Q6PQG3 · EPI10_PHYIN

Function

function

Secreted effector that interacts with and inhibits the pathogenesis-related P69B subtilisin-like serine protease of host tomato (PubMed:15980196).
Inhibition of host proteases by a pathogen extracellular protease inhibitor forms a specific type of defense-counterdefense mechanism between plants and microbial pathogens (PubMed:15980196).

Features

Showing features for site.

122420406080100120140160180200220
TypeIDPosition(s)Description
Site32-33Reactive bond
Site102-103Reactive bond
Site169-170Reactive bond

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionserine-type endopeptidase inhibitor activity

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Extracellular protease inhibitor 10
  • Alternative names
    • Secreted effector EPI10

Gene names

    • Name
      EPI10

Organism names

Accessions

  • Primary accession
    Q6PQG3

Organism-specific databases

Subcellular Location

Secreted
Note: Localizes to host apoplast where it targets defense proteases for inhibition.

Keywords

Phenotypes & Variants

Miscellaneous

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_500427961923-224Extracellular protease inhibitor 10
Glycosylation25N-linked (GlcNAc...) asparagine
Disulfide bond26↔56
Disulfide bond30↔49
Disulfide bond38↔70
Disulfide bond96↔126
Disulfide bond100↔119
Disulfide bond162↔193
Disulfide bond167↔186
Disulfide bond175↔208
Glycosylation199N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Induction

Expressed in zoospores (PubMed:15096512).
Expressed during host infection (PubMed:15980196).

Interaction

Subunit

Interacts with host subtilisin-like protease P69B.

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain23-72Kazal-like 1
Region69-92Disordered
Domain90-127Kazal-like 2
Domain156-210Kazal-like 3
Region202-224Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    224
  • Mass (Da)
    23,481
  • Last updated
    2004-07-05 v1
  • Checksum
    F37BD28D992DC6E9
MKSAFTLSLALVAVTATISAAADDNCSFGCLDVYKPVCGSNGETYSNSCYLRLASCKSNNGITEAGDGECASTPASSATPSPVTSSTGSTSGTVGCPDMCLDVYDPVSDENGKEYSNQCYMEMAKCKGTGYDDNKRSGNPGISTLDAERKLAFAPGYQGPPCGDMLCPDNYAPVCGSDGETYPNECDLGITSCNHPEQNITMVGEGPCPSQEQQQQQQQQQQKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY586282
EMBL· GenBank· DDBJ
AAT00509.1
EMBL· GenBank· DDBJ
mRNA

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