense-counterdefense mechanism between plants and microbial pathogens (PubMed:15980196).
Inhibition of host proteases by a pathogen extracellular protease inhibitor forms a specific type of defense-counterdefense mechanism between plants and microbial pathogens (PubMed:15980196).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 32-33 | Reactive bond | ||||
Sequence: DV | ||||||
Site | 102-103 | Reactive bond | ||||
Sequence: DV | ||||||
Site | 169-170 | Reactive bond | ||||
Sequence: DN |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | serine-type endopeptidase inhibitor activity |
Keywords
- Molecular function
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameExtracellular protease inhibitor 10
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Oomycota > Peronosporales > Peronosporaceae > Phytophthora
Accessions
- Primary accessionQ6PQG3
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to host apoplast where it targets defense proteases for inhibition.
Keywords
- Cellular component
Phenotypes & Variants
Miscellaneous
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MKSAFTLSLALVAVTATISAAA | ||||||
Chain | PRO_5004279619 | 23-224 | Extracellular protease inhibitor 10 | |||
Sequence: DDNCSFGCLDVYKPVCGSNGETYSNSCYLRLASCKSNNGITEAGDGECASTPASSATPSPVTSSTGSTSGTVGCPDMCLDVYDPVSDENGKEYSNQCYMEMAKCKGTGYDDNKRSGNPGISTLDAERKLAFAPGYQGPPCGDMLCPDNYAPVCGSDGETYPNECDLGITSCNHPEQNITMVGEGPCPSQEQQQQQQQQQQKL | ||||||
Glycosylation | 25 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 26↔56 | |||||
Sequence: CSFGCLDVYKPVCGSNGETYSNSCYLRLASC | ||||||
Disulfide bond | 30↔49 | |||||
Sequence: CLDVYKPVCGSNGETYSNSC | ||||||
Disulfide bond | 38↔70 | |||||
Sequence: CGSNGETYSNSCYLRLASCKSNNGITEAGDGEC | ||||||
Disulfide bond | 96↔126 | |||||
Sequence: CPDMCLDVYDPVSDENGKEYSNQCYMEMAKC | ||||||
Disulfide bond | 100↔119 | |||||
Sequence: CLDVYDPVSDENGKEYSNQC | ||||||
Disulfide bond | 162↔193 | |||||
Sequence: CGDMLCPDNYAPVCGSDGETYPNECDLGITSC | ||||||
Disulfide bond | 167↔186 | |||||
Sequence: CPDNYAPVCGSDGETYPNEC | ||||||
Disulfide bond | 175↔208 | |||||
Sequence: CGSDGETYPNECDLGITSCNHPEQNITMVGEGPC | ||||||
Glycosylation | 199 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Interaction
Subunit
Interacts with host subtilisin-like protease P69B.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 23-72 | Kazal-like 1 | ||||
Sequence: DDNCSFGCLDVYKPVCGSNGETYSNSCYLRLASCKSNNGITEAGDGECAS | ||||||
Region | 69-92 | Disordered | ||||
Sequence: ECASTPASSATPSPVTSSTGSTSG | ||||||
Domain | 90-127 | Kazal-like 2 | ||||
Sequence: TSGTVGCPDMCLDVYDPVSDENGKEYSNQCYMEMAKCK | ||||||
Domain | 156-210 | Kazal-like 3 | ||||
Sequence: GYQGPPCGDMLCPDNYAPVCGSDGETYPNECDLGITSCNHPEQNITMVGEGPCPS | ||||||
Region | 202-224 | Disordered | ||||
Sequence: MVGEGPCPSQEQQQQQQQQQQKL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length224
- Mass (Da)23,481
- Last updated2004-07-05 v1
- ChecksumF37BD28D992DC6E9