Q6PJG9 · LRFN4_HUMAN
- ProteinLeucine-rich repeat and fibronectin type-III domain-containing protein 4
- GeneLRFN4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids635 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | GABA-ergic synapse | |
Cellular Component | glutamatergic synapse | |
Cellular Component | plasma membrane | |
Cellular Component | postsynaptic density membrane | |
Biological Process | regulation of postsynaptic density assembly | |
Biological Process | regulation of presynapse assembly | |
Biological Process | synaptic membrane adhesion |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLeucine-rich repeat and fibronectin type-III domain-containing protein 4
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6PJG9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 17-518 | Extracellular | ||||
Sequence: CPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGRDAEASPAPLVLSFSGNPLHCNCELLWLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEATARVELRVLALPHGGNSSAEGGRPGPSDIAASARTAAEGEGTLESEPAVQVTEVTATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPASPLCHALQAHVLGGTL | ||||||
Transmembrane | 519-539 | Helical | ||||
Sequence: TVAVGGVLVAALLVFTVALLV | ||||||
Topological domain | 540-635 | Cytoplasmic | ||||
Sequence: RGRGAGNGRLPLKLSHVQSQTNGGPSPTPKAHPPRSPPPRPQRSCSLDLGDAGCYGYARRLGGAWARRSHSVHGGLLGAGCRGVGGSAERLEESVV |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_024499 | 340 | in dbSNP:rs3741194 | |||
Sequence: V → A | ||||||
Mutagenesis | 633-635 | Loss of DLG1-, DLG3- and DLG4-binding. | ||||
Sequence: Missing |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 771 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Signal | 1-16 | UniProt | |||||
Sequence: MAPPLLLLLLASGAAA | |||||||
Chain | PRO_0000014843 | 17-635 | UniProt | Leucine-rich repeat and fibronectin type-III domain-containing protein 4 | |||
Sequence: CPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGRDAEASPAPLVLSFSGNPLHCNCELLWLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEATARVELRVLALPHGGNSSAEGGRPGPSDIAASARTAAEGEGTLESEPAVQVTEVTATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPASPLCHALQAHVLGGTLTVAVGGVLVAALLVFTVALLVRGRGAGNGRLPLKLSHVQSQTNGGPSPTPKAHPPRSPPPRPQRSCSLDLGDAGCYGYARRLGGAWARRSHSVHGGLLGAGCRGVGGSAERLEESVV | |||||||
Glycosylation | 25 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 70 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 302↔351 | UniProt | |||||
Sequence: CRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTC | |||||||
Glycosylation | 324 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 333 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 376 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 440 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 565 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 575 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 583 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 585 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 585 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 608 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 610 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 626 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 626 | PRIDE | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Can form heteromeric complexes with LRFN1, LRFN2, LRFN3 and LRFN5. Unable to form homophilic interactions across cell junctions (By similarity).
Interacts with DLG1, DLG2, DLG3 and DLG4
Interacts with DLG1, DLG2, DLG3 and DLG4
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q6PJG9 | ADAMTSL4 Q6UY14-3 | 3 | EBI-7910762, EBI-10173507 | |
BINARY | Q6PJG9 | CYSRT1 A8MQ03 | 3 | EBI-7910762, EBI-3867333 | |
BINARY | Q6PJG9 | KRTAP1-1 Q07627 | 3 | EBI-7910762, EBI-11959885 | |
BINARY | Q6PJG9 | KRTAP1-3 Q8IUG1 | 3 | EBI-7910762, EBI-11749135 | |
BINARY | Q6PJG9 | KRTAP10-8 P60410 | 3 | EBI-7910762, EBI-10171774 | |
BINARY | Q6PJG9 | KRTAP6-2 Q3LI66 | 3 | EBI-7910762, EBI-11962084 | |
BINARY | Q6PJG9 | NOTCH2NLA Q7Z3S9 | 3 | EBI-7910762, EBI-945833 | |
BINARY | Q6PJG9 | NOTCH2NLC P0DPK4 | 3 | EBI-7910762, EBI-22310682 | |
BINARY | Q6PJG9 | P4HB P07237 | 3 | EBI-7910762, EBI-395883 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, repeat, region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-48 | LRRNT | ||||
Sequence: CPLPCVCQNLSESLSTLCAHRGLLFVPPNVDR | ||||||
Repeat | 49-70 | LRR 1 | ||||
Sequence: RTVELRLADNFIQALGPPDFRN | ||||||
Repeat | 73-94 | LRR 2 | ||||
Sequence: GLVDLTLSRNAITRIGARAFGD | ||||||
Repeat | 97-118 | LRR 3 | ||||
Sequence: SLRSLHLDGNRLVELGTGSLRG | ||||||
Repeat | 121-142 | LRR 4 | ||||
Sequence: NLQHLILSGNQLGRIAPGAFDD | ||||||
Repeat | 146-161 | LRR 5 | ||||
Sequence: SLEDLDLSYNNLRQVP | ||||||
Repeat | 170-191 | LRR 6 | ||||
Sequence: ALHTLNLDHNLIDALPPGAFAQ | ||||||
Repeat | 194-215 | LRR 7 | ||||
Sequence: QLSRLDLTSNRLATLAPDPLFS | ||||||
Domain | 234-280 | LRRCT | ||||
Sequence: NPLHCNCELLWLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEP | ||||||
Domain | 281-367 | Ig-like | ||||
Sequence: PLIARHTQRLWVLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEATARVELR | ||||||
Region | 373-410 | Disordered | ||||
Sequence: HGGNSSAEGGRPGPSDIAASARTAAEGEGTLESEPAVQ | ||||||
Domain | 405-502 | Fibronectin type-III | ||||
Sequence: SEPAVQVTEVTATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPA | ||||||
Region | 555-583 | Disordered | ||||
Sequence: HVQSQTNGGPSPTPKAHPPRSPPPRPQRS | ||||||
Compositional bias | 566-580 | Pro residues | ||||
Sequence: PTPKAHPPRSPPPRP | ||||||
Motif | 632-635 | PDZ-binding | ||||
Sequence: ESVV |
Domain
The PDZ-binding motif is required for neurite outgrowth promotion (By similarity).
This motif is also involved in DLG1-, DLG3- and DLG4-binding
This motif is also involved in DLG1-, DLG3- and DLG4-binding
Sequence similarities
Belongs to the LRFN family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length635
- Mass (Da)66,860
- Last updated2004-07-05 v1
- Checksum13E66645A17A92EE
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E7ENX6 | E7ENX6_HUMAN | LRFN4 | 418 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 566-580 | Pro residues | ||||
Sequence: PTPKAHPPRSPPPRP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC000207 EMBL· GenBank· DDBJ | AAH00207.2 EMBL· GenBank· DDBJ | mRNA | ||
BC015581 EMBL· GenBank· DDBJ | AAH15581.2 EMBL· GenBank· DDBJ | mRNA | ||
BC027475 EMBL· GenBank· DDBJ | AAH27475.2 EMBL· GenBank· DDBJ | mRNA | ||
BC094813 EMBL· GenBank· DDBJ | AAH94813.1 EMBL· GenBank· DDBJ | mRNA | ||
AB209005 EMBL· GenBank· DDBJ | BAD92242.1 EMBL· GenBank· DDBJ | mRNA |