Q6PER3 · MARE3_MOUSE

  • Protein
    Microtubule-associated protein RP/EB family member 3
  • Gene
    Mapre3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic microtubule
Cellular Componentmicrotubule cytoskeleton
Cellular Componentmicrotubule organizing center
Cellular Componentmicrotubule plus-end
Cellular Componentmidbody
Cellular Componentmitotic spindle astral microtubule end
Cellular Componentspindle midzone
Molecular Functionidentical protein binding
Molecular Functionmicrotubule binding
Molecular Functionmicrotubule plus-end binding
Molecular Functionprotein kinase binding
Biological Processcell division
Biological Processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Processpositive regulation of DNA-templated transcription
Biological Processprotein localization to microtubule
Biological Processregulation of microtubule polymerization
Biological Processregulation of microtubule polymerization or depolymerization
Biological Processspindle assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Microtubule-associated protein RP/EB family member 3
  • Alternative names
    • EB1 protein family member 3 (EBF3)
    • End-binding protein 3 (EB3)
    • RP3

Gene names

    • Name
      Mapre3

Organism names

  • Taxonomic identifier
  • Strain
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6PER3
  • Secondary accessions
    • Q61167

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002134291-281Microtubule-associated protein RP/EB family member 3
Modified residue162Phosphoserine
Modified residue176Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer (By similarity).
Heterodimer with MAPRE1 (By similarity).
Binds monomeric and polymerized GTP-bound tubulin. Interacts with DCTN1 and SRCIN1 (By similarity).
Binds to the C-terminal domain of APC (By similarity).
Interacts (via C-terminus) with CLIP1 (By similarity).
Interacts with SLAIN2 (By similarity).
Interacts with SLAIN1 (PubMed:21646404).
Interacts with APC2 (PubMed:17310996).
Interacts with AKAP9 (By similarity).
Interacts with PDE4DIP isoform 2/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain14-116Calponin-homology (CH)
Compositional bias157-177Polar residues
Region157-181Disordered
Domain194-264EB1 C-terminal
Region217-260APC-binding
Region217-281DCTN1-binding
Region260-281Disordered
Compositional bias262-281Acidic residues

Domain

Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.

Sequence similarities

Belongs to the MAPRE family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    281
  • Mass (Da)
    31,966
  • Last updated
    2004-07-05 v1
  • Checksum
    6713427C480838DC
MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQAKLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLARQGQDVAPPPNPGDQIFNKSKKLIGTAVPQRTSPTGPKNMQTSGRLSNVAPPCILRKNPPSARNGGHEADAQILELNQQLLDLKLTVDGLEKERDFYFSKLRDIELICQEHESENSPVISGIIGILYATEEGFAPPEDDEIEEHQQEDQDEY

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0J9YVB9A0A0J9YVB9_MOUSEMapre3140
D3Z6G3D3Z6G3_MOUSEMapre3266

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias157-177Polar residues
Compositional bias262-281Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC057918
EMBL· GenBank· DDBJ
AAH57918.1
EMBL· GenBank· DDBJ
mRNA
U51204
EMBL· GenBank· DDBJ
AAA96321.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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