Q6PFE7 · TEFF1_MOUSE

  • Protein
    Tomoregulin-1
  • Gene
    Tmeff1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry (PubMed:39048823).
Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (By similarity).
Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (By similarity).
Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (By similarity).

Features

Showing features for site.

137250100150200250300350
TypeIDPosition(s)Description
Site97-98Reactive bond
Site188-189Reactive bond

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Tomoregulin-1
  • Short names
    TR-1
  • Alternative names
    • M7365
    • Transmembrane protein with EGF-like and one follistatin-like domain

Gene names

    • Name
      Tmeff1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6PFE7
  • Secondary accessions
    • A2AJN3
    • Q8BRP7
    • Q8C536
    • Q9JJS1

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain37-322Extracellular
Transmembrane323-343Helical
Topological domain344-372Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Mice display increased susceptibility to herpes simplex virus 1 (HHV-1) infection in the brain but not in the periphery.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-36
ChainPRO_000028605737-372Tomoregulin-1
Glycosylation55N-linked (GlcNAc...) asparagine
Disulfide bond91↔121
Disulfide bond95↔114
Disulfide bond103↔135
Glycosylation139N-linked (GlcNAc...) asparagine
Disulfide bond182↔213
Disulfide bond186↔206
Disulfide bond195↔227
Disulfide bond267↔280
Disulfide bond275↔291
Disulfide bond293↔302

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Maily expressed in neurons (PubMed:39048823).
Expressed in brain, neurointermediate lobe, pars distalis, pancreas, ovary and testis (PubMed:11025219, PubMed:11165370).

Developmental stage

At 8.5 dpc, highly expressed in the first branchial arch, somites, splanchnic mesoderm and ventral foregut epithelium. At 9.5 dpc, highly expressed in motor neurons and superficial neurons from the neural tube, and in the dorsal part of diencephalon and mesencephalon. At 11.5 dpc and 12.5 dpc, expressed in limbs. At 15.5 dpc, highly expressed in brain and spinal cord.

Gene expression databases

Interaction

Subunit

May interact with ST14.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain90-137Kazal-like 1
Region139-161Disordered
Domain181-229Kazal-like 2
Domain263-303EGF-like
Region351-372Disordered
Compositional bias357-372Polar residues

Sequence similarities

Belongs to the tomoregulin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative splicing.

Q6PFE7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    372
  • Mass (Da)
    40,114
  • Last updated
    2004-07-05 v1
  • Checksum
    BB3DA6710B78A530
MGAQAPLRLPAAPPLAVCGYTSVLLLFAFCLPGSRASNQPAGGGGDCPGGRGKSNCSELNLRESDIRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKDITVVARGPCYSDNGSGSGEGEEEGSGAGAHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDVSLLGKKDDGLQYRPDVKDAGDEREDVYIGSHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSDTSSRMV

Q6PFE7-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q6PFE7-3

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0A0MQL0A0A0A0MQL0_MOUSETmeff1346
A2AML9A2AML9_MOUSETmeff1151

Sequence caution

The sequence CAB90827.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_024960146in isoform 2 and isoform 3
Sequence conflict235in Ref. 4; CAB90827
Sequence conflict241in Ref. 4; CAB90827
Sequence conflict244in Ref. 4; CAB90827
Alternative sequenceVSP_024961251-252in isoform 3
Compositional bias357-372Polar residues
Sequence conflict370in Ref. 4; CAB90827

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL772151
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL807771
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC057598
EMBL· GenBank· DDBJ
AAH57598.1
EMBL· GenBank· DDBJ
mRNA
AJ400622
EMBL· GenBank· DDBJ
CAB90827.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK043792
EMBL· GenBank· DDBJ
BAC31655.1
EMBL· GenBank· DDBJ
mRNA
AK079633
EMBL· GenBank· DDBJ
BAC37709.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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