Q6PCP5 · MFF_MOUSE

  • Protein
    Mitochondrial fission factor
  • Gene
    Mff
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plays a role in mitochondrial and peroxisomal fission (PubMed:23283981, PubMed:30059978).
Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23283981).
May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial outer membrane
Cellular Componentmitochondrion
Cellular Componentperoxisome
Cellular Componentsynaptic vesicle
Molecular FunctionGTPase binding
Molecular Functionprotein homodimerization activity
Molecular Functionprotein-containing complex binding
Biological Processmitochondrial fission
Biological Processmitochondrion organization
Biological Processpositive regulation of cardiac muscle cell apoptotic process
Biological Processpositive regulation of mitochondrial fission
Biological Processpositive regulation of synaptic vesicle endocytosis
Biological Processprotein targeting to mitochondrion

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial fission factor

Gene names

    • Name
      Mff

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6PCP5
  • Secondary accessions
    • Q3UT87
    • Q91VG0
    • Q9D3P5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-271Cytoplasmic
Transmembrane272-289Helical; Anchor for type IV membrane protein
Topological domain290-291Mitochondrial intermembrane

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002891851-291Mitochondrial fission factor
Modified residue89Phosphothreonine
Modified residue129Phosphoserine
Modified residue131Phosphoserine
Modified residue146Phosphoserine
Modified residue146In isoform Q6PCP5-4; Phosphoserine
Modified residue149Phosphothreonine
Modified residue151Phosphoserine
Modified residue178Phosphoserine
Modified residue182Phosphoserine
Modified residue244Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer (PubMed:30059978).
Interacts with DNM1L (PubMed:30059978).
Interacts with C11orf65/MFI; the interaction inhibits MFF interaction with DNM1L (PubMed:30059978).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q6PCP5Dnm1l Q8K1M62EBI-21985996, EBI-2365792

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, coiled coil.

TypeIDPosition(s)Description
Region106-134Disordered
Coiled coil240-271

Sequence similarities

Belongs to the Tango11 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q6PCP5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    291
  • Mass (Da)
    32,931
  • Last updated
    2004-07-05 v1
  • Checksum
    658884A1EF8EBCFD
MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQEFQDGVPNASVIMQVPERIVVTGNNEDISFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPLPTPQSEESRAVGRLKRERSMSENAVRQNGQLVRNDSIVTPSPPQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRPVLRGGSAAATSNPHHDNVRYGISNLDAAIEGASDDMTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR

Q6PCP5-2

Q6PCP5-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q6PCP5-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 147-220: IVTPSPPQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRPVLRGGSAAATSNPHHDNVR → M

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F7BC60F7BC60_MOUSEMff137
F6VAL0F6VAL0_MOUSEMff147
F7B1A4F7B1A4_MOUSEMff145
F7CTF8F7CTF8_MOUSEMff220
E0CYB9E0CYB9_MOUSEMff316
E0CYI3E0CYI3_MOUSEMff243

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_025959117in isoform 2
Alternative sequenceVSP_025960147-220in isoform 4
Alternative sequenceVSP_025961148-200in isoform 2 and isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK017226
EMBL· GenBank· DDBJ
BAB30643.1
EMBL· GenBank· DDBJ
mRNA
AK139649
EMBL· GenBank· DDBJ
BAE24093.1
EMBL· GenBank· DDBJ
mRNA
BC016597
EMBL· GenBank· DDBJ
AAH16597.1
EMBL· GenBank· DDBJ
mRNA
BC059229
EMBL· GenBank· DDBJ
AAH59229.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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