Q6PAY6 · HYPDH_XENLA
- ProteinHydroxyproline dehydrogenase
- Geneprodh2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids466 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using a quinone as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline.
Catalytic activity
- a quinone + trans-4-hydroxy-L-proline = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H+
Cofactor
Pathway
Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | oxidoreductase activity, acting on the CH-NH group of donors | |
Molecular Function | proline dehydrogenase activity | |
Biological Process | proline catabolic process to glutamate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHydroxyproline dehydrogenase
- EC number
- Short namesHYPDH
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionQ6PAY6
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000308626 | 1-466 | Hydroxyproline dehydrogenase | |||
Sequence: MRLLGRYLRLGSPRLCSRVWPTLPPSCSPHSTAAAAQAQGALSFSDGGVFKLKSSWEVARGLLIFRMCSFPSLVKHSEKMLSVSRRLLGRRLFEWGMKGSVYGQFVAGETLPEIRVCVDRLRQLGIHPMLAVPIEEDLGQAKSGERWYEQNESIMLDCVDLSAAGGDRPMMQLKITALMSAELCKLLSVHLSHPSNGPQLCPRSIVSIMEGKESAFSFLSEGENSHLRNSVRRLSRIAKHATANRVRVLVDAEYTYMNPALSLVTMAMMSQCNQSEPWIWNTYQCYLKDSFSLLSLDLDTARSLGLCFGVKLVRGAYMDKERKLSKQKGYADPIQHDWEATNRSYQRSLDKMLDLIGQNGQRHNLIVASHNEESVLHAVTRMAELGIDKGSGSVSFGQLLGMCDHVSLTLGQAGYLVYKSLPYGSVDSVLPYLIRRAQENQSVLQGIRKERDLLRRELKRRLFNQR |
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length466
- Mass (Da)52,329
- Last updated2004-07-05 v1
- Checksum873A4E7B7B336E99
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC059998 EMBL· GenBank· DDBJ | AAH59998.1 EMBL· GenBank· DDBJ | mRNA |