Q6PFE7 · TEFF1_MOUSE
- ProteinTomoregulin-1
- GeneTmeff1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids372 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (By similarity).
Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (By similarity).
Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (By similarity).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 97-98 | Reactive bond | ||||
Sequence: TN | ||||||
Site | 188-189 | Reactive bond | ||||
Sequence: GY |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane |
Keywords
- Molecular function
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameTomoregulin-1
- Short namesTR-1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ6PFE7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 37-322 | Extracellular | ||||
Sequence: SNQPAGGGGDCPGGRGKSNCSELNLRESDIRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKDITVVARGPCYSDNGSGSGEGEEEGSGAGAHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDVSLLGKKDDGLQYRPDVKDAGDEREDVYIGSHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHV | ||||||
Transmembrane | 323-343 | Helical | ||||
Sequence: LIAAIIGAVQIAIIVAIVMCI | ||||||
Topological domain | 344-372 | Cytoplasmic | ||||
Sequence: TRKCPKNNRGRRQKQNLGHFTSDTSSRMV |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-36 | |||||
Sequence: MGAQAPLRLPAAPPLAVCGYTSVLLLFAFCLPGSRA | ||||||
Chain | PRO_0000286057 | 37-372 | Tomoregulin-1 | |||
Sequence: SNQPAGGGGDCPGGRGKSNCSELNLRESDIRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKDITVVARGPCYSDNGSGSGEGEEEGSGAGAHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDVSLLGKKDDGLQYRPDVKDAGDEREDVYIGSHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSDTSSRMV | ||||||
Glycosylation | 55 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 91↔121 | |||||
Sequence: CQFQCHTNYIPVCGSNGDTYQNECFLRRAAC | ||||||
Disulfide bond | 95↔114 | |||||
Sequence: CHTNYIPVCGSNGDTYQNEC | ||||||
Disulfide bond | 103↔135 | |||||
Sequence: CGSNGDTYQNECFLRRAACKHQKDITVVARGPC | ||||||
Glycosylation | 139 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 182↔213 | |||||
Sequence: CNIDCSGYSFNPVCASDGSSYNNPCFVREASC | ||||||
Disulfide bond | 186↔206 | |||||
Sequence: CSGYSFNPVCASDGSSYNNPC | ||||||
Disulfide bond | 195↔227 | |||||
Sequence: CASDGSSYNNPCFVREASCIKQEQIDIRHLGHC | ||||||
Disulfide bond | 267↔280 | |||||
Sequence: CPENLNGYCIHGKC | ||||||
Disulfide bond | 275↔291 | |||||
Sequence: CIHGKCEFIYSTQKASC | ||||||
Disulfide bond | 293↔302 | |||||
Sequence: CESGYTGQHC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain, neurointermediate lobe, pars distalis, pancreas, ovary and testis (PubMed:11025219, PubMed:11165370).
Developmental stage
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 90-137 | Kazal-like 1 | ||||
Sequence: ACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKDITVVARGPCYS | ||||||
Region | 139-161 | Disordered | ||||
Sequence: NGSGSGEGEEEGSGAGAHRKHSK | ||||||
Domain | 181-229 | Kazal-like 2 | ||||
Sequence: VCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTD | ||||||
Domain | 263-303 | EGF-like | ||||
Sequence: SHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCE | ||||||
Region | 351-372 | Disordered | ||||
Sequence: NRGRRQKQNLGHFTSDTSSRMV | ||||||
Compositional bias | 357-372 | Polar residues | ||||
Sequence: KQNLGHFTSDTSSRMV |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 3 isoforms produced by Alternative splicing.
Q6PFE7-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length372
- Mass (Da)40,114
- Last updated2004-07-05 v1
- ChecksumBB3DA6710B78A530
Q6PFE7-2
- Name2
- Differences from canonical
- 146-146: G → GA
Q6PFE7-3
- Name3
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0A0MQL0 | A0A0A0MQL0_MOUSE | Tmeff1 | 346 | ||
A2AML9 | A2AML9_MOUSE | Tmeff1 | 151 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_024960 | 146 | in isoform 2 and isoform 3 | |||
Sequence: G → GA | ||||||
Sequence conflict | 235 | in Ref. 4; CAB90827 | ||||
Sequence: L → S | ||||||
Sequence conflict | 241 | in Ref. 4; CAB90827 | ||||
Sequence: D → P | ||||||
Sequence conflict | 244 | in Ref. 4; CAB90827 | ||||
Sequence: Q → L | ||||||
Alternative sequence | VSP_024961 | 251-252 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 357-372 | Polar residues | ||||
Sequence: KQNLGHFTSDTSSRMV | ||||||
Sequence conflict | 370 | in Ref. 4; CAB90827 | ||||
Sequence: R → K |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL772151 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL807771 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC057598 EMBL· GenBank· DDBJ | AAH57598.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ400622 EMBL· GenBank· DDBJ | CAB90827.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK043792 EMBL· GenBank· DDBJ | BAC31655.1 EMBL· GenBank· DDBJ | mRNA | ||
AK079633 EMBL· GenBank· DDBJ | BAC37709.1 EMBL· GenBank· DDBJ | mRNA |