Q6PFR5 · TRA2A_MOUSE

  • Protein
    Transformer-2 protein homolog alpha
  • Gene
    Tra2a
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componentspliceosomal complex
Molecular Functionidentical protein binding
Molecular FunctionRNA binding
Biological ProcessmRNA processing
Biological Processpositive regulation of mRNA splicing, via spliceosome
Biological ProcessRNA splicing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transformer-2 protein homolog alpha
  • Short names
    TRA-2 alpha; TRA2-alpha
  • Alternative names
    • Transformer-2 protein homolog A

Gene names

    • Name
      Tra2a

Organism names

  • Taxonomic identifier
  • Strain
    • Czech II
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6PFR5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, cross-link.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
Modified residue2Phosphoserine
ChainPRO_00000819822-281Transformer-2 protein homolog alpha
Modified residue14Phosphoserine
Modified residue24Phosphothreonine
Modified residue80Phosphoserine
Modified residue82Phosphoserine
Modified residue84Phosphoserine
Modified residue86Phosphothreonine
Modified residue94Phosphoserine
Modified residue96Phosphoserine
Cross-link196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue200Phosphothreonine
Modified residue202Phosphothreonine
Modified residue233Omega-N-methylarginine
Modified residue237Phosphoserine

Post-translational modification

Phosphorylated in the RS domains.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in inner ear.

Interaction

Subunit

Binds to A3 enhancer proteins SRp75, SRp55, SRp40 and SRp30 (Probable). Interacts with ILDR1 (via C-terminus) and ILDR2 (PubMed:28785060).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q6PFR5Nol3 Q9D1X04EBI-913075, EBI-913097
BINARY Q6PFR5Srsf7 Q8BL974EBI-913075, EBI-913123
BINARY Q6PFR5Tra2a Q6PFR52EBI-913075, EBI-913075

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-116Disordered
Compositional bias14-37Polar residues
Compositional bias50-86Basic residues
Domain117-195RRM
Region196-223Linker
Region199-281Disordered
Compositional bias234-261Basic and acidic residues

Sequence similarities

Belongs to the splicing factor SR family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    281
  • Mass (Da)
    32,316
  • Last updated
    2004-07-05 v1
  • Checksum
    8074C89D4494D7F0
MSDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRSRRHSHRRYTRSRSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYEDYDYRRRSPSPYYSRYRSRSRSRSYSPRRY

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0N4SVC2A0A0N4SVC2_MOUSETra2a280
A0A0N4SV13A0A0N4SV13_MOUSETra2a59
E9QP00E9QP00_MOUSETra2a282

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias14-37Polar residues
Compositional bias50-86Basic residues
Compositional bias234-261Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC057448
EMBL· GenBank· DDBJ
AAH57448.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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