Q6PGP7 · SKI3_HUMAN
- ProteinSuperkiller complex protein 3
- GeneSKIC3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1564 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588).
The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588).
SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463).
In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656).
The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588).
SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463).
In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | euchromatin | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | Ski complex | |
Biological Process | nuclear-transcribed mRNA catabolic process | |
Biological Process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay | |
Biological Process | rescue of stalled ribosome |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuperkiller complex protein 3
- Short namesSki3
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6PGP7
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Involvement in disease
Trichohepatoenteric syndrome 1 (THES1)
- Note
- DescriptionA syndrome characterized by intrauterine growth retardation, severe diarrhea in infancy requiring total parenteral nutrition, facial dysmorphism, immunodeficiency, and hair abnormalities, mostly trichorrhexis nodosa. Hepatic involvement contributes to the poor prognosis of affected patients.
- See alsoMIM:222470
Natural variants in THES1
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_067957 | 251 | G>R | in THES1; dbSNP:rs763816083 | |
VAR_067958 | 1283 | D>N | in THES1 | |
VAR_067959 | 1505 | L>S | in THES1; dbSNP:rs376720108 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_067957 | 251 | in THES1; dbSNP:rs763816083 | |||
Sequence: G → R | ||||||
Natural variant | VAR_027705 | 437 | in dbSNP:rs17084873 | |||
Sequence: L → V | ||||||
Natural variant | VAR_065297 | 860-878 | found in a THES1 patient | |||
Sequence: Missing | ||||||
Natural variant | VAR_065298 | 1077 | found in a THES1 patient | |||
Sequence: A → D | ||||||
Natural variant | VAR_065299 | 1270 | found in a THES1 patient; dbSNP:rs146627706 | |||
Sequence: P → A | ||||||
Natural variant | VAR_067958 | 1283 | in THES1 | |||
Sequence: D → N | ||||||
Natural variant | VAR_027706 | 1296 | in dbSNP:rs2303650 | |||
Sequence: R → S | ||||||
Natural variant | VAR_065300 | 1485 | found in a THES1 patient | |||
Sequence: L → R | ||||||
Natural variant | VAR_067959 | 1505 | in THES1; dbSNP:rs376720108 | |||
Sequence: L → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,715 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Chain | PRO_0000251722 | 2-1564 | Superkiller complex protein 3 | |||
Sequence: SSKEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQGLANLYEKYNHINAKDDLPGVYQKLLDLYESVDKQKWCDVCKKLVDLYYQEKKHLEVARTWHKLIKTRQEQGAENEELHQLWRKLTQFLAESTEDQNNETQQLLFTAFENALGLSDKIPSEDHQVLYRHFIQSLSKFPHESARLKKACEGMINIYPTVQYPLEVLCLHLIESGNLTDEGQQYCCRLVEMDSKSGPGLIGLGIKALQDKKYEDAVRNLTEGLKESPVCTSGWYHLAEAQVKMHRPKEAVLSCSQALKIVDNLGASGNSLYQRNLCLHLKAEALIKLSDYDSSEEAIRTLDQISDADNIPGLLVLKSLAYRNKGSFDEAAKIMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGEETRKDKTKALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGCYRKAFELDDTDAESGAAAVDLSVELEDMEMALAILTTVTQKASAGTAKWAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKAALVDYLDGKAVDYIEKALEYFTCALQHRADVSCLWKLAGDACTCLYAVAPSKVNVHVLGVLLGQKEGKQVLKKNELLHLGGRCYGRALKLMSTSNTWCDLGINYYRQAQHLAETGSNMNDLKELLEKSLHCLKKAVRLDSNNHLYWNALGVVACYSGIGNYALAQHCFIKSIQSEQINAVAWTNLGVLYLTNENIEQAHEAFKMAQSLDPSYLMCWIGQALIAEAVGSYDTMDLFRHTTELNMHTEGALGYAYWVCTTLQDKSNRETELYQYNILQMNAIPAAQVILNKYVERIQNYAPAFTMLGYLNEHLQLKKEAANAYQRAILLLQTAEDQDTYNVAIRNYGRLLCSTGEYDKAIQAFKSTPLEVLEDIIGFALALFMKGLYKESSKAYERALSIVESEQDKAHILTALAITEYKQGKTDVAKTLLFKCSILKEPTTESLQALCALGLAMQDATLSKAALNELLKHIKHKDSNYQRCLLTSAIYALQGRSVAVQKQISKAVHSNPGDPALWSLLSRVVAQYAQRNAKGGVVAGNVAHILDSNHGKKALLYTAVNQLAMGSSSAEDEKNTALKTIQKAALLSPGDPAIWAGLMAACHADDKLALVNNTQPKRIDLYLALLSAVSASIKDEKFFENYNQSLEKWSLSQAVTGLIDTGRISEAETLCTKNLKSNPDQPAVILLLRQVQCKPLLESQKPLPDAVLEELQKTVMSNSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQLASQRGSWSGKLSSLLRLALLALKVCMANISNDHWPSLVQEATTEALKLCFCPLAVLLQALLQFKRKMGARETRRLLERVVYQPGYPKSIASTARWYLLRHLYAKDDYELIDVLVNNAKTHGDTRALELNQRLSSQ |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed with the highest levels observed in vascular tissues, lymph node, pituitary, lung and intestine. Not expressed in the liver.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Component of the SKI complex which consists of SKIC2, SKIC3 and SKIC8 (PubMed:16024656, PubMed:32006463, PubMed:35120588).
Interacts with PAF1 (PubMed:16024656).
Interacts with PAF1 (PubMed:16024656).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q6PGP7 | PAF1 Q8N7H5 | 2 | EBI-6083436, EBI-2607770 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 6-39 | TPR 1 | ||||
Sequence: VKTALKSARDAIRNKEYKEALKHCKTVLKQEKNN | ||||||
Repeat | 40-73 | TPR 2 | ||||
Sequence: YNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQ | ||||||
Repeat | 272-305 | TPR 3 | ||||
Sequence: GPGLIGLGIKALQDKKYEDAVRNLTEGLKESPVC | ||||||
Repeat | 307-339 | TPR 4 | ||||
Sequence: SGWYHLAEAQVKMHRPKEAVLSCSQALKIVDNL | ||||||
Repeat | 386-419 | TPR 5 | ||||
Sequence: PGLLVLKSLAYRNKGSFDEAAKIMEDLLSSYPDL | ||||||
Repeat | 420-453 | TPR 6 | ||||
Sequence: AEVHALEALIHFTKKDYLQAEKCFQRALEKDTEV | ||||||
Repeat | 455-492 | TPR 7 | ||||
Sequence: EYHYQLGLTYWFMGEETRKDKTKALTHFLKAARLDTYM | ||||||
Repeat | 493-527 | TPR 8 | ||||
Sequence: GKVFCYLGHYYRDVVGDKNRARGCYRKAFELDDTD | ||||||
Repeat | 564-597 | TPR 9 | ||||
Sequence: KWAWLRRGLYYLKAGQHSQAVADLQAALRADPKD | ||||||
Repeat | 598-631 | TPR 10 | ||||
Sequence: FNCWESLGEAYLSRGGYTTALKSFTKASELNPES | ||||||
Repeat | 633-665 | TPR 11 | ||||
Sequence: YSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDY | ||||||
Repeat | 679-713 | TPR 12 | ||||
Sequence: MAKAALVDYLDGKAVDYIEKALEYFTCALQHRADV | ||||||
Repeat | 790-824 | TPR 13 | ||||
Sequence: AQHLAETGSNMNDLKELLEKSLHCLKKAVRLDSNN | ||||||
Repeat | 826-860 | TPR 14 | ||||
Sequence: LYWNALGVVACYSGIGNYALAQHCFIKSIQSEQIN | ||||||
Repeat | 861-894 | TPR 15 | ||||
Sequence: AVAWTNLGVLYLTNENIEQAHEAFKMAQSLDPSY | ||||||
Repeat | 980-1013 | TPR 16 | ||||
Sequence: APAFTMLGYLNEHLQLKKEAANAYQRAILLLQTA | ||||||
Repeat | 1020-1054 | TPR 17 | ||||
Sequence: NVAIRNYGRLLCSTGEYDKAIQAFKSTPLEVLEDI | ||||||
Repeat | 1056-1084 | TPR 18 | ||||
Sequence: GFALALFMKGLYKESSKAYERALSIVESE | ||||||
Repeat | 1326-1359 | TPR 19 | ||||
Sequence: KWSLSQAVTGLIDTGRISEAETLCTKNLKSNPDQ | ||||||
Repeat | 1400-1433 | TPR 20 | ||||
Sequence: VPAWQWLAHVYQSQGMMRAAEMCYRKSLQLASQR |
Sequence similarities
Belongs to the SKI3 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,564
- Mass (Da)175,486
- Last updated2004-07-05 v1
- Checksum12D6B45B4A6F367A
Computationally mapped potential isoform sequences
There are 21 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D6RDA0 | D6RDA0_HUMAN | SKIC3 | 95 | ||
D6RCE2 | D6RCE2_HUMAN | SKIC3 | 611 | ||
H0Y964 | H0Y964_HUMAN | SKIC3 | 130 | ||
H0Y915 | H0Y915_HUMAN | SKIC3 | 415 | ||
A0A8V8TN82 | A0A8V8TN82_HUMAN | SKIC3 | 58 | ||
A0A8V8TN92 | A0A8V8TN92_HUMAN | SKIC3 | 834 | ||
A0A8V8TNA2 | A0A8V8TNA2_HUMAN | SKIC3 | 720 | ||
A0A8V8TNJ4 | A0A8V8TNJ4_HUMAN | SKIC3 | 1494 | ||
A0A8V8TNJ9 | A0A8V8TNJ9_HUMAN | SKIC3 | 684 | ||
A0A8V8TNK4 | A0A8V8TNK4_HUMAN | SKIC3 | 868 | ||
A0A8V8TNK9 | A0A8V8TNK9_HUMAN | SKIC3 | 809 | ||
A0A8V8TLR0 | A0A8V8TLR0_HUMAN | SKIC3 | 846 | ||
A0A8V8TLS3 | A0A8V8TLS3_HUMAN | SKIC3 | 1561 | ||
A0A8V8TLT2 | A0A8V8TLT2_HUMAN | SKIC3 | 1561 | ||
A0A8V8TLT7 | A0A8V8TLT7_HUMAN | SKIC3 | 912 | ||
A0A8V8TLU2 | A0A8V8TLU2_HUMAN | SKIC3 | 1223 | ||
A0A8V8TLU5 | A0A8V8TLU5_HUMAN | SKIC3 | 1016 | ||
A0A8V8TM98 | A0A8V8TM98_HUMAN | SKIC3 | 333 | ||
A0A8V8TMA3 | A0A8V8TMA3_HUMAN | SKIC3 | 225 | ||
A0A8V8TMA8 | A0A8V8TMA8_HUMAN | SKIC3 | 1578 | ||
A0A8V8TMB2 | A0A8V8TMB2_HUMAN | SKIC3 | 1562 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB002370 EMBL· GenBank· DDBJ | BAA20827.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC015163 EMBL· GenBank· DDBJ | AAH15163.1 EMBL· GenBank· DDBJ | mRNA | ||
BC056893 EMBL· GenBank· DDBJ | AAH56893.1 EMBL· GenBank· DDBJ | mRNA |