Q6PCP5 · MFF_MOUSE
- ProteinMitochondrial fission factor
- GeneMff
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids291 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a role in mitochondrial and peroxisomal fission (PubMed:23283981, PubMed:30059978).
Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23283981).
May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity).
Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23283981).
May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial outer membrane | |
Cellular Component | mitochondrion | |
Cellular Component | peroxisome | |
Cellular Component | synaptic vesicle | |
Molecular Function | GTPase binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | protein-containing complex binding | |
Biological Process | mitochondrial fission | |
Biological Process | mitochondrion organization | |
Biological Process | positive regulation of cardiac muscle cell apoptotic process | |
Biological Process | positive regulation of mitochondrial fission | |
Biological Process | positive regulation of synaptic vesicle endocytosis | |
Biological Process | protein targeting to mitochondrion |
Names & Taxonomy
Protein names
- Recommended nameMitochondrial fission factor
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ6PCP5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion outer membrane ; Single-pass type IV membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-271 | Cytoplasmic | ||||
Sequence: MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQEFQDGVPNASVIMQVPERIVVTGNNEDISFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPLPTPQSEESRAVGRLKRERSMSENAVRQNGQLVRNDSIVTPSPPQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRPVLRGGSAAATSNPHHDNVRYGISNLDAAIEGASDDMTVVDAASLRRQIIKLNRRLQLLEEENKERAKREM | ||||||
Transmembrane | 272-289 | Helical; Anchor for type IV membrane protein | ||||
Sequence: VMYSITVAFWLLNSWLWF | ||||||
Topological domain | 290-291 | Mitochondrial intermembrane | ||||
Sequence: RR |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000289185 | 1-291 | Mitochondrial fission factor | |||
Sequence: MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQEFQDGVPNASVIMQVPERIVVTGNNEDISFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPLPTPQSEESRAVGRLKRERSMSENAVRQNGQLVRNDSIVTPSPPQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRPVLRGGSAAATSNPHHDNVRYGISNLDAAIEGASDDMTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR | ||||||
Modified residue | 89 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 129 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 131 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 146 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 146 | In isoform Q6PCP5-4; Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 149 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 151 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 178 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 182 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 244 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Homodimer (PubMed:30059978).
Interacts with DNM1L (PubMed:30059978).
Interacts with C11orf65/MFI; the interaction inhibits MFF interaction with DNM1L (PubMed:30059978).
Interacts with DNM1L (PubMed:30059978).
Interacts with C11orf65/MFI; the interaction inhibits MFF interaction with DNM1L (PubMed:30059978).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q6PCP5 | Dnm1l Q8K1M6 | 2 | EBI-21985996, EBI-2365792 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 106-134 | Disordered | ||||
Sequence: LERPLPTPQSEESRAVGRLKRERSMSENA | ||||||
Coiled coil | 240-271 | |||||
Sequence: VDAASLRRQIIKLNRRLQLLEEENKERAKREM |
Sequence similarities
Belongs to the Tango11 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q6PCP5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length291
- Mass (Da)32,931
- Last updated2004-07-05 v1
- Checksum658884A1EF8EBCFD
Q6PCP5-2
- Name2
Q6PCP5-3
- Name3
- Differences from canonical
- 148-200: Missing
Q6PCP5-4
- Name4
- Differences from canonical
- 147-220: IVTPSPPQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRPVLRGGSAAATSNPHHDNVR → M
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_025959 | 117 | in isoform 2 | |||
Sequence: E → EQ | ||||||
Alternative sequence | VSP_025960 | 147-220 | in isoform 4 | |||
Sequence: IVTPSPPQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRPVLRGGSAAATSNPHHDNVR → M | ||||||
Alternative sequence | VSP_025961 | 148-200 | in isoform 2 and isoform 3 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK017226 EMBL· GenBank· DDBJ | BAB30643.1 EMBL· GenBank· DDBJ | mRNA | ||
AK139649 EMBL· GenBank· DDBJ | BAE24093.1 EMBL· GenBank· DDBJ | mRNA | ||
BC016597 EMBL· GenBank· DDBJ | AAH16597.1 EMBL· GenBank· DDBJ | mRNA | ||
BC059229 EMBL· GenBank· DDBJ | AAH59229.1 EMBL· GenBank· DDBJ | mRNA |